FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200880356> ?p ?o ?g. }

• W3200880356 abstract "Knee osteoarthritis (KOA) is a common and disabling condition characterized by attacks of pain around the joints, and it is a typical disease that develops chronic pain. Previous studies have proved that 5-HT 1 , 5-HT 2 , and 5-HT 3 receptors in the spinal cord are involved in electroacupuncture (EA) analgesia. The 5-HT 7 receptor plays antinociceptive role in the spinal cord. However, it is unclear whether the 5-HT 7 receptor is involved in EA analgesia. The 5-HT 7 receptor is a stimulatory G-protein (Gs)-coupled receptor that activates adenylyl cyclase (AC) to stimulate cyclic adenosine monophosphate (cAMP) formation, which in turn activates protein kinase A (PKA). In the present study, we found that EA significantly increased the tactile threshold and the expression of the 5-HT 7 receptor in the dorsal spinal cord. Intrathecal injection of 5-HT 7 receptor agonist AS-19 mimicked the analgesic effect of EA, while a selective 5-HT 7 receptor antagonist reversed this effect. Moreover, intrathecal injection of AC and PKA antagonists prior to EA intervention prevented its anti-allodynic effect. In addition, GABA A receptor antagonist bicuculline administered (intrathecal, i.t.) prior to EA intervention blocked the EA effect on pain hypersensitivity. Our data suggest that the spinal 5-HT 7 receptor activates GABAergic neurons through the Gs–cAMP–PKA pathway and participates in EA-mediated inhibition of chronic pain in a mouse model of KOA." @default.
• W3200880356 created "2021-09-27" @default.
• W3200880356 creator A5014170054 @default.
• W3200880356 creator A5019202893 @default.
• W3200880356 creator A5022953447 @default.
• W3200880356 creator A5027475930 @default.
• W3200880356 creator A5030180520 @default.
• W3200880356 creator A5037745816 @default.
• W3200880356 creator A5053591091 @default.
• W3200880356 creator A5057931640 @default.
• W3200880356 creator A5077338426 @default.
• W3200880356 creator A5080108966 @default.
• W3200880356 creator A5080177727 @default.
• W3200880356 creator A5080668108 @default.
• W3200880356 creator A5084607869 @default.
• W3200880356 date "2021-09-17" @default.
• W3200880356 modified "2023-10-16" @default.
• W3200880356 title "5-HT7 Receptor Is Involved in Electroacupuncture Inhibition of Chronic Pain in the Spinal Cord" @default.
• W3200880356 cites W1965148914 @default.
• W3200880356 cites W1972814213 @default.
• W3200880356 cites W1986606911 @default.
• W3200880356 cites W2001287468 @default.
• W3200880356 cites W2024457840 @default.
• W3200880356 cites W2029048970 @default.
• W3200880356 cites W2034102455 @default.
• W3200880356 cites W2039871355 @default.
• W3200880356 cites W2046219370 @default.
• W3200880356 cites W2059319888 @default.
• W3200880356 cites W2087454739 @default.
• W3200880356 cites W2092138689 @default.
• W3200880356 cites W2109172272 @default.
• W3200880356 cites W2115369213 @default.
• W3200880356 cites W2171926207 @default.
• W3200880356 cites W2172201406 @default.
• W3200880356 cites W237666551 @default.
• W3200880356 cites W2466991096 @default.
• W3200880356 cites W2549329103 @default.
• W3200880356 cites W2762571688 @default.
• W3200880356 cites W2795547095 @default.
• W3200880356 cites W2811137459 @default.
• W3200880356 cites W2899665894 @default.
• W3200880356 cites W2946883195 @default.
• W3200880356 cites W3011643067 @default.
• W3200880356 cites W3074717399 @default.
• W3200880356 doi "https://doi.org/10.3389/fnins.2021.733779" @default.
• W3200880356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8484641" @default.
• W3200880356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34602973" @default.
• W3200880356 hasPublicationYear "2021" @default.
• W3200880356 type Work @default.
• W3200880356 sameAs 3200880356 @default.
• W3200880356 citedByCount "2" @default.
• W3200880356 countsByYear W32008803562022 @default.
• W3200880356 countsByYear W32008803562023 @default.
• W3200880356 crossrefType "journal-article" @default.
• W3200880356 hasAuthorship W3200880356A5014170054 @default.
• W3200880356 hasAuthorship W3200880356A5019202893 @default.
• W3200880356 hasAuthorship W3200880356A5022953447 @default.
• W3200880356 hasAuthorship W3200880356A5027475930 @default.
• W3200880356 hasAuthorship W3200880356A5030180520 @default.
• W3200880356 hasAuthorship W3200880356A5037745816 @default.
• W3200880356 hasAuthorship W3200880356A5053591091 @default.
• W3200880356 hasAuthorship W3200880356A5057931640 @default.
• W3200880356 hasAuthorship W3200880356A5077338426 @default.
• W3200880356 hasAuthorship W3200880356A5080108966 @default.
• W3200880356 hasAuthorship W3200880356A5080177727 @default.
• W3200880356 hasAuthorship W3200880356A5080668108 @default.
• W3200880356 hasAuthorship W3200880356A5084607869 @default.
• W3200880356 hasBestOaLocation W32008803561 @default.
• W3200880356 hasConcept C118552586 @default.
• W3200880356 hasConcept C126322002 @default.
• W3200880356 hasConcept C134018914 @default.
• W3200880356 hasConcept C142724271 @default.
• W3200880356 hasConcept C15490471 @default.
• W3200880356 hasConcept C170493617 @default.
• W3200880356 hasConcept C204787440 @default.
• W3200880356 hasConcept C2776202274 @default.
• W3200880356 hasConcept C2776885963 @default.
• W3200880356 hasConcept C2778122271 @default.
• W3200880356 hasConcept C2778938600 @default.
• W3200880356 hasConcept C2779177108 @default.
• W3200880356 hasConcept C2779178603 @default.
• W3200880356 hasConcept C2780763569 @default.
• W3200880356 hasConcept C2780775167 @default.
• W3200880356 hasConcept C56837625 @default.
• W3200880356 hasConcept C71924100 @default.
• W3200880356 hasConcept C98274493 @default.
• W3200880356 hasConceptScore W3200880356C118552586 @default.
• W3200880356 hasConceptScore W3200880356C126322002 @default.
• W3200880356 hasConceptScore W3200880356C134018914 @default.
• W3200880356 hasConceptScore W3200880356C142724271 @default.
• W3200880356 hasConceptScore W3200880356C15490471 @default.
• W3200880356 hasConceptScore W3200880356C170493617 @default.
• W3200880356 hasConceptScore W3200880356C204787440 @default.
• W3200880356 hasConceptScore W3200880356C2776202274 @default.
• W3200880356 hasConceptScore W3200880356C2776885963 @default.
• W3200880356 hasConceptScore W3200880356C2778122271 @default.
• W3200880356 hasConceptScore W3200880356C2778938600 @default.
• W3200880356 hasConceptScore W3200880356C2779177108 @default.
• W3200880356 hasConceptScore W3200880356C2779178603 @default.
• W3200880356 hasConceptScore W3200880356C2780763569 @default.

• next