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- W3200896019 endingPage "10" @default.
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- W3200896019 abstract "Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques." @default.
- W3200896019 created "2021-09-27" @default.
- W3200896019 creator A5070161756 @default.
- W3200896019 creator A5071697774 @default.
- W3200896019 creator A5080583583 @default.
- W3200896019 creator A5088513008 @default.
- W3200896019 creator A5091127604 @default.
- W3200896019 creator A5091780036 @default.
- W3200896019 date "2021-09-12" @default.
- W3200896019 modified "2023-10-11" @default.
- W3200896019 title "Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation" @default.
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