Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200902507> ?p ?o ?g. }
- W3200902507 abstract "Background: structural maintenance of chromosomes protein 1A (SMC1A) is a crucial subunit of the cohesion protein complex and plays a vital role in cell cycle regulation, genomic stability maintenance, chromosome dynamics. Recent studies demonstrated that SMC1A participate in tumorigenesis. This reseach aims to explore the role and the underlying mechanisms of SMC1A in gastric cancer (GC). Methods: RT-qPCR and western blot were used to examine the expression levels of SMC1A in GC tissues and cell lines. The role of SMC1A on GC cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT)were analyzed. Furthermore,the mechanism of SMC1A action was investigated. Results: SMC1A was highly expressed in GC tissues and cell lines. The high expression of SMC1A indicated the poor overall survival of GC patients from Kaplan-Meier Plotter. Enhancing the expression of SMC1A in AGS remarkably promoted cell proliferation, migration and invasion. While knockdown of SMC1A in HCG27 inhibited cell proliferation, migration and invasion of HGC27 cells. Moreover, it is observed that SMC1A promoted EMT and malignant cell behaviors via regulating SNAI2. Conclusion: our study revealed SMC1A facilitates gastric cancer cell proliferation, migration and invasion via promoting SNAI2 activated EMT, which indicated SMC1A may be a potential target for gastric cancer therapy." @default.
- W3200902507 created "2021-09-27" @default.
- W3200902507 creator A5032229723 @default.
- W3200902507 creator A5036301012 @default.
- W3200902507 creator A5037641781 @default.
- W3200902507 creator A5045607397 @default.
- W3200902507 creator A5063127700 @default.
- W3200902507 creator A5069976108 @default.
- W3200902507 creator A5075246607 @default.
- W3200902507 creator A5086126151 @default.
- W3200902507 date "2021-09-24" @default.
- W3200902507 modified "2023-09-26" @default.
- W3200902507 title "SMC1A facilitates gastric cancer cells proliferation, migration and invasion via promoting SNAI2 activated EMT" @default.
- W3200902507 cites W1906566368 @default.
- W3200902507 cites W2012893008 @default.
- W3200902507 cites W2017908215 @default.
- W3200902507 cites W2070758971 @default.
- W3200902507 cites W2071388556 @default.
- W3200902507 cites W2078523916 @default.
- W3200902507 cites W2084009316 @default.
- W3200902507 cites W2095725724 @default.
- W3200902507 cites W2100300898 @default.
- W3200902507 cites W2103880276 @default.
- W3200902507 cites W2147723497 @default.
- W3200902507 cites W2158021558 @default.
- W3200902507 cites W2522144728 @default.
- W3200902507 cites W2524136267 @default.
- W3200902507 cites W2546694266 @default.
- W3200902507 cites W2755732042 @default.
- W3200902507 cites W2760739205 @default.
- W3200902507 cites W2808338995 @default.
- W3200902507 cites W2810376110 @default.
- W3200902507 cites W2890487969 @default.
- W3200902507 cites W2892751335 @default.
- W3200902507 cites W2926822414 @default.
- W3200902507 cites W2930373933 @default.
- W3200902507 cites W2953367224 @default.
- W3200902507 cites W2967371351 @default.
- W3200902507 cites W2976378994 @default.
- W3200902507 cites W2979436219 @default.
- W3200902507 cites W2981742231 @default.
- W3200902507 cites W3012057942 @default.
- W3200902507 cites W3088223358 @default.
- W3200902507 cites W3097037918 @default.
- W3200902507 cites W3097232642 @default.
- W3200902507 cites W3197857357 @default.
- W3200902507 doi "https://doi.org/10.1101/2021.09.23.461612" @default.
- W3200902507 hasPublicationYear "2021" @default.
- W3200902507 type Work @default.
- W3200902507 sameAs 3200902507 @default.
- W3200902507 citedByCount "0" @default.
- W3200902507 crossrefType "posted-content" @default.
- W3200902507 hasAuthorship W3200902507A5032229723 @default.
- W3200902507 hasAuthorship W3200902507A5036301012 @default.
- W3200902507 hasAuthorship W3200902507A5037641781 @default.
- W3200902507 hasAuthorship W3200902507A5045607397 @default.
- W3200902507 hasAuthorship W3200902507A5063127700 @default.
- W3200902507 hasAuthorship W3200902507A5069976108 @default.
- W3200902507 hasAuthorship W3200902507A5075246607 @default.
- W3200902507 hasAuthorship W3200902507A5086126151 @default.
- W3200902507 hasBestOaLocation W32009025071 @default.
- W3200902507 hasConcept C121608353 @default.
- W3200902507 hasConcept C137738243 @default.
- W3200902507 hasConcept C1491633281 @default.
- W3200902507 hasConcept C173396325 @default.
- W3200902507 hasConcept C29537977 @default.
- W3200902507 hasConcept C502942594 @default.
- W3200902507 hasConcept C54355233 @default.
- W3200902507 hasConcept C55493867 @default.
- W3200902507 hasConcept C555283112 @default.
- W3200902507 hasConcept C62112901 @default.
- W3200902507 hasConcept C81885089 @default.
- W3200902507 hasConcept C86803240 @default.
- W3200902507 hasConcept C95444343 @default.
- W3200902507 hasConceptScore W3200902507C121608353 @default.
- W3200902507 hasConceptScore W3200902507C137738243 @default.
- W3200902507 hasConceptScore W3200902507C1491633281 @default.
- W3200902507 hasConceptScore W3200902507C173396325 @default.
- W3200902507 hasConceptScore W3200902507C29537977 @default.
- W3200902507 hasConceptScore W3200902507C502942594 @default.
- W3200902507 hasConceptScore W3200902507C54355233 @default.
- W3200902507 hasConceptScore W3200902507C55493867 @default.
- W3200902507 hasConceptScore W3200902507C555283112 @default.
- W3200902507 hasConceptScore W3200902507C62112901 @default.
- W3200902507 hasConceptScore W3200902507C81885089 @default.
- W3200902507 hasConceptScore W3200902507C86803240 @default.
- W3200902507 hasConceptScore W3200902507C95444343 @default.
- W3200902507 hasLocation W32009025071 @default.
- W3200902507 hasOpenAccess W3200902507 @default.
- W3200902507 hasPrimaryLocation W32009025071 @default.
- W3200902507 hasRelatedWork W1956085363 @default.
- W3200902507 hasRelatedWork W2013549141 @default.
- W3200902507 hasRelatedWork W2531142332 @default.
- W3200902507 hasRelatedWork W2562103693 @default.
- W3200902507 hasRelatedWork W2808352915 @default.
- W3200902507 hasRelatedWork W2897479415 @default.
- W3200902507 hasRelatedWork W2903968497 @default.
- W3200902507 hasRelatedWork W2980649317 @default.
- W3200902507 hasRelatedWork W3022642502 @default.
- W3200902507 hasRelatedWork W3094951633 @default.