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• W3200907906 abstract "<ns3:p><ns3:bold>Background:</ns3:bold> Injecting drugs substantially increases the risk of hepatitis C virus (HCV) infection and is common in vulnerable population groups, such as the homeless and prisoners. Capturing accurate data on relative genotype distribution within these groups is essential to inform strategies to reduce HCV transmission. The aim of this study was to utilise a next-generation whole-genome sequencing method recently validated by Public Health England, in order to produce near complete HCV genomes.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> In total, 98 HCV positive patients were recruited from homeless hostels and drug treatment services through the National Health Services (NHS) Find and Treat (F&T) Service between May 2011 and June 2013 in London, UK. Samples were sequenced by Next-generation sequencing, with 88 complete HCV genomes constructed by a <ns3:italic>de novo</ns3:italic> assembly pipeline. They were analysed phylogenetically for an estimate of their genetic distance.</ns3:p><ns3:p> <ns3:bold>Results:</ns3:bold> Of the 88 complete HCV genomes, 50/88 (56.8%) were genotype 1; 32/88 (36.4%) genotype 3; 4/88 (4.5%) genotype 2; and 1/88 (1.1%) for genotypes 4 and 6 each. Subtype 1a had the highest number of samples (51.1%), followed by subtype 3a (35.2%), 1b (5.7%), and 2b (3.4%). Samples collected from drug treatment services had the highest number of genotype 1 (69%); genotypes 4 and 6 were only found from samples collected in homeless shelters. Small clusters of highly related genomic sequences were observed both across and within the vulnerable groups sampled.</ns3:p><ns3:p> <ns3:bold>Conclusions:</ns3:bold> Subsequent phylogenetic analysis provides a first indication that there are related HCV sequences amongst the three vulnerable population groups, reflecting their overlapping social behaviours. This study is the first presentation of whole genome HCV sequences from such vulnerable groups in London and paves the way for similar research in the future.</ns3:p>" @default.
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• W3200907906 date "2021-09-13" @default.
• W3200907906 modified "2023-09-26" @default.
• W3200907906 title "Assessing hepatitis C virus distribution among vulnerable populations in London using whole genome sequencing: results from the TB-REACH study" @default.
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• W3200907906 doi "https://doi.org/10.12688/wellcomeopenres.16907.1" @default.
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