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- W3200909332 abstract "A gene in a given taxonomic group is either present in every individual (core) or absent in at least a single individual (dispensable). Previous pangenomic studies have identified certain functional differences between core and dispensable genes. However, identifying if a gene belongs to the core or dispensable portion of the genome requires the construction of a pangenome, which involves sequencing the genomes of many individuals. Here we aim to leverage the previously characterized core and dispensable gene content for two grass species [Brachypodium distachyon (L.) P. Beauv. and Oryza sativa L.] to construct a machine learning model capable of accurately classifying genes as core or dispensable using only a single annotated reference genome. Such a model may mitigate the need for pangenome construction, an expensive hurdle especially in orphan crops, which often lack the adequate genomic resources." @default.
- W3200909332 created "2021-09-27" @default.
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- W3200909332 date "2021-09-17" @default.
- W3200909332 modified "2023-09-23" @default.
- W3200909332 title "Machine learning approaches to identify core and dispensable genes in pangenomes" @default.
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- W3200909332 doi "https://doi.org/10.1002/tpg2.20135" @default.
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