FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200948799> ?p ?o ?g. }

• W3200948799 endingPage "e0009742" @default.
• W3200948799 startingPage "e0009742" @default.
• W3200948799 abstract "The development of vaccines against one or all forms of human leishmaniasis remains hampered by a paucity of investment, at least in part resulting from the lack of well-evidenced and agreed estimates of vaccine demand. Starting from the definition of 4 main use cases (prevention of visceral leishmaniasis, prevention of cutaneous leishmaniasis, prevention of post-kala-azar dermal leishmaniasis and treatment of post-kala-azar dermal leishmaniasis), we have estimated the size of each target population, focusing on those endemic countries where incidence levels are sufficiently high to justify decisions to adopt a vaccine. We assumed a dual vaccine delivery strategy, including a wide age-range catch-up campaign before the start of routine immunisation. Vaccine characteristics and delivery parameters reflective of a target product profile and the likely duration of the clinical development effort were considered in forecasting the demand for each of the four indications. Over a period of 10 years, this demand is forecasted to range from 300–830 million doses for a vaccine preventing visceral leishmaniasis and 557–1400 million doses for a vaccine preventing cutaneous leishmaniasis under the different scenarios we simulated. In a scenario with an effective prophylactic visceral leishmaniasis vaccine, demand for use to prevent or treat post-kala-azar dermal leishmaniasis would be more limited (over the 10 years ~160,000 doses for prevention and ~7,000 doses for treatment). Demand would rise to exceed 330,000 doses, however, in the absence of an effective vaccine for visceral leishmaniasis. Because of the sizeable demand and potential for public health impact, a single-indication prophylactic vaccine for visceral or cutaneous leishmaniasis, and even more so a cross-protective prophylactic vaccine could attract the interest of commercial developers. Continuous refinement of these first-of-their kind estimates and confirmation of country willingness and ability to pay will be paramount to inform the decisions of policy makers and developers in relation to a leishmaniasis vaccine. Positive decisions can provide a much-needed contribution towards the achievement of global leishmaniasis control." @default.
• W3200948799 created "2021-09-27" @default.
• W3200948799 creator A5015534998 @default.
• W3200948799 creator A5041400856 @default.
• W3200948799 creator A5053400494 @default.
• W3200948799 creator A5053683132 @default.
• W3200948799 creator A5063928335 @default.
• W3200948799 date "2021-09-21" @default.
• W3200948799 modified "2023-10-11" @default.
• W3200948799 title "Human leishmaniasis vaccines: Use cases, target population and potential global demand" @default.
• W3200948799 cites W1967828232 @default.
• W3200948799 cites W2004411700 @default.
• W3200948799 cites W2056670179 @default.
• W3200948799 cites W2084889322 @default.
• W3200948799 cites W2114185071 @default.
• W3200948799 cites W2140465627 @default.
• W3200948799 cites W2161856351 @default.
• W3200948799 cites W2385321340 @default.
• W3200948799 cites W2427470371 @default.
• W3200948799 cites W2476602085 @default.
• W3200948799 cites W2604982796 @default.
• W3200948799 cites W2614458392 @default.
• W3200948799 cites W2744052425 @default.
• W3200948799 cites W2791826118 @default.
• W3200948799 cites W2806574476 @default.
• W3200948799 cites W2898594666 @default.
• W3200948799 cites W2901590062 @default.
• W3200948799 cites W2953111404 @default.
• W3200948799 cites W3040169100 @default.
• W3200948799 cites W3092849554 @default.
• W3200948799 cites W4244027559 @default.
• W3200948799 doi "https://doi.org/10.1371/journal.pntd.0009742" @default.
• W3200948799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8486101" @default.
• W3200948799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34547025" @default.
• W3200948799 hasPublicationYear "2021" @default.
• W3200948799 type Work @default.
• W3200948799 sameAs 3200948799 @default.
• W3200948799 citedByCount "19" @default.
• W3200948799 countsByYear W32009487992021 @default.
• W3200948799 countsByYear W32009487992022 @default.
• W3200948799 countsByYear W32009487992023 @default.
• W3200948799 crossrefType "journal-article" @default.
• W3200948799 hasAuthorship W3200948799A5015534998 @default.
• W3200948799 hasAuthorship W3200948799A5041400856 @default.
• W3200948799 hasAuthorship W3200948799A5053400494 @default.
• W3200948799 hasAuthorship W3200948799A5053683132 @default.
• W3200948799 hasAuthorship W3200948799A5063928335 @default.
• W3200948799 hasBestOaLocation W32009487991 @default.
• W3200948799 hasConcept C203014093 @default.
• W3200948799 hasConcept C2776555147 @default.
• W3200948799 hasConcept C2778689377 @default.
• W3200948799 hasConcept C2778702967 @default.
• W3200948799 hasConcept C2908647359 @default.
• W3200948799 hasConcept C71924100 @default.
• W3200948799 hasConcept C99454951 @default.
• W3200948799 hasConceptScore W3200948799C203014093 @default.
• W3200948799 hasConceptScore W3200948799C2776555147 @default.
• W3200948799 hasConceptScore W3200948799C2778689377 @default.
• W3200948799 hasConceptScore W3200948799C2778702967 @default.
• W3200948799 hasConceptScore W3200948799C2908647359 @default.
• W3200948799 hasConceptScore W3200948799C71924100 @default.
• W3200948799 hasConceptScore W3200948799C99454951 @default.
• W3200948799 hasFunder F4320306137 @default.
• W3200948799 hasFunder F4320307874 @default.
• W3200948799 hasFunder F4320310935 @default.
• W3200948799 hasIssue "9" @default.
• W3200948799 hasLocation W32009487991 @default.
• W3200948799 hasLocation W32009487992 @default.
• W3200948799 hasLocation W32009487993 @default.
• W3200948799 hasLocation W32009487994 @default.
• W3200948799 hasLocation W32009487995 @default.
• W3200948799 hasLocation W32009487996 @default.
• W3200948799 hasLocation W32009487997 @default.
• W3200948799 hasLocation W32009487998 @default.
• W3200948799 hasLocation W32009487999 @default.
• W3200948799 hasOpenAccess W3200948799 @default.
• W3200948799 hasPrimaryLocation W32009487991 @default.
• W3200948799 hasRelatedWork W1997570781 @default.
• W3200948799 hasRelatedWork W2052491883 @default.
• W3200948799 hasRelatedWork W2058411735 @default.
• W3200948799 hasRelatedWork W2080737986 @default.
• W3200948799 hasRelatedWork W2088894833 @default.
• W3200948799 hasRelatedWork W2103564871 @default.
• W3200948799 hasRelatedWork W2169455038 @default.
• W3200948799 hasRelatedWork W2256987796 @default.
• W3200948799 hasRelatedWork W3121352675 @default.
• W3200948799 hasRelatedWork W4205248250 @default.
• W3200948799 hasVolume "15" @default.
• W3200948799 isParatext "false" @default.
• W3200948799 isRetracted "false" @default.
• W3200948799 magId "3200948799" @default.
• W3200948799 workType "article" @default.