FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200969850> ?p ?o ?g. }

• W3200969850 abstract "MicroRNAs (miRNAs) are small noncoding RNAs ubiquitously expressed in the brain and regulate gene expression at the post-transcriptional level. The nuclear RNase III enzyme Drosha initiates the maturation process of miRNAs in the nucleus. Strong evidence suggests that dysregulation of miRNAs is involved in many neurological disorders including Alzheimer's disease (AD). Dysfunction of miRNA biogenesis components may be involved in the processes of those diseases. However, the role of Drosha in AD remains unknown. By using immunohistochemistry, biochemistry, and subcellular fractionation methods, we show here that the level of Drosha protein was significantly lower in the postmortem brain of human AD patients as well as in the transgenic rat model of AD. Interestingly, Drosha level was specifically reduced in neurons of the cortex and hippocampus but not in the cerebellum in the AD brain samples. In primary cortical neurons, amyloid-beta (Aβ) oligomers caused a p38 MAPK-dependent phosphorylation of Drosha, leading to its redistribution from the nucleus to the cytoplasm and a decrease in its level. This loss of Drosha function preceded Aβ-induced neuronal death. Importantly, inhibition of p38 MAPK activity or overexpression of Drosha protected neurons from Aβ oligomers-induced apoptosis. Taken together, these results establish a role for p38 MAPK-Drosha pathway in modulating neuronal viability under Aβ oligomers stress condition and implicate loss of Drosha as a key molecular change in the pathogenesis of AD." @default.
• W3200969850 created "2021-09-27" @default.
• W3200969850 creator A5005308572 @default.
• W3200969850 creator A5021129578 @default.
• W3200969850 creator A5026283704 @default.
• W3200969850 creator A5029563465 @default.
• W3200969850 creator A5033986806 @default.
• W3200969850 creator A5043094673 @default.
• W3200969850 creator A5061334968 @default.
• W3200969850 creator A5077385497 @default.
• W3200969850 creator A5087272196 @default.
• W3200969850 date "2021-09-16" @default.
• W3200969850 modified "2023-10-10" @default.
• W3200969850 title "p38 MAPK‐mediated loss of nuclear RNase III enzyme Drosha underlies amyloid beta‐induced neuronal stress in Alzheimer's disease" @default.
• W3200969850 cites W1500039090 @default.
• W3200969850 cites W1597198747 @default.
• W3200969850 cites W1964631913 @default.
• W3200969850 cites W1971402768 @default.
• W3200969850 cites W1974282614 @default.
• W3200969850 cites W1980269624 @default.
• W3200969850 cites W1980690754 @default.
• W3200969850 cites W1996915289 @default.
• W3200969850 cites W2002759338 @default.
• W3200969850 cites W2006247279 @default.
• W3200969850 cites W2008941741 @default.
• W3200969850 cites W2010461414 @default.
• W3200969850 cites W2014410632 @default.
• W3200969850 cites W2014764883 @default.
• W3200969850 cites W2015675204 @default.
• W3200969850 cites W2019028138 @default.
• W3200969850 cites W2021740591 @default.
• W3200969850 cites W2022749894 @default.
• W3200969850 cites W2042021963 @default.
• W3200969850 cites W2044194204 @default.
• W3200969850 cites W2045402423 @default.
• W3200969850 cites W2046847750 @default.
• W3200969850 cites W2051132333 @default.
• W3200969850 cites W2054109341 @default.
• W3200969850 cites W2055217118 @default.
• W3200969850 cites W2071925802 @default.
• W3200969850 cites W2072504660 @default.
• W3200969850 cites W2081858180 @default.
• W3200969850 cites W2082429191 @default.
• W3200969850 cites W2084973310 @default.
• W3200969850 cites W2090087301 @default.
• W3200969850 cites W2096410114 @default.
• W3200969850 cites W2099517697 @default.
• W3200969850 cites W2101480448 @default.
• W3200969850 cites W2103834862 @default.
• W3200969850 cites W2115115731 @default.
• W3200969850 cites W2119304779 @default.
• W3200969850 cites W2120522615 @default.
• W3200969850 cites W2128246500 @default.
• W3200969850 cites W2129812133 @default.
• W3200969850 cites W2146642335 @default.
• W3200969850 cites W2157926959 @default.
• W3200969850 cites W2160911021 @default.
• W3200969850 cites W2166578434 @default.
• W3200969850 cites W2243723775 @default.
• W3200969850 cites W2506844760 @default.
• W3200969850 cites W2510075458 @default.
• W3200969850 cites W2596618221 @default.
• W3200969850 cites W2618373227 @default.
• W3200969850 cites W2748162767 @default.
• W3200969850 cites W2805012765 @default.
• W3200969850 cites W2805261566 @default.
• W3200969850 cites W2883890257 @default.
• W3200969850 cites W2976163884 @default.
• W3200969850 cites W3200969850 @default.
• W3200969850 cites W4231182105 @default.
• W3200969850 cites W4232702505 @default.
• W3200969850 doi "https://doi.org/10.1111/acel.13434" @default.
• W3200969850 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8521488" @default.
• W3200969850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34528746" @default.
• W3200969850 hasPublicationYear "2021" @default.
• W3200969850 type Work @default.
• W3200969850 sameAs 3200969850 @default.
• W3200969850 citedByCount "10" @default.
• W3200969850 countsByYear W32009698502021 @default.
• W3200969850 countsByYear W32009698502022 @default.
• W3200969850 countsByYear W32009698502023 @default.
• W3200969850 crossrefType "journal-article" @default.
• W3200969850 hasAuthorship W3200969850A5005308572 @default.
• W3200969850 hasAuthorship W3200969850A5021129578 @default.
• W3200969850 hasAuthorship W3200969850A5026283704 @default.
• W3200969850 hasAuthorship W3200969850A5029563465 @default.
• W3200969850 hasAuthorship W3200969850A5033986806 @default.
• W3200969850 hasAuthorship W3200969850A5043094673 @default.
• W3200969850 hasAuthorship W3200969850A5061334968 @default.
• W3200969850 hasAuthorship W3200969850A5077385497 @default.
• W3200969850 hasAuthorship W3200969850A5087272196 @default.
• W3200969850 hasBestOaLocation W32009698501 @default.
• W3200969850 hasConcept C104317684 @default.
• W3200969850 hasConcept C126322002 @default.
• W3200969850 hasConcept C145059251 @default.
• W3200969850 hasConcept C166703698 @default.
• W3200969850 hasConcept C2776802755 @default.
• W3200969850 hasConcept C2776925932 @default.
• W3200969850 hasConcept C2779134260 @default.
• W3200969850 hasConcept C54355233 @default.

• next