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- W3200979658 abstract "Multiple myeloma is preceded by the early stages: monoclonal gammopathy of unknown significance (M.G.U.S.) and smoldering myeloma (S.M.M.), which are less genomically complex and where patients are overall healthier with preserved quality of life.This review focuses on the current evidence in risk stratification and initial therapy for these patients with the goal to delay progression to and/or cure multiple myeloma.Advances in the understanding of the factors that contribute to myeloma evolution coupled with new therapeutics that have high efficacy and limited toxicity have revolutionized our approach to early myeloma. Although our current recommendation continues to be to observe S.M.M. outside of clinical trials, the clinical benefit of lenalidomide sets the stage for combinations with immunotherapy, which, in our opinion, will likely lead to regulatory approvals and more widespread treatment of early myeloma." @default.
- W3200979658 created "2021-09-27" @default.
- W3200979658 creator A5017057018 @default.
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- W3200979658 date "2021-09-28" @default.
- W3200979658 modified "2023-09-27" @default.
- W3200979658 title "The benefits of early intervention using lenalidomide for high-risk smoldering multiple myeloma: emerging data and its promising clinical impact" @default.
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- W3200979658 doi "https://doi.org/10.1080/17474086.2021.1984225" @default.
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