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- W3200986945 abstract "Background: Collagen VI α6 chain (COL6A6) is one of the chains that makes up the triple helix of collagen VI. In our previous study, we found that family-specific COL6A6 gene polymorphisms are associated with early onset of atopic dermatitis (AD) in Koreans. Objectives: This study aimed to identify how COL6A6 changes in AD and its role.Methods: Histologic examination was performed in patients with AD, psoriasis, papular urticaria, and pityriasis rosea and controls. To determine the role of COL6A6, COL6A6 small interfering RNA (siRNA) was transfected into human keratinocytes and fibroblasts. RNA sequencing and real-time PCR were performed for mRNA expression analysis.Results: Total COL6A6 mRNA expression was higher in AD skin than in control skin. COL6A6 protein levels increased in the dermis of AD skin compared to controls, whereas a reduction in COL6A6 mRNA expression was observed in the basal layer of the epidermis. IL-4 and IL-13 induced COL6A6 protein expression in the dermis, while they suppressed COL6A6 mRNA expression in the epidermis. In the COL6A6 siRNA-transfected keratinocyte model, mRNA expressions of FLG, LORICRIN, and CASP14 decreased compared to controls. In contrast, in the COL6A6 siRNA-transfected fibroblast model, the mRNA expression of MMP1 increased.Conclusion: Our study suggests that COL6A6 induced by IL-4 and IL-13 may play a role in fibrotic remodeling and inflammatory processes, which are major features of AD." @default.
- W3200986945 created "2021-09-27" @default.
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- W3200986945 date "2020-01-01" @default.
- W3200986945 modified "2023-09-27" @default.
- W3200986945 title "FC 2-1 : The role of collagen VI α6 chain (COL6A6) gene in atopic dermatitis" @default.
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