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• W3201001513 startingPage "466" @default.
• W3201001513 abstract "RASSF4 (Ras-association domain family 4) is a protein-coding gene, regarded as a tumor suppressor regulated by DNA methylation. However, RASSF4 acts as a Janus in cell fate: death and survival. This review article focuses on the regulatory mechanisms of RASSF4 on cell death and cell survival and puts forward a comprehensive analysis of the relevant signaling pathways. The participation of RASSF4 in the regulation of intracellular store-operated Ca2+ entry also affects cell survival. Moreover, the mechanism of inducing abnormal expression of RASSF4 was summarized. We highlight recent advances in our knowledge of RASSF4 function in the development of cancer and other clinical diseases, which may provide insight into the controversial functions of RASSF4 and its potential application in disease therapy." @default.
• W3201001513 created "2021-09-27" @default.
• W3201001513 creator A5016247637 @default.
• W3201001513 creator A5019490879 @default.
• W3201001513 creator A5056101043 @default.
• W3201001513 creator A5061507643 @default.
• W3201001513 creator A5069389942 @default.
• W3201001513 creator A5070591545 @default.
• W3201001513 creator A5074959936 @default.
• W3201001513 creator A5089146037 @default.
• W3201001513 creator A5089833917 @default.
• W3201001513 date "2021-09-22" @default.
• W3201001513 modified "2023-10-17" @default.
• W3201001513 title "A “Janus” face of the RASSF4 signal in cell fate" @default.
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