Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201005105> ?p ?o ?g. }
- W3201005105 endingPage "3908" @default.
- W3201005105 startingPage "3894" @default.
- W3201005105 abstract "This research study utilized a light-sensitive drug, nifedipine (NFD), to understand the impact of processing parameters and formulation composition on drug degradation, crystallinity, and quality attributes (dimensions, hardness, disintegration time) of selective laser sintering (SLS)-based three-dimensional (3D)-printed dosage forms. Visible lasers with a wavelength around 455 nm are one of the laser sources used for selective laser sintering (SLS) processes, and some drugs such as nifedipine tend to absorb radiation at varying intensities around this wavelength. This phenomenon may lead to chemical degradation and solid-state transformation, which was assessed for nifedipine in formulations with varying amounts of vinyl pyrrolidone-vinyl acetate copolymer (Kollidon VA 64) and potassium aluminum silicate-based pearlescent pigment (Candurin) processed under different SLS conditions in the presented work. After preliminary screening, Candurin, surface temperature (ST), and laser speed (LS) were identified as the significant independent variables. Further, using the identified independent variables, a 17-run, randomized, Box-Behnken design was developed to understand the correlation trends and quantify the impact on degradation (%), crystallinity, and quality attributes (dimensions, hardness, disintegration time) employing qualitative and quantitative analytical tools. The design of experiments (DoEs) and statistical analysis observed that LS and Candurin (wt %) had a strong negative correlation on drug degradation, hardness, and weight, whereas ST had a strong positive correlation with drug degradation, amorphous conversion, and hardness of the 3D-printed dosage form. From this study, it can be concluded that formulation and processing parameters have a critical impact on stability and performance; hence, these parameters should be evaluated and optimized before exposing light-sensitive drugs to the SLS processes." @default.
- W3201005105 created "2021-09-27" @default.
- W3201005105 creator A5034469685 @default.
- W3201005105 creator A5039954649 @default.
- W3201005105 creator A5055542138 @default.
- W3201005105 creator A5060190112 @default.
- W3201005105 date "2021-09-16" @default.
- W3201005105 modified "2023-10-01" @default.
- W3201005105 title "Selective Laser Sintering of a Photosensitive Drug: Impact of Processing and Formulation Parameters on Degradation, Solid State, and Quality of 3D-Printed Dosage Forms" @default.
- W3201005105 cites W1022778776 @default.
- W3201005105 cites W139793748 @default.
- W3201005105 cites W1975942462 @default.
- W3201005105 cites W1978519495 @default.
- W3201005105 cites W1989977540 @default.
- W3201005105 cites W1995948625 @default.
- W3201005105 cites W2028799989 @default.
- W3201005105 cites W2032521777 @default.
- W3201005105 cites W2043301592 @default.
- W3201005105 cites W2045293316 @default.
- W3201005105 cites W2057174170 @default.
- W3201005105 cites W2071341693 @default.
- W3201005105 cites W2107845890 @default.
- W3201005105 cites W2113646170 @default.
- W3201005105 cites W2130522179 @default.
- W3201005105 cites W2253675932 @default.
- W3201005105 cites W2481799471 @default.
- W3201005105 cites W2516280312 @default.
- W3201005105 cites W2522517392 @default.
- W3201005105 cites W2558536136 @default.
- W3201005105 cites W2558537674 @default.
- W3201005105 cites W2586783706 @default.
- W3201005105 cites W2729529316 @default.
- W3201005105 cites W2791999130 @default.
- W3201005105 cites W2804221826 @default.
- W3201005105 cites W29033028 @default.
- W3201005105 cites W2911861386 @default.
- W3201005105 cites W2921530306 @default.
- W3201005105 cites W2928516672 @default.
- W3201005105 cites W2971365777 @default.
- W3201005105 cites W2983997499 @default.
- W3201005105 cites W2991537330 @default.
- W3201005105 cites W2996602442 @default.
- W3201005105 cites W2999987642 @default.
- W3201005105 cites W3003342647 @default.
- W3201005105 cites W3011316788 @default.
- W3201005105 cites W3023846942 @default.
- W3201005105 cites W3026428433 @default.
- W3201005105 cites W3039906429 @default.
- W3201005105 cites W3062521952 @default.
- W3201005105 cites W3091030234 @default.
- W3201005105 cites W3099039214 @default.
- W3201005105 cites W3135447973 @default.
- W3201005105 cites W3141939154 @default.
- W3201005105 cites W3184240302 @default.
- W3201005105 cites W3201692619 @default.
- W3201005105 doi "https://doi.org/10.1021/acs.molpharmaceut.1c00557" @default.
- W3201005105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34529431" @default.
- W3201005105 hasPublicationYear "2021" @default.
- W3201005105 type Work @default.
- W3201005105 sameAs 3201005105 @default.
- W3201005105 citedByCount "13" @default.
- W3201005105 countsByYear W32010051052022 @default.
- W3201005105 countsByYear W32010051052023 @default.
- W3201005105 crossrefType "journal-article" @default.
- W3201005105 hasAuthorship W3201005105A5034469685 @default.
- W3201005105 hasAuthorship W3201005105A5039954649 @default.
- W3201005105 hasAuthorship W3201005105A5055542138 @default.
- W3201005105 hasAuthorship W3201005105A5060190112 @default.
- W3201005105 hasBestOaLocation W32010051052 @default.
- W3201005105 hasConcept C127413603 @default.
- W3201005105 hasConcept C159985019 @default.
- W3201005105 hasConcept C178790620 @default.
- W3201005105 hasConcept C185592680 @default.
- W3201005105 hasConcept C192562407 @default.
- W3201005105 hasConcept C2777581544 @default.
- W3201005105 hasConcept C2779679103 @default.
- W3201005105 hasConcept C41008148 @default.
- W3201005105 hasConcept C42360764 @default.
- W3201005105 hasConcept C43617362 @default.
- W3201005105 hasConcept C46275449 @default.
- W3201005105 hasConcept C54237361 @default.
- W3201005105 hasConcept C56052488 @default.
- W3201005105 hasConcept C76155785 @default.
- W3201005105 hasConcept C77281830 @default.
- W3201005105 hasConceptScore W3201005105C127413603 @default.
- W3201005105 hasConceptScore W3201005105C159985019 @default.
- W3201005105 hasConceptScore W3201005105C178790620 @default.
- W3201005105 hasConceptScore W3201005105C185592680 @default.
- W3201005105 hasConceptScore W3201005105C192562407 @default.
- W3201005105 hasConceptScore W3201005105C2777581544 @default.
- W3201005105 hasConceptScore W3201005105C2779679103 @default.
- W3201005105 hasConceptScore W3201005105C41008148 @default.
- W3201005105 hasConceptScore W3201005105C42360764 @default.
- W3201005105 hasConceptScore W3201005105C43617362 @default.
- W3201005105 hasConceptScore W3201005105C46275449 @default.
- W3201005105 hasConceptScore W3201005105C54237361 @default.
- W3201005105 hasConceptScore W3201005105C56052488 @default.
- W3201005105 hasConceptScore W3201005105C76155785 @default.