Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201005809> ?p ?o ?g. }
- W3201005809 endingPage "e2124750" @default.
- W3201005809 startingPage "e2124750" @default.
- W3201005809 abstract "Although the incidence and prevalence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have been thought to have increased during the past decades, updated epidemiologic and survival data are lacking.To conduct an epidemiologic and survival analysis of the largest cohort of patients with GEP-NETs using the latest data and to establish a novel nomogram to predict the survival probability of individual patients with GEP-NETs.In this cohort study, 43 751 patients with GEP-NETs diagnosed from January 1, 1975, to December 31, 2015, were identified from the Surveillance, Epidemiology, and End Results Program. Associated data were used for epidemiologic and survival analysis, as well as the establishment and validation of a nomogram to predict the survival probability of individual patients with GEP-NETs. The study cutoff date was December 31, 2018. Statistical analysis was performed from February 1 to April 30, 2020.Incidence, factors associated with overall survival, and a nomogram model for patients with GEP-NETs.A total of 43 751 patients received a diagnosis of GEP-NETs from 1975 to 2015 (22 398 women [51.2%], 31 976 White patients [73.1%], 7097 Black patients [16.2%], 3207 Asian and Pacific Islander patients [7.3%], 270 American Indian and Alaska Native patients [0.6%], and 4546 patients of unknown race [10.4%]; mean [SD] age at diagnosis, 58 [15] years). The age-adjusted incidence rate of GEP-NETs increased 6.4-fold from 1975 to 2015 (annual percentage change [APC], 4.98; 95% CI, 4.75-5.20; P < .001). Furthermore, among site groups, the incidence of GEP-NETs in the rectum increased most significantly (APC, 6.43; 95% CI, 5.65-7.23; P < .001). As for stage and grade, the incidence increased the most in localized GEP-NETs (APC, 6.53; 95% CI, 6.08-6.97; P < .001) and G1 GEP-NETs (APC, 18.93; 95% CI, 17.44-20.43; P < .001). During the study period, the mean age at diagnosis for localized disease increased by 9.0 years (95% CI, 3.3-14.7 years; P = .002), which remained unchanged for regional and distant cases. On multivariable analyses, age, sex, marital status, and tumor size, grade, stage, and site were significantly associated with overall survival for patients with GEP-NETs (eg, patients with distant vs localized disease: hazard ratio, 10.32; 95% CI, 8.56-12.43; G4 vs G1 GEP-NET: hazard ratio, 6.37; 95% CI, 5.39-7.53). Furthermore, a nomogram comprising age, size, grade, stage, and site was established to predict the 3-year and 5-year survival probability, with the concordance indexes of 0.893 (95% CI, 0.883-0.903) for the internal validations and 0.880 (95% CI, 0.866-0.894) for the external validations. The receiver operating characteristic curve demonstrated that the nomogram exhibited better discrimination power than TNM classification (area under the curve for 3-year overall survival, 0.908 vs 0.795; for 5-year overall survival, 0.893 vs 0.791).In this study, the incidence and prevalence of GEP-NETs have continued to increase over 40 years, especially among patients with rectal GEP-NETs. In addition, this study suggests that a nomogram with 5 prognostic parameters may accurately quantify the risk of death among patients with GEP-NETs, indicating that it has satisfactory clinical practicality." @default.
- W3201005809 created "2021-09-27" @default.
- W3201005809 creator A5012278873 @default.
- W3201005809 creator A5032992180 @default.
- W3201005809 creator A5033704842 @default.
- W3201005809 creator A5040321635 @default.
- W3201005809 creator A5044630652 @default.
- W3201005809 creator A5050471258 @default.
- W3201005809 creator A5062476969 @default.
- W3201005809 date "2021-09-23" @default.
- W3201005809 modified "2023-10-16" @default.
- W3201005809 title "Epidemiologic Trends of and Factors Associated With Overall Survival for Patients With Gastroenteropancreatic Neuroendocrine Tumors in the United States" @default.
- W3201005809 cites W141793328 @default.
- W3201005809 cites W1575433014 @default.
- W3201005809 cites W1978257488 @default.
- W3201005809 cites W2062907835 @default.
- W3201005809 cites W2070283657 @default.
- W3201005809 cites W2071851324 @default.
- W3201005809 cites W2110922803 @default.
- W3201005809 cites W2116773250 @default.
- W3201005809 cites W2119958100 @default.
- W3201005809 cites W2138243027 @default.
- W3201005809 cites W2149214723 @default.
- W3201005809 cites W2165062498 @default.
- W3201005809 cites W2165162853 @default.
- W3201005809 cites W2172137144 @default.
- W3201005809 cites W2328989895 @default.
- W3201005809 cites W2608160487 @default.
- W3201005809 cites W2625031936 @default.
- W3201005809 cites W2759360753 @default.
- W3201005809 cites W2767948052 @default.
- W3201005809 cites W2784018303 @default.
- W3201005809 cites W2806388180 @default.
- W3201005809 cites W2908944154 @default.
- W3201005809 cites W2914383329 @default.
- W3201005809 cites W2956287179 @default.
- W3201005809 cites W2971407629 @default.
- W3201005809 cites W3015004022 @default.
- W3201005809 cites W3015314028 @default.
- W3201005809 cites W3032991919 @default.
- W3201005809 cites W3047231793 @default.
- W3201005809 cites W3049291508 @default.
- W3201005809 cites W3083575728 @default.
- W3201005809 cites W3093216105 @default.
- W3201005809 cites W3101451379 @default.
- W3201005809 cites W3107606740 @default.
- W3201005809 cites W3111217211 @default.
- W3201005809 cites W3119110836 @default.
- W3201005809 cites W4243550142 @default.
- W3201005809 cites W4247123733 @default.
- W3201005809 cites W4254483613 @default.
- W3201005809 doi "https://doi.org/10.1001/jamanetworkopen.2021.24750" @default.
- W3201005809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8461504" @default.
- W3201005809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34554237" @default.
- W3201005809 hasPublicationYear "2021" @default.
- W3201005809 type Work @default.
- W3201005809 sameAs 3201005809 @default.
- W3201005809 citedByCount "79" @default.
- W3201005809 countsByYear W32010058092021 @default.
- W3201005809 countsByYear W32010058092022 @default.
- W3201005809 countsByYear W32010058092023 @default.
- W3201005809 crossrefType "journal-article" @default.
- W3201005809 hasAuthorship W3201005809A5012278873 @default.
- W3201005809 hasAuthorship W3201005809A5032992180 @default.
- W3201005809 hasAuthorship W3201005809A5033704842 @default.
- W3201005809 hasAuthorship W3201005809A5040321635 @default.
- W3201005809 hasAuthorship W3201005809A5044630652 @default.
- W3201005809 hasAuthorship W3201005809A5050471258 @default.
- W3201005809 hasAuthorship W3201005809A5062476969 @default.
- W3201005809 hasBestOaLocation W32010058091 @default.
- W3201005809 hasConcept C10515644 @default.
- W3201005809 hasConcept C107130276 @default.
- W3201005809 hasConcept C120665830 @default.
- W3201005809 hasConcept C121332964 @default.
- W3201005809 hasConcept C126322002 @default.
- W3201005809 hasConcept C143998085 @default.
- W3201005809 hasConcept C144024400 @default.
- W3201005809 hasConcept C149923435 @default.
- W3201005809 hasConcept C34626388 @default.
- W3201005809 hasConcept C61511704 @default.
- W3201005809 hasConcept C71924100 @default.
- W3201005809 hasConcept C72563966 @default.
- W3201005809 hasConceptScore W3201005809C10515644 @default.
- W3201005809 hasConceptScore W3201005809C107130276 @default.
- W3201005809 hasConceptScore W3201005809C120665830 @default.
- W3201005809 hasConceptScore W3201005809C121332964 @default.
- W3201005809 hasConceptScore W3201005809C126322002 @default.
- W3201005809 hasConceptScore W3201005809C143998085 @default.
- W3201005809 hasConceptScore W3201005809C144024400 @default.
- W3201005809 hasConceptScore W3201005809C149923435 @default.
- W3201005809 hasConceptScore W3201005809C34626388 @default.
- W3201005809 hasConceptScore W3201005809C61511704 @default.
- W3201005809 hasConceptScore W3201005809C71924100 @default.
- W3201005809 hasConceptScore W3201005809C72563966 @default.
- W3201005809 hasIssue "9" @default.
- W3201005809 hasLocation W32010058091 @default.
- W3201005809 hasLocation W32010058092 @default.
- W3201005809 hasLocation W32010058093 @default.