FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201009436> ?p ?o ?g. }

• W3201009436 endingPage "1291" @default.
• W3201009436 startingPage "1284" @default.
• W3201009436 abstract "Rosmarinic acid (RA) dose-dependently ameliorates acetaminophen (APAP) induced hepatotoxicity in rats. However, whether RA hepatoprotective effect is by regulating RACK1 and its downstream signals is still unclear.This study explores the RA protective effect on APAP-induced ALI and its mechanism.Sixty Kunming mice 6-8 weeks old were randomly separated into six groups (n = 10) and pre-treated with normal saline, ammonium glycyrrhetate (AG) or RA (10, 20 or 40 mg/kg i.p./day) for two consecutive weeks. Then, APAP (300 mg/kg, i.g.) was administrated to induce ALI, except for the control. Serum alanine/aspartate aminotransferases (ALT and AST), malondialdehyde (MDA), superoxide dismutase (SOD) and histopathology were used to authenticate RA effect. The liver RACK1 and TNF-α were measured by western blot.Compared with the APAP group, different dosages RA significantly decreased ALT (52.09 ± 7.98, 55.13 ± 10.19, 65.08 ± 27.61 U/L, p < 0.05), AST (114.78 ± 19.87, 115.29 ± 31.91, 101.78 ± 21.85 U/L, p < 0.05), MDA (2.37 ± 0.87, 2.13 ± 0.87, 1.86 ± 0.39 nmol/mg, p < 0.01) and increased SOD (306.178 ± 90.80, 459.21 ± 58.54, 444.01 ± 78.09 U/mg, p < 0.05). With increasing doses of RA, RACK1 and TNF-α expression decreased. Moreover, the RACK1 and TNF-α levels were positively correlated with MDA (r = 0.8453 and r = 0.9391, p < 0.01).Our findings support RA as a hepatoprotective agent to improve APAP-induced ALI and the antioxidant effect mediated through RACK1/TNF-α pathway." @default.
• W3201009436 created "2021-09-27" @default.
• W3201009436 creator A5001630552 @default.
• W3201009436 creator A5026876134 @default.
• W3201009436 creator A5048581828 @default.
• W3201009436 creator A5053475939 @default.
• W3201009436 creator A5053727718 @default.
• W3201009436 creator A5066480040 @default.
• W3201009436 creator A5075959791 @default.
• W3201009436 date "2021-01-01" @default.
• W3201009436 modified "2023-10-03" @default.
• W3201009436 title "Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect" @default.
• W3201009436 cites W1018162543 @default.
• W3201009436 cites W1859746580 @default.
• W3201009436 cites W1968386898 @default.
• W3201009436 cites W1985304052 @default.
• W3201009436 cites W1986463549 @default.
• W3201009436 cites W1991222100 @default.
• W3201009436 cites W2036768705 @default.
• W3201009436 cites W2045404952 @default.
• W3201009436 cites W2055313154 @default.
• W3201009436 cites W2057752710 @default.
• W3201009436 cites W2059655597 @default.
• W3201009436 cites W2062010039 @default.
• W3201009436 cites W2091530696 @default.
• W3201009436 cites W2094273616 @default.
• W3201009436 cites W2098082055 @default.
• W3201009436 cites W2116189372 @default.
• W3201009436 cites W2124149023 @default.
• W3201009436 cites W2129244805 @default.
• W3201009436 cites W2160775206 @default.
• W3201009436 cites W2397081843 @default.
• W3201009436 cites W2410469242 @default.
• W3201009436 cites W2526759468 @default.
• W3201009436 cites W2547338826 @default.
• W3201009436 cites W2587531375 @default.
• W3201009436 cites W2592039648 @default.
• W3201009436 cites W2606912529 @default.
• W3201009436 cites W2607210007 @default.
• W3201009436 cites W2616998606 @default.
• W3201009436 cites W2617388507 @default.
• W3201009436 cites W2724825600 @default.
• W3201009436 cites W2737518257 @default.
• W3201009436 cites W2744791138 @default.
• W3201009436 cites W2790026612 @default.
• W3201009436 cites W2791498498 @default.
• W3201009436 cites W2801928995 @default.
• W3201009436 cites W2811289303 @default.
• W3201009436 cites W2884611526 @default.
• W3201009436 cites W2913407408 @default.
• W3201009436 cites W2964368704 @default.
• W3201009436 cites W3018080144 @default.
• W3201009436 doi "https://doi.org/10.1080/13880209.2021.1974059" @default.
• W3201009436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8451635" @default.
• W3201009436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34517734" @default.
• W3201009436 hasPublicationYear "2021" @default.
• W3201009436 type Work @default.
• W3201009436 sameAs 3201009436 @default.
• W3201009436 citedByCount "12" @default.
• W3201009436 countsByYear W32010094362021 @default.
• W3201009436 countsByYear W32010094362022 @default.
• W3201009436 countsByYear W32010094362023 @default.
• W3201009436 crossrefType "journal-article" @default.
• W3201009436 hasAuthorship W3201009436A5001630552 @default.
• W3201009436 hasAuthorship W3201009436A5026876134 @default.
• W3201009436 hasAuthorship W3201009436A5048581828 @default.
• W3201009436 hasAuthorship W3201009436A5053475939 @default.
• W3201009436 hasAuthorship W3201009436A5053727718 @default.
• W3201009436 hasAuthorship W3201009436A5066480040 @default.
• W3201009436 hasAuthorship W3201009436A5075959791 @default.
• W3201009436 hasBestOaLocation W32010094361 @default.
• W3201009436 hasConcept C126322002 @default.
• W3201009436 hasConcept C162156334 @default.
• W3201009436 hasConcept C181199279 @default.
• W3201009436 hasConcept C185592680 @default.
• W3201009436 hasConcept C2775838275 @default.
• W3201009436 hasConcept C2776151105 @default.
• W3201009436 hasConcept C2776637226 @default.
• W3201009436 hasConcept C2777397205 @default.
• W3201009436 hasConcept C2778004101 @default.
• W3201009436 hasConcept C2778401633 @default.
• W3201009436 hasConcept C2778722691 @default.
• W3201009436 hasConcept C2778771215 @default.
• W3201009436 hasConcept C2780829032 @default.
• W3201009436 hasConcept C538909803 @default.
• W3201009436 hasConcept C55493867 @default.
• W3201009436 hasConcept C71924100 @default.
• W3201009436 hasConcept C98274493 @default.
• W3201009436 hasConceptScore W3201009436C126322002 @default.
• W3201009436 hasConceptScore W3201009436C162156334 @default.
• W3201009436 hasConceptScore W3201009436C181199279 @default.
• W3201009436 hasConceptScore W3201009436C185592680 @default.
• W3201009436 hasConceptScore W3201009436C2775838275 @default.
• W3201009436 hasConceptScore W3201009436C2776151105 @default.
• W3201009436 hasConceptScore W3201009436C2776637226 @default.
• W3201009436 hasConceptScore W3201009436C2777397205 @default.
• W3201009436 hasConceptScore W3201009436C2778004101 @default.
• W3201009436 hasConceptScore W3201009436C2778401633 @default.

• next