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- W3201016288 abstract "Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon). Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon)." @default.
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- W3201016288 date "2021-09-01" @default.
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- W3201016288 title "A novel redox cycle diverts cells from oncogene-induced senescence into cancer" @default.
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- W3201016288 doi "https://doi.org/10.1016/j.molcel.2021.08.023" @default.
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