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- W3201019094 abstract "Conventional methods of soaking contact lenses (CLs) using drug-packaging solutions to load hydrophobic drugs, such as travoprost (TP), result in low drug loading and high burst release, along with changes in the critical properties of the lens. In this study, as a substitute for eye drop therapy, travoprost-loaded PEGylated solid lipid nanoparticles (TP-pSLNs) were used to improve the drug loading capacity of contact lenses (TP-pSLN-CLs), while also sustaining ocular drug delivery to prolong the anti-glaucoma effect. The pSLNs were spherical in shape with an average hydrodynamic diameter of 221–257 nm and a zeta potential ranging from −27.3 to −20.4 mV. The pSLNs led to improved swelling, optical transmittance, and protein adherence of the CLs compared to the non-PEGylated SLN congeners (TP-SLNs-CL) and conventional soaked lens (SM-TP-CL). The SM-TP-CL lens showed low travoprost uptake, high burst release, and a short release duration of up to 48 h. The TP-SLN-CL and TP-pSLN-CL lenses showed high drug uptake and sustained release for up to 144 h and 120 h, respectively. Although PEGylation increased the drug loading capacity, the release rate was high in the initial hours. Based on histopathological analysis, TP-pSLN-CLs were found to be safe and did not induce ocular irritation. In the rabbit tear fluid model, the TP-pSLN-20%CL batch showed high drug concentration at all time points up to 120 h compared to the SM-TP-CL (48 h) and eye drop solution (2 h). In conclusion, by using the soaking method, pSLNs improved the travoprost loading/uptake in the contact lens and improved the in vitro and in vivo results for better clinical outcomes in glaucoma treatment." @default.
- W3201019094 created "2021-09-27" @default.
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- W3201019094 date "2021-12-01" @default.
- W3201019094 modified "2023-10-12" @default.
- W3201019094 title "RETRACTED: Travoprost-loaded PEGylated solid lipid nanoparticle-laden silicone contact lens for managing glaucoma" @default.
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- W3201019094 doi "https://doi.org/10.1016/j.jddst.2021.102731" @default.
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