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- W3201033013 abstract "In this thesis, the coherent signal response of ascanning reflectance confocal microscope (SRCM) was investigated.With the primary application of this technology in skin imaging, aformulation for how tissue-like objects affect the signalgeneration, and thus image formation, was developed. A repeatable,stable turbid phantom for characterization of SRCMs was designedand built. Numerical simulations were developed to model thecoherent interference of focal light and background light; lightfrom the nominal focus in the tissue and the light that ismultiply scattered, respectively. This latter contribution, thebackground light, degrades contrast and lowers the reliability ofthe images. A metric to understand this reliability and fidelityof the images taken with an SRCM when imaging in turbid media ispresented with associated theoretical and experimental results.The coherent model was found to be in good agreement with realdata. This model was used to investigate two additionalillumination modes: TEM10 and a novel implementation ofdifferential-interference-contrast (DIC) which I callnonreversible DIC (NR-DIC). It was theoretically andexperimentally verified that these modes can improve the degree offidelity associated with SRCM images when using these illuminationand/or detection schemes. The fidelity, which I define as thewidth of the signal distribution from a nominally uniform object,was found to be improved up to 3X; the associated reduction incoherent background is shown to reach over 100X. The NR-DIC modein particular is also shown to exhibit linear-birefringencesensitivity with a split-pinhole detector." @default.
- W3201033013 created "2021-09-27" @default.
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- W3201033013 date "2011-01-01" @default.
- W3201033013 modified "2023-09-27" @default.
- W3201033013 title "Pupil engineered confocal microscopy for investigation ofturbid media" @default.
- W3201033013 hasPublicationYear "2011" @default.
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