Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201044728> ?p ?o ?g. }
- W3201044728 endingPage "1881" @default.
- W3201044728 startingPage "1866" @default.
- W3201044728 abstract "The brain is a complex organ composed of billions of neurons connected through excitatory and inhibitory synapses. Its structure reveals a modular topological organization, where neurons are arranged in interconnected assemblies. The generated patterns of electrophysiological activity are shaped by two main factors: network heterogeneity and the topological properties of the underlying connectivity that strongly push the dynamics toward different brain-states. In this work, we exploited an innovative polymeric structure coupled to Micro-Electrode Arrays (MEAs) to recreate in vitro heterogeneous interconnected (modular) neuronal networks made up of cortical and hippocampal neurons. We investigated the propagation of spike sequences between the two interconnected subpopulations during the networks' development, correlating functional and structural connectivity to dynamics. The simultaneous presence of two neuronal types shaped the features of the functional connections (excitation vs. inhibition), orchestrating the emerging patterns of electrophysiological activity. In particular, we found that hippocampal neurons mostly project inhibitory connections toward the cortical counterpart modulating the temporal scale of the population events (network bursts). In contrast, cortical neurons establish a larger amount of intrapopulation connections. Moreover, we proved topological properties such as small-worldness, degree distribution, and modularity of neuronal assemblies were favored by the physical environment where networks developed and matured." @default.
- W3201044728 created "2021-09-27" @default.
- W3201044728 creator A5010752863 @default.
- W3201044728 creator A5020342643 @default.
- W3201044728 creator A5024860745 @default.
- W3201044728 creator A5031544477 @default.
- W3201044728 creator A5042893408 @default.
- W3201044728 date "2021-09-17" @default.
- W3201044728 modified "2023-10-01" @default.
- W3201044728 title "Functional Inhibitory Connections Modulate the Electrophysiological Activity Patterns of Cortical-Hippocampal Ensembles" @default.
- W3201044728 cites W1529448825 @default.
- W3201044728 cites W1705218924 @default.
- W3201044728 cites W1967538785 @default.
- W3201044728 cites W1971375081 @default.
- W3201044728 cites W1977019056 @default.
- W3201044728 cites W1983493842 @default.
- W3201044728 cites W1994801733 @default.
- W3201044728 cites W1996577210 @default.
- W3201044728 cites W1996603253 @default.
- W3201044728 cites W1999287295 @default.
- W3201044728 cites W1999653836 @default.
- W3201044728 cites W2005317473 @default.
- W3201044728 cites W2010677111 @default.
- W3201044728 cites W2016789142 @default.
- W3201044728 cites W2021489208 @default.
- W3201044728 cites W2023924009 @default.
- W3201044728 cites W2027781650 @default.
- W3201044728 cites W2032773159 @default.
- W3201044728 cites W2034579441 @default.
- W3201044728 cites W2036596825 @default.
- W3201044728 cites W2039182173 @default.
- W3201044728 cites W2044312508 @default.
- W3201044728 cites W2044730840 @default.
- W3201044728 cites W2046964936 @default.
- W3201044728 cites W2049598659 @default.
- W3201044728 cites W2062619493 @default.
- W3201044728 cites W2063062105 @default.
- W3201044728 cites W2063251739 @default.
- W3201044728 cites W2064241002 @default.
- W3201044728 cites W2066693695 @default.
- W3201044728 cites W2071904606 @default.
- W3201044728 cites W2074019524 @default.
- W3201044728 cites W2076167286 @default.
- W3201044728 cites W2079600992 @default.
- W3201044728 cites W2079790369 @default.
- W3201044728 cites W2081697226 @default.
- W3201044728 cites W2086523769 @default.
- W3201044728 cites W2090441615 @default.
- W3201044728 cites W2095025631 @default.
- W3201044728 cites W2105475977 @default.
- W3201044728 cites W2106700142 @default.
- W3201044728 cites W2126578880 @default.
- W3201044728 cites W2135952327 @default.
- W3201044728 cites W2144813759 @default.
- W3201044728 cites W2151936673 @default.
- W3201044728 cites W2158948112 @default.
- W3201044728 cites W2161771297 @default.
- W3201044728 cites W2162016003 @default.
- W3201044728 cites W2167095271 @default.
- W3201044728 cites W2167279371 @default.
- W3201044728 cites W2175528441 @default.
- W3201044728 cites W2240145697 @default.
- W3201044728 cites W2286760230 @default.
- W3201044728 cites W2409304057 @default.
- W3201044728 cites W2479151136 @default.
- W3201044728 cites W2538734062 @default.
- W3201044728 cites W2567598763 @default.
- W3201044728 cites W2782442390 @default.
- W3201044728 cites W2898097990 @default.
- W3201044728 cites W2902921620 @default.
- W3201044728 cites W2942322349 @default.
- W3201044728 cites W2980290789 @default.
- W3201044728 cites W2982858594 @default.
- W3201044728 cites W3092403194 @default.
- W3201044728 cites W3110269954 @default.
- W3201044728 cites W3185670581 @default.
- W3201044728 cites W4242456969 @default.
- W3201044728 cites W4249587697 @default.
- W3201044728 doi "https://doi.org/10.1093/cercor/bhab318" @default.
- W3201044728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34535794" @default.
- W3201044728 hasPublicationYear "2021" @default.
- W3201044728 type Work @default.
- W3201044728 sameAs 3201044728 @default.
- W3201044728 citedByCount "15" @default.
- W3201044728 countsByYear W32010447282022 @default.
- W3201044728 countsByYear W32010447282023 @default.
- W3201044728 crossrefType "journal-article" @default.
- W3201044728 hasAuthorship W3201044728A5010752863 @default.
- W3201044728 hasAuthorship W3201044728A5020342643 @default.
- W3201044728 hasAuthorship W3201044728A5024860745 @default.
- W3201044728 hasAuthorship W3201044728A5031544477 @default.
- W3201044728 hasAuthorship W3201044728A5042893408 @default.
- W3201044728 hasConcept C112592302 @default.
- W3201044728 hasConcept C144024400 @default.
- W3201044728 hasConcept C148762608 @default.
- W3201044728 hasConcept C149923435 @default.
- W3201044728 hasConcept C169760540 @default.
- W3201044728 hasConcept C17077164 @default.