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• W3201046058 abstract "Recent studies suggest that brain cell type specific intracellular environments may play important roles in the generation of structurally different protein aggregates that define neurodegenerative diseases. Using human induced pluripotent stem cells (hiPSC) and biochemical and vibrational spectroscopy techniques, we studied whether Parkinson's disease (PD) patient genomes could modulate alpha-synuclein (aSYN) protein aggregates formation. We found increased β-sheets and aggregated aSYN in PD patient hiPSC-derived midbrain cells, compared to controls. Importantly, we discovered that aSYN protein aggregation is modulated by patient brain cells' intracellular milieus at the primary nucleation phase. Additionally, we found changes in the formation of aSYN fibrils when employing cellular extracts from familial PD compared to idiopathic PD, in a Thioflavin T-based fluorescence assay. The data suggest that changes in cellular milieu induced by patient genomes trigger structural changes of aSYN potentially leading to the formation of strains having different structures, properties and seeding propensities." @default.
• W3201046058 created "2021-09-27" @default.
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• W3201046058 date "2021-09-16" @default.
• W3201046058 modified "2023-10-15" @default.
• W3201046058 title "The intracellular milieu of Parkinson’s disease patient brain cells modulates alpha-synuclein protein aggregation" @default.
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• W3201046058 doi "https://doi.org/10.1186/s40478-021-01256-w" @default.
• W3201046058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8444604" @default.
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• W3201046058 hasPublicationYear "2021" @default.
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