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- W3201048327 abstract "Keratinocytes are rich in lipids and are the main sensitive cells to ultraviolet (UV) rays. Theaflavins are the core functional components of black tea and are known as the soft gold in tea. In this study, ultraviolet-B (UVB) irradiation caused apoptosis and necrosis of human epidermal keratinocytes (HaCaT). EGCG and the four theaflavins had anti-UVB damage activity, among which theaflavin-3'-gallate (TF3'G) had the best activity. The results of biophysical and molecular biology experiments showed that TF3'G has anti-damage effects on UVB-irradiated HaCaT cells through the dual effects of photoprotection and maintenance of cell homeostasis. That is, TF3'G preincubation could absorb UV rays, reduce the accumulation of aging-related heterochromatin (SAHF) formation, increase mitochondrial membrane potential, downregulate NF-κB inflammation pathways, inhibit the formation of cytotoxic aggregates, and protect biological macromolecules Structure, etc. The accumulation of conjugated π bonds and the balance benzoquinone are the core functional structure of TF3'G with high efficiency and low toxicity. The study indicates that TF3'G has the potential to inhibit the photoaging and intrinsic aging of skin cells." @default.
- W3201048327 created "2021-09-27" @default.
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- W3201048327 date "2021-11-01" @default.
- W3201048327 modified "2023-10-16" @default.
- W3201048327 title "Anti-damage effect of theaflavin-3′-gallate from black tea on UVB-irradiated HaCaT cells by photoprotection and maintaining cell homeostasis" @default.
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- W3201048327 doi "https://doi.org/10.1016/j.jphotobiol.2021.112304" @default.
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