Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201058864> ?p ?o ?g. }
- W3201058864 endingPage "100352" @default.
- W3201058864 startingPage "100352" @default.
- W3201058864 abstract "Glucocorticoids (GCs) regulate a myriad of physiological systems, such as the immune and nervous systems. Systemic GC levels in blood are often measured as an indicator of local GC levels in target organs. However, several extra-adrenal organs can produce and metabolize GCs locally. More sensitive and specific methods for GC analysis (i.e., mass spectrometry) allow measurement of local GC levels in small tissue samples with low GC concentrations. Consequently, is it now apparent that systemic GC levels often do not reflect local GC levels. Here, we review the use of systemic GC measurements in clinical and research settings, discuss instances where systemic GC levels do not reflect local GC levels, and present evidence that local GC levels provide useful insights, with a focus on local GC production in the thymus (immunosteroids) and brain (neurosteroids). Lastly, we suggest key areas for further research, such as the roles of immunosteroids and neurosteroids in neonatal programming and the potential clinical relevance of local GC modulators." @default.
- W3201058864 created "2021-09-27" @default.
- W3201058864 creator A5042729677 @default.
- W3201058864 creator A5079633771 @default.
- W3201058864 date "2021-12-01" @default.
- W3201058864 modified "2023-10-14" @default.
- W3201058864 title "Glucocorticoid production in the thymus and brain: Immunosteroids and neurosteroids" @default.
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