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• W3201067384 abstract "Maternal exposure to stressors during lactation has previously been demonstrated to impact various aspects of milk synthesis and to have long-term physiological effects on offspring. Much of the current literature investigating the effects of stress during lactation has used acute stressors, and the studies investigating the effects of chronic stressors largely focus on neurological changes. Further, temporal variation in glucocorticoids across lactation in response to stressors has rarely been assessed. The present work uses a novel male intruder paradigm to model the effects of chronic stress on maternal fecal corticosterone metabolites (FCMs) in Sprague-Dawley rats across lactation. FCM levels were elevated in chronically-stressed mothers relative to the control group. Further, FCMs in the stress group were time-dependent either due to repeated exposure to the stressor or lactation stage. Together, this work demonstrates the efficacy of this established paradigm in increasing circulating glucocorticoids in lactating rats. These results highlight the need for repeated temporal sampling, as glucocorticoid levels in response to a chronic stressor may change across lactation." @default.
• W3201067384 created "2021-09-27" @default.
• W3201067384 creator A5008417799 @default.
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• W3201067384 date "2021-12-01" @default.
• W3201067384 modified "2023-10-13" @default.
• W3201067384 title "Changes in maternal fecal corticosterone metabolites across lactation and in response to chronic stress" @default.
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• W3201067384 doi "https://doi.org/10.1016/j.ygcen.2021.113916" @default.
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