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• W3201067863 abstract "Since the outset of the coronavirus disease 2019 (COVID-19) pandemic, the gut microbiome in COVID-19 has garnered substantial interest, given its significant roles in human health and pathophysiology. Accumulating evidence is unveiling that the gut microbiome is broadly altered in COVID-19, including the bacterial microbiome, mycobiome, and virome. Overall, the gut microbial ecological network is significantly weakened and becomes sparse in patients with COVID-19, together with a decrease in gut microbiome diversity. Beyond the existence of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the gut microbiome of patients with COVID-19 is also characterized by enrichment of opportunistic bacteria, fungi, and eukaryotic viruses, which are also associated with disease severity and presentation. Meanwhile, a multitude of symbiotic bacteria and bacteriophages are decreased in abundance in patients with COVID-19. Such gut microbiome features persist in a significant subset of patients with COVID-19 even after disease resolution, coinciding with 'long COVID' (also known as post-acute sequelae of COVID-19). The broadly-altered gut microbiome is largely a consequence of SARS-CoV-2infection and its downstream detrimental effects on the systemic host immunity and the gut milieu. The impaired host immunity and distorted gut microbial ecology, particularly loss of low-abundance beneficial bacteria and blooms of opportunistic fungi including Candida, may hinder the reassembly of the gut microbiome post COVID-19. Future investigation is necessary to fully understand the role of the gut microbiome in host immunity against SARS-CoV-2 infection, as well as the long-term effect of COVID-19 on the gut microbiome in relation to the host health after the pandemic." @default.
• W3201067863 created "2021-09-27" @default.
• W3201067863 creator A5006550483 @default.
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• W3201067863 creator A5076381576 @default.
• W3201067863 date "2021-10-01" @default.
• W3201067863 modified "2023-10-17" @default.
• W3201067863 title "Gut Microbiome Alterations in COVID-19" @default.
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• W3201067863 doi "https://doi.org/10.1016/j.gpb.2021.09.004" @default.
• W3201067863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8478109" @default.
• W3201067863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34560321" @default.
• W3201067863 hasPublicationYear "2021" @default.
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