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• W3201099110 endingPage "550" @default.
• W3201099110 startingPage "531" @default.
• W3201099110 abstract "As costs of next-generation sequencing decrease, identification of genetic variants has far outpaced our ability to understand their functional consequences. This lack of understanding is a central challenge to a key promise of pharmacogenomics: using genetic information to guide drug selection and dosing. Recently developed multiplexed assays of variant effect enable experimental measurement of the function of thousands of variants simultaneously. Here, we describe multiplexed assays that have been performed on nearly 25,000 variants in eight key pharmacogenes (ADRB2, CYP2C9, CYP2C19, NUDT15, SLCO1B1, TMPT, VKORC1, and the LDLR promoter), discuss advances in experimental design, and explore key challenges that must be overcome to maximize the utility of multiplexed functional data." @default.
• W3201099110 created "2021-09-27" @default.
• W3201099110 creator A5000189657 @default.
• W3201099110 creator A5001281377 @default.
• W3201099110 creator A5038039561 @default.
• W3201099110 creator A5039189570 @default.
• W3201099110 creator A5069458369 @default.
• W3201099110 date "2022-01-06" @default.
• W3201099110 modified "2023-10-01" @default.
• W3201099110 title "Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays" @default.
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