FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201121421> ?p ?o ?g. }

• W3201121421 abstract "Background Oridonin (Ori), the main bioactive ingredient of the natural anti-inflammatory herb Rabdosia rubescens , could be a covalent inhibitor of the NLRP3 inflammasome. Solid organ transplantation provides a life-saving optional therapy for patients with end-stage organ dysfunction. The long-term survival of solid organ transplantation remains restricted because of the possibility of rejection and the toxicity, infection, cardiovascular disease, and malignancy related to immunosuppressive (IS) drugs. However, the pathogenic mechanisms involved remain unclear. The ideal IS drugs to prevent allograft rejection have not been identified. Here, we investigated whether Ori could prolong the in vivo survival of completely mismatched cardiac allografts. Methods The cardiac transplantation models were conducted among three groups of mice from C57BL/6NCrSlc (B6/N) or C3H/HeNSlc (C3H) to C3H: the syngeneic and the allogeneic group, whose recipients were treated with vehicle of Ori, and the Ori treatment group, in which the recipients were transplanted hearts from MHC-I mismatched donors and treated with different dosages of Ori from post-operative day (POD) 0 to 7. Then, we investigated the effect of Ori on bone marrow-derived dendritic cell (BMDC) and allogeneic mixed lymphocyte reaction in vitro . Results Ori with 3, 10, and 15 mg/kg Ori could prolong the survival (MST = 22.8, 49.2, and 65.3 days, respectively). We found that infiltrating CD8 + T cells and macrophages were decreased, and regulatory T cells (Tregs) were expanded in allografts on POD7. The mRNA level of IL-1β and IFN-γ of allografts was downregulated. Mechanistically, Ori-treated BMDCs suppressed T-cell proliferation and IFN-γ + CD4 + T-cell differentiation, along with the expansion of Tregs and IL-10 + CD4 + T cells. Ori inhibited NOD, LRR-, and pyrin domain-containing protein 3 (NLRP3) expression; attenuated NF-κB and IκBα phosphorylation in LPS-activated BMDCs; downregulated NLRP3, Caspase-1, IL-1β, IL-18, and IFN-γ; and upregulated IL-10 expression. Conclusions Our findings highlight the potential of Ori as a novel and natural IS agent to improve transplant tolerance. Ori could exert IS activity through decreasing IL-1β and IL-18 production and Th1 differentiation and proliferation and expanding Tregs via inhibiting the NF-κB/NLRP3 signaling pathway." @default.
• W3201121421 created "2021-09-27" @default.
• W3201121421 creator A5012929232 @default.
• W3201121421 creator A5018117726 @default.
• W3201121421 creator A5021275847 @default.
• W3201121421 creator A5024695372 @default.
• W3201121421 creator A5028799114 @default.
• W3201121421 creator A5045647861 @default.
• W3201121421 creator A5085203241 @default.
• W3201121421 date "2021-09-10" @default.
• W3201121421 modified "2023-10-16" @default.
• W3201121421 title "Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NF-κB/NLRP3 Pathway" @default.
• W3201121421 cites W1529674879 @default.
• W3201121421 cites W1559677484 @default.
• W3201121421 cites W1636793459 @default.
• W3201121421 cites W1915064147 @default.
• W3201121421 cites W1971915082 @default.
• W3201121421 cites W1972670677 @default.
• W3201121421 cites W1986674043 @default.
• W3201121421 cites W2005385070 @default.
• W3201121421 cites W2007370671 @default.
• W3201121421 cites W2011998180 @default.
• W3201121421 cites W2019495623 @default.
• W3201121421 cites W2044757050 @default.
• W3201121421 cites W2049885762 @default.
• W3201121421 cites W2050449334 @default.
• W3201121421 cites W2056210235 @default.
• W3201121421 cites W2067846827 @default.
• W3201121421 cites W2071973557 @default.
• W3201121421 cites W2092843904 @default.
• W3201121421 cites W2094237560 @default.
• W3201121421 cites W2129388928 @default.
• W3201121421 cites W2132474463 @default.
• W3201121421 cites W2141722144 @default.
• W3201121421 cites W2301091825 @default.
• W3201121421 cites W2420118023 @default.
• W3201121421 cites W2515890030 @default.
• W3201121421 cites W2516663634 @default.
• W3201121421 cites W2535232750 @default.
• W3201121421 cites W2580424951 @default.
• W3201121421 cites W2590652781 @default.
• W3201121421 cites W2735993381 @default.
• W3201121421 cites W2763335049 @default.
• W3201121421 cites W2768412315 @default.
• W3201121421 cites W2776988169 @default.
• W3201121421 cites W2778840601 @default.
• W3201121421 cites W2800992180 @default.
• W3201121421 cites W2810072585 @default.
• W3201121421 cites W2810188540 @default.
• W3201121421 cites W2883296062 @default.
• W3201121421 cites W2884445384 @default.
• W3201121421 cites W2943293743 @default.
• W3201121421 cites W2952963248 @default.
• W3201121421 cites W3037150536 @default.
• W3201121421 cites W3087139986 @default.
• W3201121421 cites W3131528222 @default.
• W3201121421 doi "https://doi.org/10.3389/fimmu.2021.719574" @default.
• W3201121421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8462485" @default.
• W3201121421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34566976" @default.
• W3201121421 hasPublicationYear "2021" @default.
• W3201121421 type Work @default.
• W3201121421 sameAs 3201121421 @default.
• W3201121421 citedByCount "10" @default.
• W3201121421 countsByYear W32011214212022 @default.
• W3201121421 countsByYear W32011214212023 @default.
• W3201121421 crossrefType "journal-article" @default.
• W3201121421 hasAuthorship W3201121421A5012929232 @default.
• W3201121421 hasAuthorship W3201121421A5018117726 @default.
• W3201121421 hasAuthorship W3201121421A5021275847 @default.
• W3201121421 hasAuthorship W3201121421A5024695372 @default.
• W3201121421 hasAuthorship W3201121421A5028799114 @default.
• W3201121421 hasAuthorship W3201121421A5045647861 @default.
• W3201121421 hasAuthorship W3201121421A5085203241 @default.
• W3201121421 hasBestOaLocation W32011214211 @default.
• W3201121421 hasConcept C126322002 @default.
• W3201121421 hasConcept C150903083 @default.
• W3201121421 hasConcept C167672396 @default.
• W3201121421 hasConcept C203014093 @default.
• W3201121421 hasConcept C207001950 @default.
• W3201121421 hasConcept C2776090121 @default.
• W3201121421 hasConcept C2776914184 @default.
• W3201121421 hasConcept C2777209026 @default.
• W3201121421 hasConcept C2778740727 @default.
• W3201121421 hasConcept C2911091166 @default.
• W3201121421 hasConcept C71924100 @default.
• W3201121421 hasConcept C86803240 @default.
• W3201121421 hasConcept C8891405 @default.
• W3201121421 hasConcept C98274493 @default.
• W3201121421 hasConceptScore W3201121421C126322002 @default.
• W3201121421 hasConceptScore W3201121421C150903083 @default.
• W3201121421 hasConceptScore W3201121421C167672396 @default.
• W3201121421 hasConceptScore W3201121421C203014093 @default.
• W3201121421 hasConceptScore W3201121421C207001950 @default.
• W3201121421 hasConceptScore W3201121421C2776090121 @default.
• W3201121421 hasConceptScore W3201121421C2776914184 @default.
• W3201121421 hasConceptScore W3201121421C2777209026 @default.
• W3201121421 hasConceptScore W3201121421C2778740727 @default.
• W3201121421 hasConceptScore W3201121421C2911091166 @default.
• W3201121421 hasConceptScore W3201121421C71924100 @default.
• W3201121421 hasConceptScore W3201121421C86803240 @default.

• next