FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201161721> ?p ?o ?g. }

• W3201161721 endingPage "3246" @default.
• W3201161721 startingPage "3236" @default.
• W3201161721 abstract "Abstract Background Solid‐phase platelet crossmatch (PXM) testing is used to help manage patients with platelet transfusion‐refractoriness. Recently, we published the first report of false‐negative PXM results from prozone effect that was mitigated using sample dilution. This study aimed to describe the prevalence of PXM prozone effect and the levels of class I HLA antibodies (HLA‐Abs) associated with positive PXM results and with false‐negative PXM results from prozone effect. Study Design and Methods A cross‐sectional study of patients undergoing PXM testing from July 2019 through December 2020 was performed. All PXM tests were run simultaneously using undiluted and 1:4 diluted patient plasma. Prozone effect was defined as a negative PXM result using undiluted patient plasma but a positive PXM result using 1:4 diluted patient plasma. Results Among 59 patients, 830 individual ABO‐compatible PXM results yielded an overall positivity rate of 25.8% (214/830) and a false‐negative rate from prozone effect of 4.7% (10/214). Among the 28 patients with class I HLA‐Ab testing and no other anti‐platelet antibodies, maximum HLA‐Ab mean fluorescence intensity (MFI) was significantly associated with a positive PXM result ( p < .0001; AUC approx. 0.9) and categorized into negative (<3700), indeterminate (3700–10300), and positive (>10300) maximum HLA‐Ab MFI zones. Maximum HLA‐Ab MFI, however, was not associated with prozone effect ( p = .17; AUC approx. 0.6). Discussion While there is a strong predictive association between class I HLA‐Ab levels and positive PXM results, PXM prozone effect is a common occurrence not associated with class I HLA‐Ab levels, so additional testing with diluted samples should be considered." @default.
• W3201161721 created "2021-09-27" @default.
• W3201161721 creator A5000317450 @default.
• W3201161721 creator A5031055751 @default.
• W3201161721 creator A5037203052 @default.
• W3201161721 creator A5038627799 @default.
• W3201161721 creator A5067123786 @default.
• W3201161721 creator A5028462591 @default.
• W3201161721 date "2021-09-15" @default.
• W3201161721 modified "2023-10-12" @default.
• W3201161721 title "Prozone rates in the <scp>solid‐phase</scp> platelet crossmatch assay and correlation with class I <scp>HLA</scp> antibody levels" @default.
• W3201161721 cites W1893506387 @default.
• W3201161721 cites W1904477962 @default.
• W3201161721 cites W1964549099 @default.
• W3201161721 cites W1983549042 @default.
• W3201161721 cites W2002818147 @default.
• W3201161721 cites W2006617902 @default.
• W3201161721 cites W2006759664 @default.
• W3201161721 cites W2034170740 @default.
• W3201161721 cites W2037378026 @default.
• W3201161721 cites W2037585278 @default.
• W3201161721 cites W2069434924 @default.
• W3201161721 cites W2094346882 @default.
• W3201161721 cites W2107584112 @default.
• W3201161721 cites W2112032535 @default.
• W3201161721 cites W2147093981 @default.
• W3201161721 cites W2150444704 @default.
• W3201161721 cites W2153942592 @default.
• W3201161721 cites W2407038155 @default.
• W3201161721 cites W2507617653 @default.
• W3201161721 cites W2587083577 @default.
• W3201161721 cites W2614283672 @default.
• W3201161721 cites W2757618960 @default.
• W3201161721 cites W2906578057 @default.
• W3201161721 cites W2943899162 @default.
• W3201161721 cites W2979725017 @default.
• W3201161721 cites W2981853772 @default.
• W3201161721 cites W3000683795 @default.
• W3201161721 cites W3002724357 @default.
• W3201161721 cites W3006279049 @default.
• W3201161721 cites W3092560522 @default.
• W3201161721 cites W4256635201 @default.
• W3201161721 doi "https://doi.org/10.1111/trf.16660" @default.
• W3201161721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34523730" @default.
• W3201161721 hasPublicationYear "2021" @default.
• W3201161721 type Work @default.
• W3201161721 sameAs 3201161721 @default.
• W3201161721 citedByCount "2" @default.
• W3201161721 countsByYear W32011617212023 @default.
• W3201161721 crossrefType "journal-article" @default.
• W3201161721 hasAuthorship W3201161721A5000317450 @default.
• W3201161721 hasAuthorship W3201161721A5028462591 @default.
• W3201161721 hasAuthorship W3201161721A5031055751 @default.
• W3201161721 hasAuthorship W3201161721A5037203052 @default.
• W3201161721 hasAuthorship W3201161721A5038627799 @default.
• W3201161721 hasAuthorship W3201161721A5067123786 @default.
• W3201161721 hasConcept C126322002 @default.
• W3201161721 hasConcept C147483822 @default.
• W3201161721 hasConcept C159654299 @default.
• W3201161721 hasConcept C188280979 @default.
• W3201161721 hasConcept C203014093 @default.
• W3201161721 hasConcept C71924100 @default.
• W3201161721 hasConcept C89560881 @default.
• W3201161721 hasConcept C90924648 @default.
• W3201161721 hasConceptScore W3201161721C126322002 @default.
• W3201161721 hasConceptScore W3201161721C147483822 @default.
• W3201161721 hasConceptScore W3201161721C159654299 @default.
• W3201161721 hasConceptScore W3201161721C188280979 @default.
• W3201161721 hasConceptScore W3201161721C203014093 @default.
• W3201161721 hasConceptScore W3201161721C71924100 @default.
• W3201161721 hasConceptScore W3201161721C89560881 @default.
• W3201161721 hasConceptScore W3201161721C90924648 @default.
• W3201161721 hasIssue "11" @default.
• W3201161721 hasLocation W32011617211 @default.
• W3201161721 hasLocation W32011617212 @default.
• W3201161721 hasOpenAccess W3201161721 @default.
• W3201161721 hasPrimaryLocation W32011617211 @default.
• W3201161721 hasRelatedWork W13788639 @default.
• W3201161721 hasRelatedWork W1982913438 @default.
• W3201161721 hasRelatedWork W1998274488 @default.
• W3201161721 hasRelatedWork W2045443994 @default.
• W3201161721 hasRelatedWork W2060315896 @default.
• W3201161721 hasRelatedWork W2082094685 @default.
• W3201161721 hasRelatedWork W2083197627 @default.
• W3201161721 hasRelatedWork W2418625451 @default.
• W3201161721 hasRelatedWork W3198306613 @default.
• W3201161721 hasRelatedWork W4242457046 @default.
• W3201161721 hasVolume "61" @default.
• W3201161721 isParatext "false" @default.
• W3201161721 isRetracted "false" @default.
• W3201161721 magId "3201161721" @default.
• W3201161721 workType "article" @default.