Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201173663> ?p ?o ?g. }
- W3201173663 endingPage "1114" @default.
- W3201173663 startingPage "1099" @default.
- W3201173663 abstract "Multiple myeloma (MM) remains an incurable disease with a median overall survival of approximately 5 years. Gain or amplification of 1q21 (1q21+) occurs in around 40% of patients with MM and generally portends a poor prognosis. Patients with MM who harbor 1q21+ are at increased risk of drug resistance, disease progression, and death. New pharmacotherapies with novel modes of action are required to overcome the negative prognostic impact of 1q21+. Areas covered: This review discusses the detection, biology, prognosis, and therapeutic targeting of 1q21+ in newly diagnosed and relapsed MM. Patients with MM and 1q21+ tend to present with higher tumor burden, greater end-organ damage, and more co-occurring high-risk cytogenetic abnormalities than patients without 1q21+. The chromosomal rearrangements associated with 1q21+ result in dysregulation of genes involved in oncogenesis. Identification and characterization of the 1q21+ molecular targets are needed to inform on prognosis and treatment strategy. Clinical trial data are emerging that addition of isatuximab to combination therapies may improve outcomes in patients with 1q21+ MM. Expert opinion: In the next 5 years, the results of ongoing research and trials are likely to focus on the therapeutic impact and treatment decisions associated with 1q21+ in MM." @default.
- W3201173663 created "2021-09-27" @default.
- W3201173663 creator A5005850190 @default.
- W3201173663 creator A5010627919 @default.
- W3201173663 creator A5011827756 @default.
- W3201173663 creator A5015802614 @default.
- W3201173663 creator A5026574827 @default.
- W3201173663 creator A5030524608 @default.
- W3201173663 creator A5030703994 @default.
- W3201173663 creator A5049970120 @default.
- W3201173663 creator A5080347550 @default.
- W3201173663 creator A5082118917 @default.
- W3201173663 creator A5085426613 @default.
- W3201173663 date "2021-10-08" @default.
- W3201173663 modified "2023-10-18" @default.
- W3201173663 title "Chromosomal 1q21 abnormalities in multiple myeloma: a review of translational, clinical research, and therapeutic strategies" @default.
- W3201173663 cites W1494138467 @default.
- W3201173663 cites W1514044817 @default.
- W3201173663 cites W1747881616 @default.
- W3201173663 cites W1902692042 @default.
- W3201173663 cites W1912299294 @default.
- W3201173663 cites W1971287695 @default.
- W3201173663 cites W1976133851 @default.
- W3201173663 cites W1976766209 @default.
- W3201173663 cites W1981866022 @default.
- W3201173663 cites W1987144611 @default.
- W3201173663 cites W1993745533 @default.
- W3201173663 cites W1995784947 @default.
- W3201173663 cites W2000189234 @default.
- W3201173663 cites W2003352819 @default.
- W3201173663 cites W2004543856 @default.
- W3201173663 cites W2007480898 @default.
- W3201173663 cites W2028946248 @default.
- W3201173663 cites W2041992457 @default.
- W3201173663 cites W2045010580 @default.
- W3201173663 cites W2046408556 @default.
- W3201173663 cites W2048217074 @default.
- W3201173663 cites W2051169179 @default.
- W3201173663 cites W2052586881 @default.
- W3201173663 cites W2055391669 @default.
- W3201173663 cites W2060187655 @default.
- W3201173663 cites W2061735512 @default.
- W3201173663 cites W2062516102 @default.
- W3201173663 cites W2069827448 @default.
- W3201173663 cites W2070408634 @default.
- W3201173663 cites W2072259475 @default.
- W3201173663 cites W2075032656 @default.
- W3201173663 cites W2084499660 @default.
- W3201173663 cites W2085937148 @default.
- W3201173663 cites W2086862058 @default.
- W3201173663 cites W2089902119 @default.
- W3201173663 cites W2094013301 @default.
- W3201173663 cites W2105507863 @default.
- W3201173663 cites W2108646201 @default.
- W3201173663 cites W2110648338 @default.
- W3201173663 cites W2112538093 @default.
- W3201173663 cites W2115385885 @default.
- W3201173663 cites W2121998150 @default.
- W3201173663 cites W2128192762 @default.
- W3201173663 cites W2128644254 @default.
- W3201173663 cites W2131837746 @default.
- W3201173663 cites W2132544749 @default.
- W3201173663 cites W2132838873 @default.
- W3201173663 cites W2141550675 @default.
- W3201173663 cites W2146659622 @default.
- W3201173663 cites W2150101334 @default.
- W3201173663 cites W2150997370 @default.
- W3201173663 cites W2154152972 @default.
- W3201173663 cites W2155165473 @default.
- W3201173663 cites W2164723344 @default.
- W3201173663 cites W2169846247 @default.
- W3201173663 cites W2201190784 @default.
- W3201173663 cites W2203601633 @default.
- W3201173663 cites W2273918286 @default.
- W3201173663 cites W2318069817 @default.
- W3201173663 cites W2343386476 @default.
- W3201173663 cites W2345688749 @default.
- W3201173663 cites W2439803058 @default.
- W3201173663 cites W2516200712 @default.
- W3201173663 cites W2520654044 @default.
- W3201173663 cites W2550790024 @default.
- W3201173663 cites W2575479581 @default.
- W3201173663 cites W2592173429 @default.
- W3201173663 cites W2592248309 @default.
- W3201173663 cites W2622796688 @default.
- W3201173663 cites W2624831991 @default.
- W3201173663 cites W2729371963 @default.
- W3201173663 cites W2747215423 @default.
- W3201173663 cites W2751301707 @default.
- W3201173663 cites W2764340845 @default.
- W3201173663 cites W2766948867 @default.
- W3201173663 cites W2770323050 @default.
- W3201173663 cites W2799981419 @default.
- W3201173663 cites W2809580703 @default.
- W3201173663 cites W2809698015 @default.
- W3201173663 cites W2881212502 @default.
- W3201173663 cites W2885863338 @default.
- W3201173663 cites W2900068404 @default.