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- W3201210350 endingPage "1277" @default.
- W3201210350 startingPage "1268" @default.
- W3201210350 abstract "Abstract Endogenous DNA damage is a major contributor to mutations, which are drivers of cancer development. Bromodomain (BRD) proteins are well-established participants in chromatin-based DNA damage response (DDR) pathways, which maintain genome integrity from cell-intrinsic and extrinsic DNA-damaging sources. BRD proteins are most well-studied as regulators of transcription, but emerging evidence has revealed their importance in other DNA-templated processes, including DNA repair and replication. How BRD proteins mechanistically protect cells from endogenous DNA damage through their participation in these pathways remains an active area of investigation. Here, we review several recent studies establishing BRD proteins as key influencers of endogenous DNA damage, including DNA–RNA hybrid (R-loops) formation during transcription and participation in replication stress responses. As endogenous DNA damage is known to contribute to several human diseases, including neurodegeneration, immunodeficiencies, cancer, and aging, the ability of BRD proteins to suppress DNA damage and mutations is likely to provide new insights into the involvement of BRD proteins in these diseases. Although many studies have focused on BRD proteins in transcription, evidence indicates that BRD proteins have emergent functions in DNA repair and genome stability and are participants in the etiology and treatment of diseases involving endogenous DNA damage." @default.
- W3201210350 created "2021-09-27" @default.
- W3201210350 creator A5009031239 @default.
- W3201210350 creator A5061589901 @default.
- W3201210350 creator A5089103469 @default.
- W3201210350 date "2021-09-01" @default.
- W3201210350 modified "2023-10-12" @default.
- W3201210350 title "Bromodomain proteins: protectors against endogenous DNA damage and facilitators of genome integrity" @default.
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