Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201212345> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3201212345 endingPage "70" @default.
- W3201212345 startingPage "63" @default.
- W3201212345 abstract "Abstract In recent years, ALR2 (aldose reductase) inhibitors have attracted attention for their effective ability to reduce the progression of diabetes-associated cataracts. Therefore, in the present article, we intended to develop novel thiazole-sulfonamide hybrids as a potent inhibitor of ALR2. These molecules significantly inhibited the ALR2 level in the rat lenses homogenate, where the most potent compound 7b showed activity comparable to sorbinil as standard. In Wistar rats, compound 7b improved the insulin level and body weight of the experimental animal together with a reduction in the glucose output. Compound 7b showed a significant reduction in the expression of ALR2 in rat lenses in western blot analysis." @default.
- W3201212345 created "2021-09-27" @default.
- W3201212345 creator A5014091064 @default.
- W3201212345 creator A5029714687 @default.
- W3201212345 creator A5030754445 @default.
- W3201212345 date "2021-01-01" @default.
- W3201212345 modified "2023-10-18" @default.
- W3201212345 title "Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase" @default.
- W3201212345 cites W1990956235 @default.
- W3201212345 cites W2010200420 @default.
- W3201212345 cites W2040227483 @default.
- W3201212345 cites W2066746672 @default.
- W3201212345 cites W2087195209 @default.
- W3201212345 cites W2131942336 @default.
- W3201212345 cites W2154789716 @default.
- W3201212345 cites W2157757005 @default.
- W3201212345 cites W2175794497 @default.
- W3201212345 cites W2418293022 @default.
- W3201212345 cites W2460530547 @default.
- W3201212345 cites W2773556861 @default.
- W3201212345 cites W2790171699 @default.
- W3201212345 cites W2791236688 @default.
- W3201212345 cites W2896134117 @default.
- W3201212345 cites W2921119611 @default.
- W3201212345 cites W2936015784 @default.
- W3201212345 cites W2952166462 @default.
- W3201212345 cites W2952656992 @default.
- W3201212345 cites W3014657444 @default.
- W3201212345 cites W4233915931 @default.
- W3201212345 doi "https://doi.org/10.1515/hc-2020-0124" @default.
- W3201212345 hasPublicationYear "2021" @default.
- W3201212345 type Work @default.
- W3201212345 sameAs 3201212345 @default.
- W3201212345 citedByCount "2" @default.
- W3201212345 countsByYear W32012123452023 @default.
- W3201212345 crossrefType "journal-article" @default.
- W3201212345 hasAuthorship W3201212345A5014091064 @default.
- W3201212345 hasAuthorship W3201212345A5029714687 @default.
- W3201212345 hasAuthorship W3201212345A5030754445 @default.
- W3201212345 hasConcept C118487528 @default.
- W3201212345 hasConcept C181199279 @default.
- W3201212345 hasConcept C185592680 @default.
- W3201212345 hasConcept C2776439734 @default.
- W3201212345 hasConcept C2776614240 @default.
- W3201212345 hasConcept C2777374081 @default.
- W3201212345 hasConcept C2778464347 @default.
- W3201212345 hasConcept C2780225610 @default.
- W3201212345 hasConcept C2781039511 @default.
- W3201212345 hasConcept C55493867 @default.
- W3201212345 hasConcept C71240020 @default.
- W3201212345 hasConcept C71924100 @default.
- W3201212345 hasConcept C98274493 @default.
- W3201212345 hasConceptScore W3201212345C118487528 @default.
- W3201212345 hasConceptScore W3201212345C181199279 @default.
- W3201212345 hasConceptScore W3201212345C185592680 @default.
- W3201212345 hasConceptScore W3201212345C2776439734 @default.
- W3201212345 hasConceptScore W3201212345C2776614240 @default.
- W3201212345 hasConceptScore W3201212345C2777374081 @default.
- W3201212345 hasConceptScore W3201212345C2778464347 @default.
- W3201212345 hasConceptScore W3201212345C2780225610 @default.
- W3201212345 hasConceptScore W3201212345C2781039511 @default.
- W3201212345 hasConceptScore W3201212345C55493867 @default.
- W3201212345 hasConceptScore W3201212345C71240020 @default.
- W3201212345 hasConceptScore W3201212345C71924100 @default.
- W3201212345 hasConceptScore W3201212345C98274493 @default.
- W3201212345 hasIssue "1" @default.
- W3201212345 hasLocation W32012123451 @default.
- W3201212345 hasOpenAccess W3201212345 @default.
- W3201212345 hasPrimaryLocation W32012123451 @default.
- W3201212345 hasRelatedWork W1553699181 @default.
- W3201212345 hasRelatedWork W15777863 @default.
- W3201212345 hasRelatedWork W1989470630 @default.
- W3201212345 hasRelatedWork W203429344 @default.
- W3201212345 hasRelatedWork W2090943274 @default.
- W3201212345 hasRelatedWork W2093648111 @default.
- W3201212345 hasRelatedWork W3105875909 @default.
- W3201212345 hasRelatedWork W3201212345 @default.
- W3201212345 hasRelatedWork W48460700 @default.
- W3201212345 hasRelatedWork W6926258 @default.
- W3201212345 hasVolume "27" @default.
- W3201212345 isParatext "false" @default.
- W3201212345 isRetracted "false" @default.
- W3201212345 magId "3201212345" @default.
- W3201212345 workType "article" @default.