FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201214810> ?p ?o ?g. }

• W3201214810 endingPage "e402" @default.
• W3201214810 startingPage "e401" @default.
• W3201214810 abstract "We have previously demonstrated that the frequency of individual chromosomal copy number variations identified in human embryos cultured in vitro mirrors those found following early pregnancy loss.1 It is unclear whether the same chromosomal abnormalities are identified in mosaic embryos. The aim of this study is to determine the frequency of individual chromosomal anomalies in aneuploid versus mosaic embryos. This study included patients who underwent IVF with preimplantation genetic testing for aneuploidy (PGT-A) at a single academic center from January 2020 through March 2021. Trophectoderm biopsies were analyzed using a modified FAST-SeqS NGS-based PGT method and bioinformatics pipeline, which detects whole chromosome and segmental aneuploidies (≥10Mb), most types of polyploidy, and many instances of single chromosome uniparental isodisomy through amplification of L1 sites. The reported chromosome complement for each embryo was analyzed. The prevalence of abnormalities for each chromosome among aneuploid and mosaic embryos was determined and compared using chi-square. Bonferroni correction was used to adjust for multiple comparisons with a corrected p value of .002. A total of 7,872 embryos from 1,371 patients were included in the study with a mean age of 35.9 years, including 2,763 aneuploid embryos (35.1%) and 1,035 mosaic embryos (13.1%). The chromosomes with the greatest prevalence of abnormalities among aneuploid embryos were 21 (20.6%) and 16 (17.4%) followed by 21 (12.5%) and 15 (11.0%). The lowest prevalences were seen in chromosomes 17 (2.9%) and 12 (2.8%). In mosaic embryos, in contrast, the variation in prevalence of anomalies per chromosome was lower, ranging from 2.4% in both chromosomes 19 and 20 to 7.1% in chromosome 6 and 8.2% in chromosome 2. When comparing the prevalence of abnormalities for each chromosome among aneuploid and mosaic embryos, significant differences were seen in chromosomes 1 (3.7% vs. 6.0%, p=.0015), 2 (4.3% vs. 8.2%, p=<.0001), 5 (3.9% vs. 6.6%, p=.0004), 6 (3.9% vs. 7.1%, p=<.0001), 15 (11.0% vs. 3.4%, p<.0001 ), 16 (17.4% vs. 3.9%, p=<.0001), 19 (6.0% vs. 2.4%, p<.0001), 20 (5.2% vs. 2.4%, p=.0002), 21 (12.5% vs. 3.6%, p<.0001), and 22 (20.6% vs. 5.7%, p<.0001). Specific chromosomes appear to have greater susceptibility to meiotic versus mitotic errors in the process of oocyte maturation and embryo development. These findings suggest that the differential mechanisms governing chromosome segregation during meiosis versus mitosis result in distinct differences in per chromosome copy number reports from embryo biopsies." @default.
• W3201214810 created "2021-09-27" @default.
• W3201214810 creator A5013959315 @default.
• W3201214810 creator A5019160234 @default.
• W3201214810 creator A5026206557 @default.
• W3201214810 creator A5033242458 @default.
• W3201214810 creator A5063987624 @default.
• W3201214810 creator A5069922999 @default.
• W3201214810 date "2021-09-01" @default.
• W3201214810 modified "2023-10-18" @default.
• W3201214810 title "PREVALENCE OF SPECIFIC CHROMOSOME-LEVEL ANOMALIES IN MOSAIC AND ANEUPLOID EMBRYOS" @default.
• W3201214810 doi "https://doi.org/10.1016/j.fertnstert.2021.07.1073" @default.
• W3201214810 hasPublicationYear "2021" @default.
• W3201214810 type Work @default.
• W3201214810 sameAs 3201214810 @default.
• W3201214810 citedByCount "0" @default.
• W3201214810 crossrefType "journal-article" @default.
• W3201214810 hasAuthorship W3201214810A5013959315 @default.
• W3201214810 hasAuthorship W3201214810A5019160234 @default.
• W3201214810 hasAuthorship W3201214810A5026206557 @default.
• W3201214810 hasAuthorship W3201214810A5033242458 @default.
• W3201214810 hasAuthorship W3201214810A5063987624 @default.
• W3201214810 hasAuthorship W3201214810A5069922999 @default.
• W3201214810 hasBestOaLocation W32012148101 @default.
• W3201214810 hasConcept C104317684 @default.
• W3201214810 hasConcept C16685009 @default.
• W3201214810 hasConcept C196843134 @default.
• W3201214810 hasConcept C2779672484 @default.
• W3201214810 hasConcept C2780332060 @default.
• W3201214810 hasConcept C30481170 @default.
• W3201214810 hasConcept C53226629 @default.
• W3201214810 hasConcept C54355233 @default.
• W3201214810 hasConcept C71924100 @default.
• W3201214810 hasConcept C86803240 @default.
• W3201214810 hasConceptScore W3201214810C104317684 @default.
• W3201214810 hasConceptScore W3201214810C16685009 @default.
• W3201214810 hasConceptScore W3201214810C196843134 @default.
• W3201214810 hasConceptScore W3201214810C2779672484 @default.
• W3201214810 hasConceptScore W3201214810C2780332060 @default.
• W3201214810 hasConceptScore W3201214810C30481170 @default.
• W3201214810 hasConceptScore W3201214810C53226629 @default.
• W3201214810 hasConceptScore W3201214810C54355233 @default.
• W3201214810 hasConceptScore W3201214810C71924100 @default.
• W3201214810 hasConceptScore W3201214810C86803240 @default.
• W3201214810 hasIssue "3" @default.
• W3201214810 hasLocation W32012148101 @default.
• W3201214810 hasOpenAccess W3201214810 @default.
• W3201214810 hasPrimaryLocation W32012148101 @default.
• W3201214810 hasRelatedWork W1543431273 @default.
• W3201214810 hasRelatedWork W169557258 @default.
• W3201214810 hasRelatedWork W1970446973 @default.
• W3201214810 hasRelatedWork W2049456474 @default.
• W3201214810 hasRelatedWork W2056998495 @default.
• W3201214810 hasRelatedWork W2088132675 @default.
• W3201214810 hasRelatedWork W2183685009 @default.
• W3201214810 hasRelatedWork W2333266556 @default.
• W3201214810 hasRelatedWork W2509202055 @default.
• W3201214810 hasRelatedWork W2982203290 @default.
• W3201214810 hasVolume "116" @default.
• W3201214810 isParatext "false" @default.
• W3201214810 isRetracted "false" @default.
• W3201214810 magId "3201214810" @default.
• W3201214810 workType "article" @default.