FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201215422> ?p ?o ?g. }

• W3201215422 endingPage "160" @default.
• W3201215422 startingPage "152" @default.
• W3201215422 abstract "The annual spread of influenza A virus (IAV) infection is a global concern. We examined the IAV-inactivating potential of theaflavin-concentrated tea extract TY-1, which contains abundant polyphenols, including concentrated theaflavins and catechins. TY-1 exhibited concentration- and time-dependent virucidal activity against IAV. Specifically, 5.0 mg/mL TY-1 induced a 1.33 and ≥ 5.17 log10 50% tissue culture infective dose/mL reduction of the viral titer compared with dextrin as the diluent control within 30 min and 6 h reaction time, respectively. The high virucidal activity of TY-1 was attributed to the combined additive activities of multiple virucidal components, including theaflavins, which led to an investigation of the virucidal mechanism of action of TY-1. Western blotting revealed that TY-1 treatment reduced the band intensity of hemagglutinin and induced the appearance of additional high molecular mass bands/ladders. In addition, TY-1 treatment also reduced the band intensity of neuraminidase (NA). A hemagglutination assay revealed that TY-1 reduced hemagglutination activity, and an NA assay revealed reduced NA activity. These results indicated that TY-1 caused structural abnormalities in IAV spike proteins, possibly leading to their destruction. Reverse transcription polymerase chain reaction (PCR) targeting the IAV genome and electron microscopic observation of viral particles revealed that upon application of TY-1, the PCR products dissipated, which indicates that TY-1 destroyed the IAV genome, and the number of viral particles reduced. Overall, TY-1 exhibited multiple modes of IAV-inactivating activity. Our findings support the possible future practical use of TY-1 as a virucidal supplemental agent that can contribute to IAV infection control." @default.
• W3201215422 created "2021-09-27" @default.
• W3201215422 creator A5010637386 @default.
• W3201215422 creator A5018625873 @default.
• W3201215422 creator A5040549451 @default.
• W3201215422 date "2021-09-22" @default.
• W3201215422 modified "2023-10-17" @default.
• W3201215422 title "In vitro virucidal activity of the theaflavin-concentrated tea extract TY-1 against influenza A virus" @default.
• W3201215422 cites W1764211945 @default.
• W3201215422 cites W1801216971 @default.
• W3201215422 cites W1941584562 @default.
• W3201215422 cites W1963657737 @default.
• W3201215422 cites W1964149587 @default.
• W3201215422 cites W1971489080 @default.
• W3201215422 cites W1978863022 @default.
• W3201215422 cites W1981591706 @default.
• W3201215422 cites W1989069389 @default.
• W3201215422 cites W2001849111 @default.
• W3201215422 cites W2041701538 @default.
• W3201215422 cites W2051405635 @default.
• W3201215422 cites W2065380210 @default.
• W3201215422 cites W2077861279 @default.
• W3201215422 cites W2080653446 @default.
• W3201215422 cites W2087410482 @default.
• W3201215422 cites W2090614994 @default.
• W3201215422 cites W2094280451 @default.
• W3201215422 cites W2117635456 @default.
• W3201215422 cites W2131087941 @default.
• W3201215422 cites W2136029777 @default.
• W3201215422 cites W2148689523 @default.
• W3201215422 cites W2150386396 @default.
• W3201215422 cites W2150892779 @default.
• W3201215422 cites W2158304436 @default.
• W3201215422 cites W2161872802 @default.
• W3201215422 cites W2172122060 @default.
• W3201215422 cites W2331211755 @default.
• W3201215422 cites W2476882219 @default.
• W3201215422 cites W2532914623 @default.
• W3201215422 cites W2559927678 @default.
• W3201215422 cites W2768371966 @default.
• W3201215422 cites W2782860618 @default.
• W3201215422 cites W2809190914 @default.
• W3201215422 cites W2902791508 @default.
• W3201215422 cites W3037481609 @default.
• W3201215422 cites W3126932844 @default.
• W3201215422 cites W3169250398 @default.
• W3201215422 doi "https://doi.org/10.1007/s11418-021-01568-0" @default.
• W3201215422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8456404" @default.
• W3201215422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34550554" @default.
• W3201215422 hasPublicationYear "2021" @default.
• W3201215422 type Work @default.
• W3201215422 sameAs 3201215422 @default.
• W3201215422 citedByCount "4" @default.
• W3201215422 countsByYear W32012154222022 @default.
• W3201215422 countsByYear W32012154222023 @default.
• W3201215422 crossrefType "journal-article" @default.
• W3201215422 hasAuthorship W3201215422A5010637386 @default.
• W3201215422 hasAuthorship W3201215422A5018625873 @default.
• W3201215422 hasAuthorship W3201215422A5040549451 @default.
• W3201215422 hasBestOaLocation W32012154221 @default.
• W3201215422 hasConcept C134164806 @default.
• W3201215422 hasConcept C159047783 @default.
• W3201215422 hasConcept C185592680 @default.
• W3201215422 hasConcept C202751555 @default.
• W3201215422 hasConcept C2522874641 @default.
• W3201215422 hasConcept C2777546802 @default.
• W3201215422 hasConcept C2778004101 @default.
• W3201215422 hasConcept C2778692840 @default.
• W3201215422 hasConcept C2780487065 @default.
• W3201215422 hasConcept C34343649 @default.
• W3201215422 hasConcept C55493867 @default.
• W3201215422 hasConcept C70899900 @default.
• W3201215422 hasConcept C86803240 @default.
• W3201215422 hasConcept C89423630 @default.
• W3201215422 hasConceptScore W3201215422C134164806 @default.
• W3201215422 hasConceptScore W3201215422C159047783 @default.
• W3201215422 hasConceptScore W3201215422C185592680 @default.
• W3201215422 hasConceptScore W3201215422C202751555 @default.
• W3201215422 hasConceptScore W3201215422C2522874641 @default.
• W3201215422 hasConceptScore W3201215422C2777546802 @default.
• W3201215422 hasConceptScore W3201215422C2778004101 @default.
• W3201215422 hasConceptScore W3201215422C2778692840 @default.
• W3201215422 hasConceptScore W3201215422C2780487065 @default.
• W3201215422 hasConceptScore W3201215422C34343649 @default.
• W3201215422 hasConceptScore W3201215422C55493867 @default.
• W3201215422 hasConceptScore W3201215422C70899900 @default.
• W3201215422 hasConceptScore W3201215422C86803240 @default.
• W3201215422 hasConceptScore W3201215422C89423630 @default.
• W3201215422 hasIssue "1" @default.
• W3201215422 hasLocation W32012154221 @default.
• W3201215422 hasLocation W32012154222 @default.
• W3201215422 hasLocation W32012154223 @default.
• W3201215422 hasOpenAccess W3201215422 @default.
• W3201215422 hasPrimaryLocation W32012154221 @default.
• W3201215422 hasRelatedWork W1528684958 @default.
• W3201215422 hasRelatedWork W1606538280 @default.
• W3201215422 hasRelatedWork W1990428998 @default.
• W3201215422 hasRelatedWork W2036315754 @default.

• next