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- W3201216418 endingPage "1928" @default.
- W3201216418 startingPage "1928" @default.
- W3201216418 abstract "Comparative genomics, in particular, pan-genome analysis, provides an in-depth understanding of the genetic variability and dynamics of a bacterial species. Coupled with whole-genome-based taxonomic analysis, these approaches can help to provide comprehensive, detailed insights into a bacterial species. Here, we report whole-genome-based taxonomic classification and comparative genomic analysis of potential human pathogenic Enterobacter hormaechei subsp. hoffmannii isolated from chlorinated wastewater. Genome Blast Distance Phylogeny (GBDP), digital DNA-DNA hybridization (dDDH), and average nucleotide identity (ANI) confirmed the identity of the isolates. The algorithm PathogenFinder predicted the isolates to be human pathogens with a probability of greater than 0.78. The potential pathogenic nature of the isolates was supported by the presence of biosynthetic gene clusters (BGCs), aerobactin, and aryl polyenes (APEs), which are known to be associated with pathogenic/virulent strains. Moreover, analysis of the genome sequences of the isolates reflected the presence of an arsenal of virulence factors and antibiotic resistance genes that augment the predictions of the algorithm PathogenFinder. The study comprehensively elucidated the genomic features of pathogenic Enterobacter isolates from wastewaters, highlighting the role of wastewaters in the dissemination of pathogenic microbes, and the need for monitoring the effectiveness of the wastewater treatment process." @default.
- W3201216418 created "2021-09-27" @default.
- W3201216418 creator A5049226386 @default.
- W3201216418 creator A5063053009 @default.
- W3201216418 date "2021-09-10" @default.
- W3201216418 modified "2023-09-23" @default.
- W3201216418 title "Whole Genome Sequencing Based Taxonomic Classification, and Comparative Genomic Analysis of Potentially Human Pathogenic Enterobacter spp. Isolated from Chlorinated Wastewater in the North West Province, South Africa" @default.
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- W3201216418 doi "https://doi.org/10.3390/microorganisms9091928" @default.
- W3201216418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8466087" @default.
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- W3201216418 hasPublicationYear "2021" @default.
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