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- W3201218862 abstract "The design and implementation of synthetic circuits that operate robustly in the cellular context is fundamental for the advancement of synthetic biology. However, their practical implementation presents challenges due to low predictability of synthetic circuit design and time-intensive troubleshooting. Here, we present the Cyberloop, a testing framework to accelerate the design process and implementation of biomolecular controllers. Cellular fluorescence measurements are sent in real-time to a computer simulating candidate stochastic controllers, which in turn compute the control inputs and feed them back to the controlled cells via light stimulation. Applying this framework to yeast cells engineered with optogenetic tools, we examine and characterize different biomolecular controllers, test the impact of non-ideal circuit behaviors such as dilution on their operation, and qualitatively demonstrate improvements in controller function with certain network modifications. From this analysis, we derive conditions for desirable biomolecular controller performance, thereby avoiding pitfalls during its biological implementation." @default.
- W3201218862 created "2021-09-27" @default.
- W3201218862 creator A5018485369 @default.
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- W3201218862 date "2021-09-24" @default.
- W3201218862 modified "2023-10-13" @default.
- W3201218862 title "Rapid prototyping and design of cybergenetic single-cell controllers" @default.
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- W3201218862 doi "https://doi.org/10.1038/s41467-021-25754-6" @default.
- W3201218862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8463601" @default.
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