FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201219587> ?p ?o ?g. }

• W3201219587 endingPage "4129" @default.
• W3201219587 startingPage "4129" @default.
• W3201219587 abstract "Introduction: Obesity, which is a serious problem in children, has a negative impact on many organs, including kidneys, and obesity-related glomerulopathy (ORG) is an increasingly common cause of ESKD (end-stage kidney disease) in adults. Early-detected and -treated glomerular lesions are reversible, so it is important to find a useful marker of early damage. The study aimed to evaluate the albumin-to-creatinine ratio (ACR), urinary alpha-1-acid glycoprotein (α1-AGP), and mRNA of podocyte-specific proteins as indicators of glomerular injury and their relationship with the degree of obesity and metabolic disorders. Materials and Methods: A total of 125 obese children and 33 healthy peers were enrolled. Patients were divided into two groups, depending on SDS BMI values. ACR, α1-AGP, mRNA expression of nephrin, synaptopodin, podocin, and C2AP protein in urine sediment were measured. Results: ACR values did not differ between groups and were within the normal range. α1-AGP and mRNA expression were significantly higher in obese children compared with controls. mRNA expression of the remaining podocyte proteins was similar in both groups. No significant differences concerning all examined parameters were found depending on the degree of obesity. There was a positive significant correlation between α1-AGP and ACR. Conclusions: Increased α1-AGP before the onset of albuminuria suggests its usefulness as a biomarker of early glomerular damage in obese children. An increased podocin mRNA expression also indicates podocyte damage and may be linked to ORG development. The lack of increase in expression of other podocyte proteins suggests that podocin mRNA may be a more specific and sensitive biomarker. The degree of obesity has no impact on the tested parameters, but further studies are needed to confirm it." @default.
• W3201219587 created "2021-09-27" @default.
• W3201219587 creator A5026632953 @default.
• W3201219587 creator A5038384785 @default.
• W3201219587 creator A5068371444 @default.
• W3201219587 creator A5070150486 @default.
• W3201219587 creator A5081184240 @default.
• W3201219587 creator A5082508055 @default.
• W3201219587 date "2021-09-13" @default.
• W3201219587 modified "2023-10-16" @default.
• W3201219587 title "Alpha-1 Acid Glycoprotein and Podocin mRNA as Novel Biomarkers for Early Glomerular Injury in Obese Children" @default.
• W3201219587 cites W1960255425 @default.
• W3201219587 cites W1965785889 @default.
• W3201219587 cites W1973049671 @default.
• W3201219587 cites W1986834239 @default.
• W3201219587 cites W1988537627 @default.
• W3201219587 cites W1991081852 @default.
• W3201219587 cites W2013829288 @default.
• W3201219587 cites W2027127101 @default.
• W3201219587 cites W2035639607 @default.
• W3201219587 cites W2036990714 @default.
• W3201219587 cites W2059064504 @default.
• W3201219587 cites W2059194533 @default.
• W3201219587 cites W2084497043 @default.
• W3201219587 cites W2100793130 @default.
• W3201219587 cites W2102989684 @default.
• W3201219587 cites W2110245532 @default.
• W3201219587 cites W2116527412 @default.
• W3201219587 cites W2142165469 @default.
• W3201219587 cites W2160460706 @default.
• W3201219587 cites W2308295330 @default.
• W3201219587 cites W2314867211 @default.
• W3201219587 cites W2582613914 @default.
• W3201219587 cites W2602437443 @default.
• W3201219587 cites W2808599070 @default.
• W3201219587 cites W2897526508 @default.
• W3201219587 cites W2964394365 @default.
• W3201219587 cites W2964681741 @default.
• W3201219587 cites W3005514510 @default.
• W3201219587 cites W3134734314 @default.
• W3201219587 doi "https://doi.org/10.3390/jcm10184129" @default.
• W3201219587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8472314" @default.
• W3201219587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34575240" @default.
• W3201219587 hasPublicationYear "2021" @default.
• W3201219587 type Work @default.
• W3201219587 sameAs 3201219587 @default.
• W3201219587 citedByCount "6" @default.
• W3201219587 countsByYear W32012195872022 @default.
• W3201219587 countsByYear W32012195872023 @default.
• W3201219587 crossrefType "journal-article" @default.
• W3201219587 hasAuthorship W3201219587A5026632953 @default.
• W3201219587 hasAuthorship W3201219587A5038384785 @default.
• W3201219587 hasAuthorship W3201219587A5068371444 @default.
• W3201219587 hasAuthorship W3201219587A5070150486 @default.
• W3201219587 hasAuthorship W3201219587A5081184240 @default.
• W3201219587 hasAuthorship W3201219587A5082508055 @default.
• W3201219587 hasBestOaLocation W32012195871 @default.
• W3201219587 hasConcept C126322002 @default.
• W3201219587 hasConcept C134018914 @default.
• W3201219587 hasConcept C159641895 @default.
• W3201219587 hasConcept C20299238 @default.
• W3201219587 hasConcept C2776174234 @default.
• W3201219587 hasConcept C2776855237 @default.
• W3201219587 hasConcept C2777146197 @default.
• W3201219587 hasConcept C2779561371 @default.
• W3201219587 hasConcept C2780091579 @default.
• W3201219587 hasConcept C2780199430 @default.
• W3201219587 hasConcept C2780306776 @default.
• W3201219587 hasConcept C2780368995 @default.
• W3201219587 hasConcept C2780819817 @default.
• W3201219587 hasConcept C2781197716 @default.
• W3201219587 hasConcept C55493867 @default.
• W3201219587 hasConcept C71924100 @default.
• W3201219587 hasConcept C86803240 @default.
• W3201219587 hasConceptScore W3201219587C126322002 @default.
• W3201219587 hasConceptScore W3201219587C134018914 @default.
• W3201219587 hasConceptScore W3201219587C159641895 @default.
• W3201219587 hasConceptScore W3201219587C20299238 @default.
• W3201219587 hasConceptScore W3201219587C2776174234 @default.
• W3201219587 hasConceptScore W3201219587C2776855237 @default.
• W3201219587 hasConceptScore W3201219587C2777146197 @default.
• W3201219587 hasConceptScore W3201219587C2779561371 @default.
• W3201219587 hasConceptScore W3201219587C2780091579 @default.
• W3201219587 hasConceptScore W3201219587C2780199430 @default.
• W3201219587 hasConceptScore W3201219587C2780306776 @default.
• W3201219587 hasConceptScore W3201219587C2780368995 @default.
• W3201219587 hasConceptScore W3201219587C2780819817 @default.
• W3201219587 hasConceptScore W3201219587C2781197716 @default.
• W3201219587 hasConceptScore W3201219587C55493867 @default.
• W3201219587 hasConceptScore W3201219587C71924100 @default.
• W3201219587 hasConceptScore W3201219587C86803240 @default.
• W3201219587 hasIssue "18" @default.
• W3201219587 hasLocation W32012195871 @default.
• W3201219587 hasLocation W32012195872 @default.
• W3201219587 hasLocation W32012195873 @default.
• W3201219587 hasLocation W32012195874 @default.
• W3201219587 hasOpenAccess W3201219587 @default.
• W3201219587 hasPrimaryLocation W32012195871 @default.

• next