FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201220914> ?p ?o ?g. }

• W3201220914 endingPage "e9" @default.
• W3201220914 startingPage "e9" @default.
• W3201220914 abstract "Statins are used with the understanding that a slightly increased risk of diabetes is outweighed by their cardiovascular benefits. However, it may be necessary to reconsider whether statin therapy really increase this risk mainly in the population with prediabetes.A multicenter, cross-sectional, observational study was conducted to assess the relationship between statin therapy and glucose metabolism in 407 patients aged 63.1 years (11SD) diagnosed with dyslipidemia and prediabetes treated in specialized lipid clinics in Spain.Significant differences were found in HbA1c values among treatment groups (p = 0.015). Patients treated with pitavastatin (1–4 mg/day) showed the lowest HbA1c levels, with significant differences compared to patients treated with atorvastatin 40–80 mg/day (p = 0.016) and simvastatin 10–40 mg/day (p = 0.036). By contrast, patients treated with atorvastatin 40–80 mg/day showed the highest HbA1c levels compared to those receiving atorvastatin 10–20 mg/day (p = 0.003), pitavastatin 1–4 mg/day (p = 0.016), pravastatin 20–40 mg/day (p = 0.027), rosuvastatin 5–10 mg/day (p = 0.043), and no statin treatment (p = 0.004). Patients treated with simvastatin 10–40 mg/day also had higher values than those treated with atorvastatin 10–20 mg/day (p = 0.016) and pitavastatin 1–4 mg/day (p = 0.036) or with no statin treatment (p = 0.018).This study suggests that there are differences in the diabetogenic effect of statins. Simvastatin and high doses of atorvastatin may be associated with greater impairment in glucose metabolism than pitavastatin and other statins with less lipid-lowering potency such as pravastatin.Las estatinas son utilizadas de acuerdo con el entendimiento de que el pequeño riesgo de incremento de diabetes se ve compensado por sus beneficios cardiovasculares. Sin embargo, puede resultar necesario reconsiderar si la terapia con estatinas incrementa realmente el riesgo, principalmente en la población con prediabetes.Se realizó un estudio multicéntrico, transversal y observacional para evaluar la relación entre la terapia con estatinas y el metabolismo de la glucosa en 407 pacientes de 63,1 años (11 DE) diagnosticados de dislipidemia y prediabetes tratados en clínicas especializadas en lípidos en España.Se encontraron diferencias significativas en los valores de HbA1c entre los grupos de tratamiento (p = 0,015). Los pacientes tratados con pitavastatina (1-4 mg/día) reflejaron los menores niveles de HbA1c, con diferencias significativas en comparación con los pacientes tratados con atorvastatina 40-80 mg/día (p = 0,016) y simvastatina 10-40 mg/día (p = 0,036). Por contra, los pacientes tratados con atorvastatina 40-80 mg/día reflejaron los mayores niveles de HbA1c en comparación con los pacientes que recibieron atorvastatina 10-20 mg/día (p = 0,003), pitavastatina 1-4 mg/día (p = 0,016), pravastatina 20-40 mg/día (p = 0,027), rosuvastatina 5-10 mg/día (p = 0,043) y los que no recibieron estatinas (p = 0,004). Los pacientes tratados con simvastatina 10-40 mg/día tuvieron también valores más elevados que aquellos pacientes tratados con atorvastatina 10-20 mg/día (p = 0,016) y pitavastatina 1-4 mg/día (p = 0,036) que no recibieron estatinas (p = 0,018).El presente estudio sugiere que existen diferencias en cuanto al efecto diabetógeno de las estatinas. Simvastatina y las altas dosis de atorvastatina pueden guardar relación con un mayor deterioro del metabolismo de la glucosa que pitavastatina y demás estatinas con menor potencia de reducción de lípidos, tales como pravastatina." @default.
• W3201220914 created "2021-09-27" @default.
• W3201220914 creator A5057937997 @default.
• W3201220914 date "2021-09-01" @default.
• W3201220914 modified "2023-10-02" @default.
• W3201220914 title "SY6-1. Statins for preeclampsia" @default.
• W3201220914 doi "https://doi.org/10.1016/j.preghy.2021.07.274" @default.
• W3201220914 hasPublicationYear "2021" @default.
• W3201220914 type Work @default.
• W3201220914 sameAs 3201220914 @default.
• W3201220914 citedByCount "0" @default.
• W3201220914 crossrefType "journal-article" @default.
• W3201220914 hasAuthorship W3201220914A5057937997 @default.
• W3201220914 hasConcept C104950815 @default.
• W3201220914 hasConcept C126322002 @default.
• W3201220914 hasConcept C134018914 @default.
• W3201220914 hasConcept C134651460 @default.
• W3201220914 hasConcept C181199279 @default.
• W3201220914 hasConcept C185592680 @default.
• W3201220914 hasConcept C2776329913 @default.
• W3201220914 hasConcept C2776692505 @default.
• W3201220914 hasConcept C2776839432 @default.
• W3201220914 hasConcept C2777180221 @default.
• W3201220914 hasConcept C2777482532 @default.
• W3201220914 hasConcept C2778096610 @default.
• W3201220914 hasConcept C2778163477 @default.
• W3201220914 hasConcept C2779519902 @default.
• W3201220914 hasConcept C2779668308 @default.
• W3201220914 hasConcept C2780499067 @default.
• W3201220914 hasConcept C2908647359 @default.
• W3201220914 hasConcept C55493867 @default.
• W3201220914 hasConcept C555293320 @default.
• W3201220914 hasConcept C71924100 @default.
• W3201220914 hasConcept C90924648 @default.
• W3201220914 hasConcept C99454951 @default.
• W3201220914 hasConceptScore W3201220914C104950815 @default.
• W3201220914 hasConceptScore W3201220914C126322002 @default.
• W3201220914 hasConceptScore W3201220914C134018914 @default.
• W3201220914 hasConceptScore W3201220914C134651460 @default.
• W3201220914 hasConceptScore W3201220914C181199279 @default.
• W3201220914 hasConceptScore W3201220914C185592680 @default.
• W3201220914 hasConceptScore W3201220914C2776329913 @default.
• W3201220914 hasConceptScore W3201220914C2776692505 @default.
• W3201220914 hasConceptScore W3201220914C2776839432 @default.
• W3201220914 hasConceptScore W3201220914C2777180221 @default.
• W3201220914 hasConceptScore W3201220914C2777482532 @default.
• W3201220914 hasConceptScore W3201220914C2778096610 @default.
• W3201220914 hasConceptScore W3201220914C2778163477 @default.
• W3201220914 hasConceptScore W3201220914C2779519902 @default.
• W3201220914 hasConceptScore W3201220914C2779668308 @default.
• W3201220914 hasConceptScore W3201220914C2780499067 @default.
• W3201220914 hasConceptScore W3201220914C2908647359 @default.
• W3201220914 hasConceptScore W3201220914C55493867 @default.
• W3201220914 hasConceptScore W3201220914C555293320 @default.
• W3201220914 hasConceptScore W3201220914C71924100 @default.
• W3201220914 hasConceptScore W3201220914C90924648 @default.
• W3201220914 hasConceptScore W3201220914C99454951 @default.
• W3201220914 hasLocation W32012209141 @default.
• W3201220914 hasOpenAccess W3201220914 @default.
• W3201220914 hasPrimaryLocation W32012209141 @default.
• W3201220914 hasRelatedWork W1967017916 @default.
• W3201220914 hasRelatedWork W2012262440 @default.
• W3201220914 hasRelatedWork W2022615279 @default.
• W3201220914 hasRelatedWork W2081013641 @default.
• W3201220914 hasRelatedWork W2100240490 @default.
• W3201220914 hasRelatedWork W2135973591 @default.
• W3201220914 hasRelatedWork W2164757622 @default.
• W3201220914 hasRelatedWork W3201219654 @default.
• W3201220914 hasRelatedWork W4283072942 @default.
• W3201220914 hasRelatedWork W2947959412 @default.
• W3201220914 hasVolume "25" @default.
• W3201220914 isParatext "false" @default.
• W3201220914 isRetracted "false" @default.
• W3201220914 magId "3201220914" @default.
• W3201220914 workType "article" @default.