FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W320122098> ?p ?o ?g. }

• W320122098 abstract "This study aims to explore the clinical characteristics of ABCE1 in esophageal cancers and its roles in the proliferation, invasiveness, migration and apoptosis of the esophageal carcinoma Eca109 cell line.The expression of ABCE1 and its target protein-RNase L, were first studied in tumor tissues of esophageal carcinoma and adjacent non-tumor tissues. The siRNA green fluorescent protein (GFP) expression vector of ABCE1 was prepared and transfected into the esophageal carcinoma Eca109 cells, then the fluorescence microscope was used to study the transfection efficiency. The MTT assay, cell invasion, the transwell and scratch assay were used to study cell proliferation and migration activity; the apoptosis rate was tested by flow cytometry. Western blot and RT-PCR assay were adopted to measure their silencing efficacy.ABCE1 expression is low in the adjacent non-tumor tissues while the expression is high in the esophageal carcinoma; the expression is reversely proportional to the differentiation degrees. The expression of RNase L was in contrary to ABCE1. After transfected with ABCE1-siRNA, the proliferation, invasiveness and migration capabilities of cells decreased significantly whilst the apoptosis rate enhanced greatly (P<0.01). Meanwhile, the expression of ABCE1 in Eca109 cells was blocked (P<0.01) while the expression of RNase L increased significantly (P<0.01).ABCE1 is closely connected with the pathogenesis and development of esophageal carcinoma, which act through the cellular pathways of 2-5A/RNase L." @default.
• W320122098 created "2016-06-24" @default.
• W320122098 creator A5007549824 @default.
• W320122098 creator A5034497791 @default.
• W320122098 creator A5059260716 @default.
• W320122098 creator A5061765389 @default.
• W320122098 creator A5062240886 @default.
• W320122098 date "2014-01-01" @default.
• W320122098 modified "2023-10-05" @default.
• W320122098 title "Depleting ABCE1 expression induces apoptosis and inhibits the ability of proliferation and migration of human esophageal carcinoma cells." @default.
• W320122098 cites W1971561964 @default.
• W320122098 cites W1983786087 @default.
• W320122098 cites W1985731587 @default.
• W320122098 cites W1993969571 @default.
• W320122098 cites W1995767101 @default.
• W320122098 cites W1999674512 @default.
• W320122098 cites W2014250634 @default.
• W320122098 cites W2015700336 @default.
• W320122098 cites W2032884648 @default.
• W320122098 cites W2033234643 @default.
• W320122098 cites W2043103956 @default.
• W320122098 cites W2064544099 @default.
• W320122098 cites W2082811085 @default.
• W320122098 cites W2091958786 @default.
• W320122098 cites W2098556555 @default.
• W320122098 cites W2100623352 @default.
• W320122098 cites W2138198587 @default.
• W320122098 cites W2147686705 @default.
• W320122098 cites W2149444093 @default.
• W320122098 cites W2156798752 @default.
• W320122098 cites W2157471770 @default.
• W320122098 cites W2158314261 @default.
• W320122098 cites W2467333799 @default.
• W320122098 cites W298729516 @default.
• W320122098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3925902" @default.
• W320122098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24551278" @default.
• W320122098 hasPublicationYear "2014" @default.
• W320122098 type Work @default.
• W320122098 sameAs 320122098 @default.
• W320122098 citedByCount "8" @default.
• W320122098 countsByYear W3201220982014 @default.
• W320122098 countsByYear W3201220982015 @default.
• W320122098 countsByYear W3201220982016 @default.
• W320122098 countsByYear W3201220982018 @default.
• W320122098 countsByYear W3201220982019 @default.
• W320122098 countsByYear W3201220982022 @default.
• W320122098 countsByYear W3201220982023 @default.
• W320122098 crossrefType "journal-article" @default.
• W320122098 hasAuthorship W320122098A5007549824 @default.
• W320122098 hasAuthorship W320122098A5034497791 @default.
• W320122098 hasAuthorship W320122098A5059260716 @default.
• W320122098 hasAuthorship W320122098A5061765389 @default.
• W320122098 hasAuthorship W320122098A5062240886 @default.
• W320122098 hasConcept C104317684 @default.
• W320122098 hasConcept C119056186 @default.
• W320122098 hasConcept C137738243 @default.
• W320122098 hasConcept C153911025 @default.
• W320122098 hasConcept C190283241 @default.
• W320122098 hasConcept C2776415932 @default.
• W320122098 hasConcept C502942594 @default.
• W320122098 hasConcept C54009773 @default.
• W320122098 hasConcept C54355233 @default.
• W320122098 hasConcept C553184892 @default.
• W320122098 hasConcept C55493867 @default.
• W320122098 hasConcept C62112901 @default.
• W320122098 hasConcept C81885089 @default.
• W320122098 hasConcept C86803240 @default.
• W320122098 hasConceptScore W320122098C104317684 @default.
• W320122098 hasConceptScore W320122098C119056186 @default.
• W320122098 hasConceptScore W320122098C137738243 @default.
• W320122098 hasConceptScore W320122098C153911025 @default.
• W320122098 hasConceptScore W320122098C190283241 @default.
• W320122098 hasConceptScore W320122098C2776415932 @default.
• W320122098 hasConceptScore W320122098C502942594 @default.
• W320122098 hasConceptScore W320122098C54009773 @default.
• W320122098 hasConceptScore W320122098C54355233 @default.
• W320122098 hasConceptScore W320122098C553184892 @default.
• W320122098 hasConceptScore W320122098C55493867 @default.
• W320122098 hasConceptScore W320122098C62112901 @default.
• W320122098 hasConceptScore W320122098C81885089 @default.
• W320122098 hasConceptScore W320122098C86803240 @default.
• W320122098 hasLocation W3201220981 @default.
• W320122098 hasOpenAccess W320122098 @default.
• W320122098 hasPrimaryLocation W3201220981 @default.
• W320122098 hasRelatedWork W1993001511 @default.
• W320122098 hasRelatedWork W2000192089 @default.
• W320122098 hasRelatedWork W2014250634 @default.
• W320122098 hasRelatedWork W2098556555 @default.
• W320122098 hasRelatedWork W2163691988 @default.
• W320122098 hasRelatedWork W2397830969 @default.
• W320122098 hasRelatedWork W2403231913 @default.
• W320122098 hasRelatedWork W2433150557 @default.
• W320122098 hasRelatedWork W2461848409 @default.
• W320122098 hasRelatedWork W2507608977 @default.
• W320122098 hasRelatedWork W2558536509 @default.
• W320122098 hasRelatedWork W2981625050 @default.
• W320122098 hasRelatedWork W3028823429 @default.
• W320122098 hasRelatedWork W3029085586 @default.
• W320122098 hasRelatedWork W3029272134 @default.
• W320122098 hasRelatedWork W3029548421 @default.

• next