FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201225624> ?p ?o ?g. }

• W3201225624 endingPage "3742" @default.
• W3201225624 startingPage "3729" @default.
• W3201225624 abstract "Half-sandwich RuII complexes, [(YZ)RuII (η6 -arene)(X)]+, (YZ=chelating bidentate ligand, X=halide), with N,N and N,O coordination (1-9) show significant antiproliferative activity against the metastatic triple-negative breast carcinoma (MDA-MB-231). 3-aminobenzoic acid or its methyl ester is used in all the ligands while varying the aldehyde for N,N and N,O coordination. In the N,N coordinated complex the coordinated halide(X) is varied for enhancing stability in solution (X=Cl, I). Rapid aquation and halide exchange of the pyridine analogues, 2 and 3, in solution are a major bane towards their antiproliferative activity. Presence of free -COOH group (1 and 4) make complexes hydrophilic and reduces toxicity. The imidazolyl 3-aminobenzoate based N,N coordinated 5 and 6 display better solution stability and efficient antiproliferative activity (IC50 ca. 2.3-2.5 μM) compared to the pyridine based 2 and 3 (IC50 >100 μM) or the N,O coordinated complexes (7-9) (IC50 ca. 7-10 μM). The iodido coordinated, 6, is resistant towards aquation and halide exchange. The N,O coordinated 7-9 underwent instantaneous aquation at pH 7.4 generating monoaquated complexes stable for at least 6 h. Complexes 5 and 6, bind to 9-ethylguanine (9-EtG) showing propensity to interact with DNA bases. The complexes may kill via apoptosis as displayed from the study of 8. The change in coordination mode and the aldehyde affected the solution stability, antiproliferative activity and mechanistic pathways. The N,N coordinated (5 and 6) exhibit arrest in the G2/M phase while the N,O coordinated 8 showed arrest in the G0/G1 phase." @default.
• W3201225624 created "2021-09-27" @default.
• W3201225624 creator A5019731659 @default.
• W3201225624 creator A5022678865 @default.
• W3201225624 creator A5055748734 @default.
• W3201225624 creator A5084515236 @default.
• W3201225624 date "2021-10-11" @default.
• W3201225624 modified "2023-09-25" @default.
• W3201225624 title "Synthesis, Structure and Cytotoxicity of <i>N</i>,<i>N</i> and <i>N</i>,<i>O</i>‐Coordinated Ru^II Complexes of 3‐Aminobenzoate Schiff Bases against Triple‐negative Breast Cancer" @default.
• W3201225624 cites W1532684710 @default.
• W3201225624 cites W1757407923 @default.
• W3201225624 cites W1974077066 @default.
• W3201225624 cites W1981557521 @default.
• W3201225624 cites W2023185574 @default.
• W3201225624 cites W2023653247 @default.
• W3201225624 cites W2043465974 @default.
• W3201225624 cites W2048168597 @default.
• W3201225624 cites W2066825427 @default.
• W3201225624 cites W2069305922 @default.
• W3201225624 cites W2069305928 @default.
• W3201225624 cites W2075243573 @default.
• W3201225624 cites W2087822292 @default.
• W3201225624 cites W2089003405 @default.
• W3201225624 cites W2095569509 @default.
• W3201225624 cites W2103459003 @default.
• W3201225624 cites W2103749095 @default.
• W3201225624 cites W2109724570 @default.
• W3201225624 cites W2112253518 @default.
• W3201225624 cites W2126695283 @default.
• W3201225624 cites W2129213133 @default.
• W3201225624 cites W2149626441 @default.
• W3201225624 cites W2165632767 @default.
• W3201225624 cites W2324460592 @default.
• W3201225624 cites W2325810989 @default.
• W3201225624 cites W2419256959 @default.
• W3201225624 cites W2465606069 @default.
• W3201225624 cites W2471747963 @default.
• W3201225624 cites W2509122025 @default.
• W3201225624 cites W2520732091 @default.
• W3201225624 cites W2621428299 @default.
• W3201225624 cites W2726771194 @default.
• W3201225624 cites W2768366028 @default.
• W3201225624 cites W2770473333 @default.
• W3201225624 cites W2785900358 @default.
• W3201225624 cites W2787263985 @default.
• W3201225624 cites W2794938872 @default.
• W3201225624 cites W2795923406 @default.
• W3201225624 cites W2796274384 @default.
• W3201225624 cites W2801182205 @default.
• W3201225624 cites W2801892794 @default.
• W3201225624 cites W2807624446 @default.
• W3201225624 cites W2808654802 @default.
• W3201225624 cites W2811343914 @default.
• W3201225624 cites W2864315291 @default.
• W3201225624 cites W2883461600 @default.
• W3201225624 cites W2885264971 @default.
• W3201225624 cites W2895214712 @default.
• W3201225624 cites W2895570462 @default.
• W3201225624 cites W2896130004 @default.
• W3201225624 cites W2896181316 @default.
• W3201225624 cites W2898355107 @default.
• W3201225624 cites W2899830841 @default.
• W3201225624 cites W2900984356 @default.
• W3201225624 cites W2901753396 @default.
• W3201225624 cites W2906995004 @default.
• W3201225624 cites W2907731725 @default.
• W3201225624 cites W2908583768 @default.
• W3201225624 cites W2914849075 @default.
• W3201225624 cites W2922309382 @default.
• W3201225624 cites W2925817352 @default.
• W3201225624 cites W2925935485 @default.
• W3201225624 cites W2945041466 @default.
• W3201225624 cites W2953479866 @default.
• W3201225624 cites W2953603674 @default.
• W3201225624 cites W2963673788 @default.
• W3201225624 cites W2965095005 @default.
• W3201225624 cites W2970215150 @default.
• W3201225624 cites W2971302725 @default.
• W3201225624 cites W2974331924 @default.
• W3201225624 cites W2980558937 @default.
• W3201225624 cites W2981635479 @default.
• W3201225624 cites W2982392611 @default.
• W3201225624 cites W3007131209 @default.
• W3201225624 cites W3013417361 @default.
• W3201225624 cites W3014489507 @default.
• W3201225624 cites W3016479875 @default.
• W3201225624 cites W3127788731 @default.
• W3201225624 cites W4240921860 @default.
• W3201225624 doi "https://doi.org/10.1002/asia.202100917" @default.
• W3201225624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34549886" @default.
• W3201225624 hasPublicationYear "2021" @default.
• W3201225624 type Work @default.
• W3201225624 sameAs 3201225624 @default.
• W3201225624 citedByCount "0" @default.
• W3201225624 crossrefType "journal-article" @default.
• W3201225624 hasAuthorship W3201225624A5019731659 @default.
• W3201225624 hasAuthorship W3201225624A5022678865 @default.
• W3201225624 hasAuthorship W3201225624A5055748734 @default.

• next