Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201230890> ?p ?o ?g. }
- W3201230890 endingPage "49" @default.
- W3201230890 startingPage "41" @default.
- W3201230890 abstract "Alcohol dependence is a chronic relapsing mental disorder with heterogeneous and complex underlying biology. It is frequently associated with nicotine dependence, severity of alcohol dependence symptoms, and diverse alcohol-related phenotypes, including the presence of delirium tremens and withdrawal symptoms, early or late onset of alcohol abuse, aggression, suicidal behavior, and anxiety. While searching for peripheral biomarkers of altered serotonergic (5-HT) function in alcohol dependence and alcohol-related behaviors, we determined a peripheral biomarker, i.e., platelet 5-HT concentration in a large group of Caucasian subjects with alcohol dependence subdivided according to the presence of specific alcohol-related phenotypes and smoking status. Individuals with alcohol dependence (n = 661) of both sexes were evaluated using Structural Clinical Interview based on DSM-IV criteria, while platelet 5-HT concentration was determined using the spectrophotofluorimetric method. Smoking is significantly associated, while sex and age are not, with platelet 5-HT concentration. Severe alcohol dependence and lack of withdrawal symptoms were associated with significantly decreased platelet 5-HT concentration in alcohol-dependent non-smokers. In smokers, significantly lower platelet 5-HT concentration was found in patients with the late onset of alcohol abuse. These results suggested that platelet 5-HT concentration might be used as a peripheral marker of different alcohol-related phenotypes, after controlling for the effects of smoking and sex." @default.
- W3201230890 created "2021-09-27" @default.
- W3201230890 creator A5001894090 @default.
- W3201230890 creator A5005465511 @default.
- W3201230890 creator A5012406643 @default.
- W3201230890 creator A5030321137 @default.
- W3201230890 creator A5031621157 @default.
- W3201230890 creator A5043698235 @default.
- W3201230890 creator A5058824368 @default.
- W3201230890 creator A5075584013 @default.
- W3201230890 creator A5083512073 @default.
- W3201230890 creator A5089485050 @default.
- W3201230890 date "2021-12-01" @default.
- W3201230890 modified "2023-10-08" @default.
- W3201230890 title "Alcohol-related phenotypes and platelet serotonin concentration" @default.
- W3201230890 cites W1604487850 @default.
- W3201230890 cites W1766279608 @default.
- W3201230890 cites W1775749144 @default.
- W3201230890 cites W1811582475 @default.
- W3201230890 cites W1864068926 @default.
- W3201230890 cites W1967747555 @default.
- W3201230890 cites W1971126167 @default.
- W3201230890 cites W1975877919 @default.
- W3201230890 cites W1977465442 @default.
- W3201230890 cites W1995496865 @default.
- W3201230890 cites W2008347627 @default.
- W3201230890 cites W2010823903 @default.
- W3201230890 cites W2020357616 @default.
- W3201230890 cites W2026245891 @default.
- W3201230890 cites W2029498726 @default.
- W3201230890 cites W2041709780 @default.
- W3201230890 cites W2043779522 @default.
- W3201230890 cites W2046063132 @default.
- W3201230890 cites W2051172093 @default.
- W3201230890 cites W2051341385 @default.
- W3201230890 cites W2061541290 @default.
- W3201230890 cites W2061835259 @default.
- W3201230890 cites W2064739576 @default.
- W3201230890 cites W2066388461 @default.
- W3201230890 cites W2068366145 @default.
- W3201230890 cites W2074521546 @default.
- W3201230890 cites W2087292721 @default.
- W3201230890 cites W2087484885 @default.
- W3201230890 cites W2088355211 @default.
- W3201230890 cites W2089359161 @default.
- W3201230890 cites W2092787182 @default.
- W3201230890 cites W2093918995 @default.
- W3201230890 cites W2097638628 @default.
- W3201230890 cites W2102043603 @default.
- W3201230890 cites W2102067529 @default.
- W3201230890 cites W2114613490 @default.
- W3201230890 cites W2119710998 @default.
- W3201230890 cites W2124060070 @default.
- W3201230890 cites W2135190897 @default.
- W3201230890 cites W2136937262 @default.
- W3201230890 cites W2137558691 @default.
- W3201230890 cites W2141636993 @default.
- W3201230890 cites W2144182612 @default.
- W3201230890 cites W2150785218 @default.
- W3201230890 cites W2152633131 @default.
- W3201230890 cites W2153715594 @default.
- W3201230890 cites W2155090722 @default.
- W3201230890 cites W2155497243 @default.
- W3201230890 cites W2156074396 @default.
- W3201230890 cites W2160070901 @default.
- W3201230890 cites W2163686316 @default.
- W3201230890 cites W2167188228 @default.
- W3201230890 cites W2167892061 @default.
- W3201230890 cites W2168710876 @default.
- W3201230890 cites W2530193798 @default.
- W3201230890 cites W2884776755 @default.
- W3201230890 cites W2892390723 @default.
- W3201230890 cites W2904112223 @default.
- W3201230890 cites W2911447021 @default.
- W3201230890 cites W2913461521 @default.
- W3201230890 cites W2915169705 @default.
- W3201230890 cites W3018379562 @default.
- W3201230890 cites W3028631687 @default.
- W3201230890 cites W3034516398 @default.
- W3201230890 cites W3047938410 @default.
- W3201230890 cites W3057302762 @default.
- W3201230890 cites W94450069 @default.
- W3201230890 doi "https://doi.org/10.1016/j.alcohol.2021.09.001" @default.
- W3201230890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34530080" @default.
- W3201230890 hasPublicationYear "2021" @default.
- W3201230890 type Work @default.
- W3201230890 sameAs 3201230890 @default.
- W3201230890 citedByCount "7" @default.
- W3201230890 countsByYear W32012308902022 @default.
- W3201230890 countsByYear W32012308902023 @default.
- W3201230890 crossrefType "journal-article" @default.
- W3201230890 hasAuthorship W3201230890A5001894090 @default.
- W3201230890 hasAuthorship W3201230890A5005465511 @default.
- W3201230890 hasAuthorship W3201230890A5012406643 @default.
- W3201230890 hasAuthorship W3201230890A5030321137 @default.
- W3201230890 hasAuthorship W3201230890A5031621157 @default.
- W3201230890 hasAuthorship W3201230890A5043698235 @default.
- W3201230890 hasAuthorship W3201230890A5058824368 @default.