Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201239078> ?p ?o ?g. }
- W3201239078 abstract "Abstract The tumor suppressor protein p53 is situated in the midst of a complex network that is activated in response to cellular stress. An unresolved question is how p53 activates its myriad target genes in response to the severity of the stress signal and consequently coordinates the functional outcome in a timely manner. We have previously shown that DNA torsional flexibility distinguishes among p53 response elements (REs). Here we calculated the flexibility of over 200 p53 REs. By connecting functional pathways of p53-dependent genes to the calculated flexibility of their REs, we show that genes belonging to pathways activated rapidly upon stress (e.g., cell-cycle arrest, energy metabolism and innate immunity) contain REs that are significantly more flexible relative to REs of genes involved in pathways that need to be more strictly regulated or are activated later in the response to stress (e.g., intrinsic apoptosis and p53 negative regulation). The global structural properties of several p53 REs belonging to the different pathways were experimentally validated. Additionally, reporter gene expression driven by flexible p53 REs occurred at lower p53 levels and with faster rates than expression from rigid REs. Moreover, analysis of published endogenous mRNA levels of p53 target genes as a function of the flexibility of their REs support our hypothesis. Overall, we demonstrate that DNA flexibility of p53 REs contributes significantly to the timely expression of p53 target genes and thereby plays an important role in cell-faith decisions in the p53 circuity." @default.
- W3201239078 created "2021-09-27" @default.
- W3201239078 creator A5005464992 @default.
- W3201239078 creator A5011122675 @default.
- W3201239078 creator A5064946822 @default.
- W3201239078 creator A5067747453 @default.
- W3201239078 creator A5069569713 @default.
- W3201239078 creator A5073576943 @default.
- W3201239078 creator A5074196827 @default.
- W3201239078 date "2021-09-19" @default.
- W3201239078 modified "2023-09-27" @default.
- W3201239078 title "Dynamics of p53 DNA binding sites contributes to functional selectivity of p53-driven gene expression" @default.
- W3201239078 cites W1493778881 @default.
- W3201239078 cites W1498410508 @default.
- W3201239078 cites W1562374859 @default.
- W3201239078 cites W1627398520 @default.
- W3201239078 cites W184866859 @default.
- W3201239078 cites W190488077 @default.
- W3201239078 cites W1964719993 @default.
- W3201239078 cites W1971307337 @default.
- W3201239078 cites W1976010548 @default.
- W3201239078 cites W1983822617 @default.
- W3201239078 cites W1985459186 @default.
- W3201239078 cites W1986586522 @default.
- W3201239078 cites W1996899753 @default.
- W3201239078 cites W2003967338 @default.
- W3201239078 cites W2012494636 @default.
- W3201239078 cites W2012711829 @default.
- W3201239078 cites W2019185450 @default.
- W3201239078 cites W2027987224 @default.
- W3201239078 cites W2034614298 @default.
- W3201239078 cites W2041877620 @default.
- W3201239078 cites W2048486410 @default.
- W3201239078 cites W2049220104 @default.
- W3201239078 cites W2064330613 @default.
- W3201239078 cites W2070990294 @default.
- W3201239078 cites W2073175998 @default.
- W3201239078 cites W2073727421 @default.
- W3201239078 cites W2074703985 @default.
- W3201239078 cites W2079328211 @default.
- W3201239078 cites W2080413331 @default.
- W3201239078 cites W2094375196 @default.
- W3201239078 cites W2095994064 @default.
- W3201239078 cites W2100287099 @default.
- W3201239078 cites W2105072114 @default.
- W3201239078 cites W2114308174 @default.
- W3201239078 cites W2116269086 @default.
- W3201239078 cites W2119742986 @default.
- W3201239078 cites W2123016912 @default.
- W3201239078 cites W2129905922 @default.
- W3201239078 cites W2133959309 @default.
- W3201239078 cites W2135963245 @default.
- W3201239078 cites W2137074480 @default.
- W3201239078 cites W2137561800 @default.
- W3201239078 cites W2138000078 @default.
- W3201239078 cites W2152292155 @default.
- W3201239078 cites W2155844132 @default.
- W3201239078 cites W2158266834 @default.
- W3201239078 cites W2166269098 @default.
- W3201239078 cites W2168497623 @default.
- W3201239078 cites W2175728132 @default.
- W3201239078 cites W2341866865 @default.
- W3201239078 cites W2408306345 @default.
- W3201239078 cites W2462696588 @default.
- W3201239078 cites W2735601916 @default.
- W3201239078 cites W2747878742 @default.
- W3201239078 cites W2752942423 @default.
- W3201239078 cites W2754725230 @default.
- W3201239078 cites W2809407169 @default.
- W3201239078 cites W2886286091 @default.
- W3201239078 cites W2920207301 @default.
- W3201239078 cites W2931028025 @default.
- W3201239078 cites W2980921743 @default.
- W3201239078 cites W3010046528 @default.
- W3201239078 cites W3119804401 @default.
- W3201239078 cites W3120613617 @default.
- W3201239078 cites W3123070499 @default.
- W3201239078 cites W3139382390 @default.
- W3201239078 cites W3173694663 @default.
- W3201239078 cites W4200088842 @default.
- W3201239078 doi "https://doi.org/10.1101/2021.09.18.460898" @default.
- W3201239078 hasPublicationYear "2021" @default.
- W3201239078 type Work @default.
- W3201239078 sameAs 3201239078 @default.
- W3201239078 citedByCount "0" @default.
- W3201239078 crossrefType "posted-content" @default.
- W3201239078 hasAuthorship W3201239078A5005464992 @default.
- W3201239078 hasAuthorship W3201239078A5011122675 @default.
- W3201239078 hasAuthorship W3201239078A5064946822 @default.
- W3201239078 hasAuthorship W3201239078A5067747453 @default.
- W3201239078 hasAuthorship W3201239078A5069569713 @default.
- W3201239078 hasAuthorship W3201239078A5073576943 @default.
- W3201239078 hasAuthorship W3201239078A5074196827 @default.
- W3201239078 hasBestOaLocation W32012390781 @default.
- W3201239078 hasConcept C104317684 @default.
- W3201239078 hasConcept C105795698 @default.
- W3201239078 hasConcept C14036430 @default.
- W3201239078 hasConcept C143425029 @default.
- W3201239078 hasConcept C150194340 @default.
- W3201239078 hasConcept C165864922 @default.