FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201250852> ?p ?o ?g. }

• W3201250852 abstract "Abstract Small cell lung cancer (SCLC) is a highly malignant tumor which is eventually refractory to any treatment. Intratumoral heterogeneity (ITH) may contribute to treatment failure. However, the extent of ITH in SCLC is still largely unknown. Here, we subject 120 tumor samples from 40 stage I-III SCLC patients to multi-regional whole-exome sequencing. The most common mutant genes are TP53 (88%) and RB1 (72%). We observe a medium level of mutational heterogeneity (0.30, range 0.0~0.98) and tumor mutational burden (TMB, 10.2 mutations/Mb, range 1.1~51.7). Our SCLC samples also exhibit somatic copy number variation (CNV) across all patients, with an average CNV ITH of 0.49 (range 0.02~0.99). In terms of mutation distribution, ITH, TMB, mutation clusters, and gene signatures, patients with combined SCLC behave roughly the same way as patients with pure SCLC. This condition also exists in smoking patients and patients with EGFR mutations. A higher TMB per cluster is associated with better disease-free survival while single-nucleotide variant ITH is linked to worse overall survival, and therefore these features may be used as prognostic biomarkers for SCLC. Together, these findings demonstrate the intratumoral genetic heterogeneity of surgically resected SCLC and provide insights into resistance to treatment." @default.
• W3201250852 created "2021-09-27" @default.
• W3201250852 creator A5006822602 @default.
• W3201250852 creator A5009420717 @default.
• W3201250852 creator A5013715130 @default.
• W3201250852 creator A5017431309 @default.
• W3201250852 creator A5020252828 @default.
• W3201250852 creator A5023257717 @default.
• W3201250852 creator A5023933133 @default.
• W3201250852 creator A5024732018 @default.
• W3201250852 creator A5025904134 @default.
• W3201250852 creator A5033389000 @default.
• W3201250852 creator A5034785969 @default.
• W3201250852 creator A5037163615 @default.
• W3201250852 creator A5037603466 @default.
• W3201250852 creator A5040265500 @default.
• W3201250852 creator A5046131158 @default.
• W3201250852 creator A5047421180 @default.
• W3201250852 creator A5052712912 @default.
• W3201250852 creator A5057612778 @default.
• W3201250852 creator A5060592435 @default.
• W3201250852 creator A5062604492 @default.
• W3201250852 creator A5064787014 @default.
• W3201250852 creator A5070121957 @default.
• W3201250852 creator A5077605279 @default.
• W3201250852 creator A5081280500 @default.
• W3201250852 creator A5082141776 @default.
• W3201250852 creator A5086065670 @default.
• W3201250852 creator A5090252236 @default.
• W3201250852 creator A5091143438 @default.
• W3201250852 date "2021-09-14" @default.
• W3201250852 modified "2023-10-17" @default.
• W3201250852 title "Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer" @default.
• W3201250852 cites W1903523058 @default.
• W3201250852 cites W1979115864 @default.
• W3201250852 cites W1995472430 @default.
• W3201250852 cites W2056631765 @default.
• W3201250852 cites W2078481614 @default.
• W3201250852 cites W2108927999 @default.
• W3201250852 cites W2117564738 @default.
• W3201250852 cites W2150575159 @default.
• W3201250852 cites W2153586332 @default.
• W3201250852 cites W2154974159 @default.
• W3201250852 cites W2157852151 @default.
• W3201250852 cites W2170490448 @default.
• W3201250852 cites W2180481128 @default.
• W3201250852 cites W2271914738 @default.
• W3201250852 cites W2275877493 @default.
• W3201250852 cites W2276335691 @default.
• W3201250852 cites W2405513305 @default.
• W3201250852 cites W2417483443 @default.
• W3201250852 cites W2551783467 @default.
• W3201250852 cites W2553830626 @default.
• W3201250852 cites W2586629973 @default.
• W3201250852 cites W2605525619 @default.
• W3201250852 cites W2609243345 @default.
• W3201250852 cites W2609687449 @default.
• W3201250852 cites W2745840031 @default.
• W3201250852 cites W2756005140 @default.
• W3201250852 cites W2765782352 @default.
• W3201250852 cites W2783397995 @default.
• W3201250852 cites W2796153225 @default.
• W3201250852 cites W2802690479 @default.
• W3201250852 cites W2893960509 @default.
• W3201250852 cites W2898580681 @default.
• W3201250852 cites W2909296024 @default.
• W3201250852 cites W2951239530 @default.
• W3201250852 cites W2952506496 @default.
• W3201250852 cites W2959872456 @default.
• W3201250852 cites W2966817868 @default.
• W3201250852 cites W2977392388 @default.
• W3201250852 cites W2995889981 @default.
• W3201250852 cites W3000218423 @default.
• W3201250852 cites W3015968101 @default.
• W3201250852 cites W3111170609 @default.
• W3201250852 doi "https://doi.org/10.1038/s41467-021-25787-x" @default.
• W3201250852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8440529" @default.
• W3201250852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34521849" @default.
• W3201250852 hasPublicationYear "2021" @default.
• W3201250852 type Work @default.
• W3201250852 sameAs 3201250852 @default.
• W3201250852 citedByCount "21" @default.
• W3201250852 countsByYear W32012508522021 @default.
• W3201250852 countsByYear W32012508522022 @default.
• W3201250852 countsByYear W32012508522023 @default.
• W3201250852 crossrefType "journal-article" @default.
• W3201250852 hasAuthorship W3201250852A5006822602 @default.
• W3201250852 hasAuthorship W3201250852A5009420717 @default.
• W3201250852 hasAuthorship W3201250852A5013715130 @default.
• W3201250852 hasAuthorship W3201250852A5017431309 @default.
• W3201250852 hasAuthorship W3201250852A5020252828 @default.
• W3201250852 hasAuthorship W3201250852A5023257717 @default.
• W3201250852 hasAuthorship W3201250852A5023933133 @default.
• W3201250852 hasAuthorship W3201250852A5024732018 @default.
• W3201250852 hasAuthorship W3201250852A5025904134 @default.
• W3201250852 hasAuthorship W3201250852A5033389000 @default.
• W3201250852 hasAuthorship W3201250852A5034785969 @default.
• W3201250852 hasAuthorship W3201250852A5037163615 @default.
• W3201250852 hasAuthorship W3201250852A5037603466 @default.
• W3201250852 hasAuthorship W3201250852A5040265500 @default.

• next