Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201258865> ?p ?o ?g. }
- W3201258865 abstract "The hypothesis that prebiotic molecules were transformed into polymers that evolved into proliferating molecular assemblages and eventually a primitive cell was first proposed about 100 years ago. To the best of our knowledge, however, no model of a proliferating prebiotic system has yet been realised because different conditions are required for polymer generation and self-assembly. In this study, we identify conditions suitable for concurrent peptide generation and self-assembly, and we show how a proliferating peptide-based droplet could be created by using synthesised amino acid thioesters as prebiotic monomers. Oligopeptides generated from the monomers spontaneously formed droplets through liquid-liquid phase separation in water. The droplets underwent a steady growth-division cycle by periodic addition of monomers through autocatalytic self-reproduction. Heterogeneous enrichment of RNA and lipids within droplets enabled RNA to protect the droplet from dissolution by lipids. These results provide experimental constructs for origins-of-life research and open up directions in the development of peptide-based materials." @default.
- W3201258865 created "2021-09-27" @default.
- W3201258865 creator A5048600381 @default.
- W3201258865 creator A5053710083 @default.
- W3201258865 date "2021-09-24" @default.
- W3201258865 modified "2023-10-17" @default.
- W3201258865 title "Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life" @default.
- W3201258865 cites W1495374002 @default.
- W3201258865 cites W1520049167 @default.
- W3201258865 cites W1967930768 @default.
- W3201258865 cites W1970147539 @default.
- W3201258865 cites W1970381306 @default.
- W3201258865 cites W1974642361 @default.
- W3201258865 cites W1976192132 @default.
- W3201258865 cites W1979804898 @default.
- W3201258865 cites W1989670168 @default.
- W3201258865 cites W1993575530 @default.
- W3201258865 cites W1999322078 @default.
- W3201258865 cites W2012621789 @default.
- W3201258865 cites W2019367914 @default.
- W3201258865 cites W2021787590 @default.
- W3201258865 cites W2026274581 @default.
- W3201258865 cites W2027522610 @default.
- W3201258865 cites W2031343926 @default.
- W3201258865 cites W2048822729 @default.
- W3201258865 cites W2050110866 @default.
- W3201258865 cites W2054000321 @default.
- W3201258865 cites W2072014193 @default.
- W3201258865 cites W2086400909 @default.
- W3201258865 cites W2090764482 @default.
- W3201258865 cites W2098537197 @default.
- W3201258865 cites W2135893268 @default.
- W3201258865 cites W2140480678 @default.
- W3201258865 cites W2149376555 @default.
- W3201258865 cites W2163548807 @default.
- W3201258865 cites W2171066297 @default.
- W3201258865 cites W2226222217 @default.
- W3201258865 cites W2428808934 @default.
- W3201258865 cites W2490072086 @default.
- W3201258865 cites W2529532508 @default.
- W3201258865 cites W2575949251 @default.
- W3201258865 cites W2603000633 @default.
- W3201258865 cites W2611775510 @default.
- W3201258865 cites W2748771871 @default.
- W3201258865 cites W2753962859 @default.
- W3201258865 cites W2765935674 @default.
- W3201258865 cites W2772280491 @default.
- W3201258865 cites W2803795590 @default.
- W3201258865 cites W2808847099 @default.
- W3201258865 cites W2833923180 @default.
- W3201258865 cites W2903367686 @default.
- W3201258865 cites W2906780606 @default.
- W3201258865 cites W2911306969 @default.
- W3201258865 cites W2919102308 @default.
- W3201258865 cites W2919993307 @default.
- W3201258865 cites W2935978291 @default.
- W3201258865 cites W2943030823 @default.
- W3201258865 cites W2943084464 @default.
- W3201258865 cites W2952674535 @default.
- W3201258865 cites W2962737948 @default.
- W3201258865 cites W3000871795 @default.
- W3201258865 cites W3036724068 @default.
- W3201258865 cites W3042825725 @default.
- W3201258865 cites W3048856379 @default.
- W3201258865 cites W398424092 @default.
- W3201258865 cites W4235033012 @default.
- W3201258865 cites W4237306256 @default.
- W3201258865 cites W654350894 @default.
- W3201258865 doi "https://doi.org/10.1038/s41467-021-25530-6" @default.
- W3201258865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8463549" @default.
- W3201258865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34561428" @default.
- W3201258865 hasPublicationYear "2021" @default.
- W3201258865 type Work @default.
- W3201258865 sameAs 3201258865 @default.
- W3201258865 citedByCount "35" @default.
- W3201258865 countsByYear W32012588652022 @default.
- W3201258865 countsByYear W32012588652023 @default.
- W3201258865 crossrefType "journal-article" @default.
- W3201258865 hasAuthorship W3201258865A5048600381 @default.
- W3201258865 hasAuthorship W3201258865A5053710083 @default.
- W3201258865 hasBestOaLocation W32012588651 @default.
- W3201258865 hasConcept C104317684 @default.
- W3201258865 hasConcept C114032466 @default.
- W3201258865 hasConcept C12554922 @default.
- W3201258865 hasConcept C161790260 @default.
- W3201258865 hasConcept C166940927 @default.
- W3201258865 hasConcept C171250308 @default.
- W3201258865 hasConcept C178790620 @default.
- W3201258865 hasConcept C185592680 @default.
- W3201258865 hasConcept C190161988 @default.
- W3201258865 hasConcept C192562407 @default.
- W3201258865 hasConcept C2775980262 @default.
- W3201258865 hasConcept C2778636629 @default.
- W3201258865 hasConcept C2779281246 @default.
- W3201258865 hasConcept C37263863 @default.
- W3201258865 hasConcept C41625074 @default.
- W3201258865 hasConcept C515207424 @default.
- W3201258865 hasConcept C521977710 @default.
- W3201258865 hasConcept C54355233 @default.
- W3201258865 hasConcept C55493867 @default.