FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201259251> ?p ?o ?g. }

• W3201259251 abstract "Globally, pre‑eclampsia (PE) is a gestational disorder that causes increased morbidity of the fetus and mortality induced by pregnancy. Despite various studies, the understanding of the causes or mechanism of the development of PE remains elusive. Thus, the present study aimed to investigate the role of circular (circ)RNA hsa_circ_0026552 (hsa_circ_0026552) in the development of PE and its mechanism of regulation. hsa_circ_0026552 differential expression in PE tissue data and clinical samples were analyzed and it was observed that hsa_circ_0026552 is highly upregulated in PE samples. Furthermore, miR‑331‑3p was detected as an hsa_circ_0026552 target miRNA and TGF‑βR1 gene as a target of miR‑331‑3p. These results were confirmed using various assays, including dual‑luciferase reporter, reverse transcription‑quantitative PCR and RNA pull‑down assay. It was observed that miR‑331‑3p expression was negatively correlated to hsa_circ_0026552 relative expression, while TGF‑βR1 expression was positively correlated to hsa_circ_0026552 expression evaluated by Pearson's correlation test. The functional experiments, including Cell Counting Kit‑8, colony formation and Transwell assay, showed that silencing hsa_circ_0026552 could significantly strengthen the proliferation, migration and invasion of the trophoblastic HTR‑8/SVneo cells, but the subsequent overexpression of hsa_circ_0026552 reversed this. Mechanistically, it was concluded that hsa_circ_0026552 acts as a miR‑331‑3p sponge to upregulate TGF‑βR1 expression in trophoblasts and is involved significantly in PE development and progression in pregnant women. The circRNA hsa_circ_0026552 could be a novel therapeutic target and prognostic biomarker for PE." @default.
• W3201259251 created "2021-09-27" @default.
• W3201259251 creator A5007292427 @default.
• W3201259251 creator A5030372508 @default.
• W3201259251 date "2021-09-14" @default.
• W3201259251 modified "2023-10-09" @default.
• W3201259251 title "Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the miR‑331‑3p/TGF‑βR1 axis in pre‑eclampsia" @default.
• W3201259251 cites W1866220599 @default.
• W3201259251 cites W1883225649 @default.
• W3201259251 cites W1964847767 @default.
• W3201259251 cites W2035156566 @default.
• W3201259251 cites W2039787319 @default.
• W3201259251 cites W2088939471 @default.
• W3201259251 cites W2192919935 @default.
• W3201259251 cites W2209325576 @default.
• W3201259251 cites W2252831218 @default.
• W3201259251 cites W2284478081 @default.
• W3201259251 cites W2302185643 @default.
• W3201259251 cites W2328311982 @default.
• W3201259251 cites W2329348752 @default.
• W3201259251 cites W2466503257 @default.
• W3201259251 cites W2514258009 @default.
• W3201259251 cites W2550134685 @default.
• W3201259251 cites W2613104259 @default.
• W3201259251 cites W2744347415 @default.
• W3201259251 cites W2762724455 @default.
• W3201259251 cites W2770780206 @default.
• W3201259251 cites W2783500032 @default.
• W3201259251 cites W2790562444 @default.
• W3201259251 cites W2797486805 @default.
• W3201259251 cites W2804131234 @default.
• W3201259251 cites W2805062873 @default.
• W3201259251 cites W2806814376 @default.
• W3201259251 cites W2885269737 @default.
• W3201259251 cites W2888027311 @default.
• W3201259251 cites W2890392090 @default.
• W3201259251 cites W2901182680 @default.
• W3201259251 cites W2902631290 @default.
• W3201259251 cites W2910599425 @default.
• W3201259251 cites W2938935650 @default.
• W3201259251 cites W2944109884 @default.
• W3201259251 cites W2946525881 @default.
• W3201259251 cites W2947766843 @default.
• W3201259251 cites W2949115392 @default.
• W3201259251 cites W2960659672 @default.
• W3201259251 cites W2965482715 @default.
• W3201259251 cites W2966853016 @default.
• W3201259251 cites W2967264555 @default.
• W3201259251 cites W2969359166 @default.
• W3201259251 cites W2982690182 @default.
• W3201259251 cites W2990562098 @default.
• W3201259251 cites W3000617416 @default.
• W3201259251 cites W3004123776 @default.
• W3201259251 cites W3005075361 @default.
• W3201259251 cites W3011765276 @default.
• W3201259251 cites W3037863440 @default.
• W3201259251 cites W3089796023 @default.
• W3201259251 cites W4211203631 @default.
• W3201259251 doi "https://doi.org/10.3892/mmr.2021.12438" @default.
• W3201259251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8456345" @default.
• W3201259251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34523694" @default.
• W3201259251 hasPublicationYear "2021" @default.
• W3201259251 type Work @default.
• W3201259251 sameAs 3201259251 @default.
• W3201259251 citedByCount "7" @default.
• W3201259251 countsByYear W32012592512022 @default.
• W3201259251 countsByYear W32012592512023 @default.
• W3201259251 crossrefType "journal-article" @default.
• W3201259251 hasAuthorship W3201259251A5007292427 @default.
• W3201259251 hasAuthorship W3201259251A5030372508 @default.
• W3201259251 hasBestOaLocation W32012592511 @default.
• W3201259251 hasConcept C104317684 @default.
• W3201259251 hasConcept C119056186 @default.
• W3201259251 hasConcept C127561419 @default.
• W3201259251 hasConcept C145059251 @default.
• W3201259251 hasConcept C1491633281 @default.
• W3201259251 hasConcept C153911025 @default.
• W3201259251 hasConcept C172680121 @default.
• W3201259251 hasConcept C185592680 @default.
• W3201259251 hasConcept C2776953305 @default.
• W3201259251 hasConcept C2777495146 @default.
• W3201259251 hasConcept C2779234561 @default.
• W3201259251 hasConcept C2781018059 @default.
• W3201259251 hasConcept C29537977 @default.
• W3201259251 hasConcept C502942594 @default.
• W3201259251 hasConcept C54355233 @default.
• W3201259251 hasConcept C55493867 @default.
• W3201259251 hasConcept C62112901 @default.
• W3201259251 hasConcept C86803240 @default.
• W3201259251 hasConceptScore W3201259251C104317684 @default.
• W3201259251 hasConceptScore W3201259251C119056186 @default.
• W3201259251 hasConceptScore W3201259251C127561419 @default.
• W3201259251 hasConceptScore W3201259251C145059251 @default.
• W3201259251 hasConceptScore W3201259251C1491633281 @default.
• W3201259251 hasConceptScore W3201259251C153911025 @default.
• W3201259251 hasConceptScore W3201259251C172680121 @default.
• W3201259251 hasConceptScore W3201259251C185592680 @default.
• W3201259251 hasConceptScore W3201259251C2776953305 @default.
• W3201259251 hasConceptScore W3201259251C2777495146 @default.
• W3201259251 hasConceptScore W3201259251C2779234561 @default.

• next