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• W3201274886 abstract "14-3-3s represent a family of highly conserved 30 kDa acidic proteins. 14-3-3s recognize and bind specific phospho-sequences on client partners and operate as molecular hubs to regulate their activity, localization, folding, degradation, and protein-protein interactions. 14-3-3s are also associated with the pathogenesis of several diseases, among which Parkinson's disease (PD). 14-3-3s are found within Lewy bodies (LBs) in PD patients, and their neuroprotective effects have been demonstrated in several animal models of PD. Notably, 14-3-3s interact with some of the major proteins known to be involved in the pathogenesis of PD. Here we first provide a detailed overview of the molecular composition and structural features of 14-3-3s, laying significant emphasis on their peculiar target-binding mechanisms. We then briefly describe the implication of 14-3-3s in the central nervous system and focus on their interaction with LRRK2, α-Synuclein, and Parkin, three of the major players in PD onset and progression. We finally discuss how different types of small molecules may interfere with 14-3-3s interactome, thus representing a valid strategy in the future of drug discovery." @default.
• W3201274886 created "2021-09-27" @default.
• W3201274886 creator A5031000185 @default.
• W3201274886 creator A5042931876 @default.
• W3201274886 creator A5056455938 @default.
• W3201274886 creator A5091739399 @default.
• W3201274886 date "2021-09-21" @default.
• W3201274886 modified "2023-10-17" @default.
• W3201274886 title "Pathways to Parkinson’s disease: a spotlight on 14-3-3 proteins" @default.
• W3201274886 cites W1278338476 @default.
• W3201274886 cites W1493799579 @default.
• W3201274886 cites W1496790952 @default.
• W3201274886 cites W1500409864 @default.
• W3201274886 cites W1502339857 @default.
• W3201274886 cites W1513601545 @default.
• W3201274886 cites W1530609782 @default.
• W3201274886 cites W1549282212 @default.
• W3201274886 cites W1553378240 @default.
• W3201274886 cites W1569287373 @default.
• W3201274886 cites W1790773213 @default.
• W3201274886 cites W1815242288 @default.
• W3201274886 cites W1851334881 @default.
• W3201274886 cites W1876775148 @default.
• W3201274886 cites W1877873625 @default.
• W3201274886 cites W1883429017 @default.
• W3201274886 cites W1937737928 @default.
• W3201274886 cites W1954514489 @default.
• W3201274886 cites W1964941838 @default.
• W3201274886 cites W1965778124 @default.
• W3201274886 cites W1965878499 @default.
• W3201274886 cites W1966281155 @default.
• W3201274886 cites W1967255508 @default.
• W3201274886 cites W1967900265 @default.
• W3201274886 cites W1968031368 @default.
• W3201274886 cites W1970209924 @default.
• W3201274886 cites W1970507353 @default.
• W3201274886 cites W1971180899 @default.
• W3201274886 cites W1972789250 @default.
• W3201274886 cites W1973312670 @default.
• W3201274886 cites W1973338039 @default.
• W3201274886 cites W197448336 @default.
• W3201274886 cites W1975330599 @default.
• W3201274886 cites W1976316003 @default.
• W3201274886 cites W1976345822 @default.
• W3201274886 cites W1976728998 @default.
• W3201274886 cites W1977257516 @default.
• W3201274886 cites W1977391806 @default.
• W3201274886 cites W1977792921 @default.
• W3201274886 cites W1979497016 @default.
• W3201274886 cites W1981605166 @default.
• W3201274886 cites W1982959965 @default.
• W3201274886 cites W1983632956 @default.
• W3201274886 cites W1983945572 @default.
• W3201274886 cites W1984343926 @default.
• W3201274886 cites W1985142623 @default.
• W3201274886 cites W1990283596 @default.
• W3201274886 cites W1990425248 @default.
• W3201274886 cites W1993790203 @default.
• W3201274886 cites W1996607692 @default.
• W3201274886 cites W1997163042 @default.
• W3201274886 cites W1998653769 @default.
• W3201274886 cites W1999953252 @default.
• W3201274886 cites W2000631088 @default.
• W3201274886 cites W2001410943 @default.
• W3201274886 cites W2002370642 @default.
• W3201274886 cites W2002722659 @default.
• W3201274886 cites W2002859616 @default.
• W3201274886 cites W2004536040 @default.
• W3201274886 cites W2006067437 @default.
• W3201274886 cites W2007018052 @default.
• W3201274886 cites W2009826707 @default.
• W3201274886 cites W2010752097 @default.
• W3201274886 cites W2012223636 @default.
• W3201274886 cites W2012399428 @default.
• W3201274886 cites W2013327871 @default.
• W3201274886 cites W2013452582 @default.
• W3201274886 cites W2013828402 @default.
• W3201274886 cites W2014770336 @default.
• W3201274886 cites W2014931132 @default.
• W3201274886 cites W2016269899 @default.
• W3201274886 cites W2016716961 @default.
• W3201274886 cites W2016880575 @default.
• W3201274886 cites W2019933368 @default.
• W3201274886 cites W2020942562 @default.
• W3201274886 cites W2022483806 @default.
• W3201274886 cites W2023040861 @default.
• W3201274886 cites W2024728580 @default.
• W3201274886 cites W2024923170 @default.
• W3201274886 cites W2025007692 @default.
• W3201274886 cites W2027024248 @default.
• W3201274886 cites W2028011991 @default.
• W3201274886 cites W2029252550 @default.
• W3201274886 cites W2029479878 @default.
• W3201274886 cites W2030041656 @default.
• W3201274886 cites W2032817175 @default.
• W3201274886 cites W2034359860 @default.
• W3201274886 cites W2039298117 @default.
• W3201274886 cites W2039369286 @default.
• W3201274886 cites W2046284005 @default.
• W3201274886 cites W2046943799 @default.

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