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- W3201280197 endingPage "112171" @default.
- W3201280197 startingPage "112171" @default.
- W3201280197 abstract "Several studies reported an increase in cardiovascular risk (CVR) in women with polycystic ovary syndrome (PCOS), considered primarily as the result of the combination of all the clinical features that characterize the syndrome, including hyperandrogenism, insulin resistance, diabetes, obesity chronic low-grade inflammation. Interestingly, in 2012 it has been proposed the so-called DOGMA theory, suggesting the pivotal role played by microbiota alteration in the development of PCOS. Subsequently, several authors evidenced the existence in PCOS women of a marked dysbiosis, which is related to the development of metabolic diseases and cardiovascular complications, mainly due to the production of bacteria-derived metabolites that interfere with various pathways. Among these, trimethylamine-N-oxide (TMAO) is emerging as one of the most important and studied microbiota-derived metabolites related to the increase in CVR, due to its pro-atherosclerotic effect. The purpose of the present review is to summarize the evidence in order to support the hypothesis that, in women with PCOS, dysbiosis might be further involved in enhancement of the CVR via contributing to the increase of circulating TMAO. Although no observational studies on a large number of patients directly investigated the serum levels of TMAO in PCOS women, this manuscript aimed to drive future studies in this field, concurring in providing a novel approach for both comprehension and treatment of the CVR in PCOS." @default.
- W3201280197 created "2021-09-27" @default.
- W3201280197 creator A5000060110 @default.
- W3201280197 creator A5040940946 @default.
- W3201280197 creator A5049772805 @default.
- W3201280197 creator A5050040687 @default.
- W3201280197 creator A5065096343 @default.
- W3201280197 creator A5073071586 @default.
- W3201280197 creator A5079494293 @default.
- W3201280197 date "2021-11-01" @default.
- W3201280197 modified "2023-10-14" @default.
- W3201280197 title "Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory" @default.
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