Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201280910> ?p ?o ?g. }
- W3201280910 endingPage "93" @default.
- W3201280910 startingPage "86" @default.
- W3201280910 abstract "Coenzyme Q (CoQ) is vital for energy metabolism in living organisms. In humans, CoQ10 deficiency causes diseases and must be replenished via diet; however, CoQ content in plant foods is primarily low. Here, we report the breeding of high CoQ10 tomato lines by expressing four enzymes with a fruit-specific promoter, which modifies the chloroplast chorismate pathway, enhances cytosolic isoprenoid biosynthesis, and up-regulates the first two reactions in mitochondrion that construct the CoQ10 polyisoprenoid tail. We show that, while the level of the aromatic precursor could be markedly elevated, head group prenylation is the key to increasing the final CoQ10 yield. In the HUCD lines expressing all four transgenes, the highest CoQ10 content (0.15 mg/g dry weight) shows a seven-fold increase from the wild-type level and reaches an extraordinarily rich CoQ10 food grade. Overviewing the changes in other terpenoids by transcriptome and metabolic analyses reveals variable contents of carotenoids and α-tocopherol in the HUCD lines. In addition to the enigmatic relations among different terpenoid pathways, high CoQ10 plants maintaining substantial levels of either vitamin can be selected. Our investigation paves the way for the development of CoQ10-enriched crops as dietary supplements." @default.
- W3201280910 created "2021-09-27" @default.
- W3201280910 creator A5001088057 @default.
- W3201280910 creator A5008089777 @default.
- W3201280910 creator A5018388714 @default.
- W3201280910 creator A5024265672 @default.
- W3201280910 creator A5025615610 @default.
- W3201280910 creator A5025662999 @default.
- W3201280910 creator A5027074931 @default.
- W3201280910 creator A5054487597 @default.
- W3201280910 creator A5056489505 @default.
- W3201280910 creator A5062917884 @default.
- W3201280910 date "2021-11-01" @default.
- W3201280910 modified "2023-10-16" @default.
- W3201280910 title "Engineering high coenzyme Q10 tomato" @default.
- W3201280910 cites W1141855450 @default.
- W3201280910 cites W1521268339 @default.
- W3201280910 cites W1566023545 @default.
- W3201280910 cites W1701273068 @default.
- W3201280910 cites W1958739745 @default.
- W3201280910 cites W1970893992 @default.
- W3201280910 cites W1986396813 @default.
- W3201280910 cites W1995973224 @default.
- W3201280910 cites W2002691581 @default.
- W3201280910 cites W2017926117 @default.
- W3201280910 cites W2022482177 @default.
- W3201280910 cites W2023393277 @default.
- W3201280910 cites W2025794221 @default.
- W3201280910 cites W2044133704 @default.
- W3201280910 cites W2064129745 @default.
- W3201280910 cites W2067178923 @default.
- W3201280910 cites W2090720597 @default.
- W3201280910 cites W2095389529 @default.
- W3201280910 cites W2102639463 @default.
- W3201280910 cites W2111103659 @default.
- W3201280910 cites W2113681544 @default.
- W3201280910 cites W2119479641 @default.
- W3201280910 cites W2123607611 @default.
- W3201280910 cites W2125480666 @default.
- W3201280910 cites W2133348272 @default.
- W3201280910 cites W2161178337 @default.
- W3201280910 cites W2234349414 @default.
- W3201280910 cites W2237501542 @default.
- W3201280910 cites W2593026369 @default.
- W3201280910 cites W2754373993 @default.
- W3201280910 cites W2766584074 @default.
- W3201280910 cites W2797916652 @default.
- W3201280910 cites W2853306818 @default.
- W3201280910 cites W2884433587 @default.
- W3201280910 cites W2980472864 @default.
- W3201280910 cites W2987830461 @default.
- W3201280910 doi "https://doi.org/10.1016/j.ymben.2021.09.007" @default.
- W3201280910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34555495" @default.
- W3201280910 hasPublicationYear "2021" @default.
- W3201280910 type Work @default.
- W3201280910 sameAs 3201280910 @default.
- W3201280910 citedByCount "5" @default.
- W3201280910 countsByYear W32012809102022 @default.
- W3201280910 countsByYear W32012809102023 @default.
- W3201280910 crossrefType "journal-article" @default.
- W3201280910 hasAuthorship W3201280910A5001088057 @default.
- W3201280910 hasAuthorship W3201280910A5008089777 @default.
- W3201280910 hasAuthorship W3201280910A5018388714 @default.
- W3201280910 hasAuthorship W3201280910A5024265672 @default.
- W3201280910 hasAuthorship W3201280910A5025615610 @default.
- W3201280910 hasAuthorship W3201280910A5025662999 @default.
- W3201280910 hasAuthorship W3201280910A5027074931 @default.
- W3201280910 hasAuthorship W3201280910A5054487597 @default.
- W3201280910 hasAuthorship W3201280910A5056489505 @default.
- W3201280910 hasAuthorship W3201280910A5062917884 @default.
- W3201280910 hasBestOaLocation W32012809101 @default.
- W3201280910 hasConcept C104317684 @default.
- W3201280910 hasConcept C134651460 @default.
- W3201280910 hasConcept C181199279 @default.
- W3201280910 hasConcept C183688256 @default.
- W3201280910 hasConcept C206103511 @default.
- W3201280910 hasConcept C2779123261 @default.
- W3201280910 hasConcept C2779384338 @default.
- W3201280910 hasConcept C2780022147 @default.
- W3201280910 hasConcept C28781525 @default.
- W3201280910 hasConcept C553450214 @default.
- W3201280910 hasConcept C55493867 @default.
- W3201280910 hasConcept C6350086 @default.
- W3201280910 hasConcept C69305403 @default.
- W3201280910 hasConcept C86803240 @default.
- W3201280910 hasConceptScore W3201280910C104317684 @default.
- W3201280910 hasConceptScore W3201280910C134651460 @default.
- W3201280910 hasConceptScore W3201280910C181199279 @default.
- W3201280910 hasConceptScore W3201280910C183688256 @default.
- W3201280910 hasConceptScore W3201280910C206103511 @default.
- W3201280910 hasConceptScore W3201280910C2779123261 @default.
- W3201280910 hasConceptScore W3201280910C2779384338 @default.
- W3201280910 hasConceptScore W3201280910C2780022147 @default.
- W3201280910 hasConceptScore W3201280910C28781525 @default.
- W3201280910 hasConceptScore W3201280910C553450214 @default.
- W3201280910 hasConceptScore W3201280910C55493867 @default.
- W3201280910 hasConceptScore W3201280910C6350086 @default.
- W3201280910 hasConceptScore W3201280910C69305403 @default.