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- W3201280934 abstract "The sinonasal microbiota in human upper airway may play an important role in chronic rhinosinusitis (CRS). Thus, this study aimed to investigate the human upper airway microbiome in patients with unilateral CRS, and compare the sinonasal microbiome of the unilateral diseased site with that of a contralateral healthy site. Thirty samples, 15 each from the diseased and healthy sites, were collected from the middle meatus and/or anterior ethmoid region of 15 patients with unilateral CRS during endoscopic sinus surgery. DNA extraction and bacterial microbiome analysis via 16S rRNA gene sequencing were then performed. Corynebacterium showed the highest relative abundance, followed by Staphylococcus in samples from both the diseased and healthy sites. Further, the relative abundances of Staphylococcus and Pseudomonas were significantly lower in samples from diseased sites than in those from healthy sites. Conversely, anaerobes, including Fusobacterium, Bacteroides, and Propionibacterium, were abundantly present in samples from both sites, more so in samples from diseased sites. However, the sites showed no significant difference with respect to richness or diversity (p > 0.05). Our results indicate that CRS might be a polymicrobial infection, and also suggest that Corynebacterium and Staphylococcus may exist as commensals on the sinus mucosal surface in the upper respiratory tract." @default.
- W3201280934 created "2021-09-27" @default.
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- W3201280934 date "2021-09-19" @default.
- W3201280934 modified "2023-10-01" @default.
- W3201280934 title "Microbiome of Unilateral Chronic Rhinosinusitis: A Controlled Paired Analysis" @default.
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- W3201280934 doi "https://doi.org/10.3390/ijerph18189878" @default.
- W3201280934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8469123" @default.
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- W3201280934 hasPublicationYear "2021" @default.
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