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• W3201307589 startingPage "88" @default.
• W3201307589 abstract "• First longitudinal study of cognition in aging marmosets ( Callithrix jacchus) . • Practice effects preceded age-related cognitive decline. • Females exhibited cognitive decline at earlier age than males. • No sex differences in aging for motor abilities, behavior or social stress reactivity. Longitudinal studies are essential to understand healthy and pathological neurocognitive aging such as Alzheimer's Disease, but longitudinal designs are rare in both humans and non-human primate models of aging because of the difficulty of tracking cognitive change in long-lived primates. Common marmosets ( Callithrix jacchus ) are uniquely suited for aging studies due to their naturally short lifespan (10–12 years), sophisticated cognitive and social abilities and Alzheimer Disease-like neuropathology. We report the first longitudinal study of cognitive aging in marmosets (N = 28) as they transitioned from middle- (∼5 years) to old age (∼9 years). We characterized aging trajectories using reversal learning with different stimuli each year. Marmosets initially improved on cognitive performance due to practice, but worsened in the final year, suggesting the onset of age-related decline. Cognitive impairment emerged earlier in females than males and was more prominent for discrimination than for reversal learning. Sex differences in cognitive aging could not be explained by differences in motivation or motor abilities, which improved or remained stable across aging. Likewise, males and females did not differ in aging trajectories of overall behavior or reactivity to a social stressor, with the exception of a progressive decline in the initiation of social behavior in females. Patterns of cognitive aging were highly variable across marmosets of both sexes, suggesting the potential for pathological aging for some individuals. Future work will link individual cognitive trajectories to neuropathology in order to better understand the relationships between neuropathologic burden and vulnerability to age-related cognitive decline in each sex." @default.
• W3201307589 created "2021-09-27" @default.
• W3201307589 creator A5037370723 @default.
• W3201307589 creator A5044083820 @default.
• W3201307589 creator A5046455134 @default.
• W3201307589 creator A5078136532 @default.
• W3201307589 date "2022-01-01" @default.
• W3201307589 modified "2023-10-17" @default.
• W3201307589 title "Sex differences in cognitive aging: a 4-year longitudinal study in marmosets" @default.
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• W3201307589 doi "https://doi.org/10.1016/j.neurobiolaging.2021.09.015" @default.
• W3201307589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34700200" @default.

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