FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201309889> ?p ?o ?g. }

• W3201309889 abstract "m6A RNA methylation regulators can regulate the growth, progression, and invasion of glioma cells by regulating their target genes, which provides a reliable support for the m6A regulator–target axes as the novel therapeutic targets and clinical prognostic signature in glioma. This study aimed to explore the role and prognostic value of m6A RNA methylation regulators and their targets. Expression profiles and clinicopathological data were obtained from the Chinese Glioma Genome Atlas (CGGA), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Clinical Proteome Tumor Analysis Consortium (CPTAC) datasets. Differential expression and correlation analyses were performed between normal and glioma tissues at mRNA and protein levels. Univariate Cox regression, survival, and Lasso Cox regression analyses were conducted to identify and establish the prognostic gene signature. Kaplan–Meier curve, multivariate Cox regression analysis, and ROC were utilized to evaluate the prognostic capacity of the prognostic gene signature. The correlation analysis, systematic bioinformatics analysis, and cell experiment were performed to further understand the potential underlying molecular mechanisms and drug sensitivity. Our results suggested that IGF2BP2, KIAA1429, METTL16, and METTL3, as well as 208 targets are involved in the occurrence of glioma, GBM, and LGG. YTHDF1 and 78 targets involved the occurrence of glioma and GBM, not LGG, among which 181 genes were associated with overall survival. From other findings and our cell experiment results, we demonstrated that METTL3 can activate Notch pathway and facilitate glioma occurrence through regulating its direct targets NOTCH3, DLL3, and HES1, and Notch pathway genes may serve as the potential treatment targets for glioma. Our study established and validated a seven-gene signature comprising METTL3, COL18A1, NASP, PHLPP2, TIMP1, U2AF2, and VEGFA, with a good capability for predicting glioma survival, which may guide therapeutic customization and clinical decision-making. These genes were identified to influence 81 anticancer drug responses, which further contributes to the early phase clinical trials of drug development." @default.
• W3201309889 created "2021-09-27" @default.
• W3201309889 creator A5000532423 @default.
• W3201309889 creator A5007504481 @default.
• W3201309889 creator A5010193269 @default.
• W3201309889 creator A5010444377 @default.
• W3201309889 creator A5013491886 @default.
• W3201309889 creator A5021432821 @default.
• W3201309889 creator A5026205879 @default.
• W3201309889 creator A5037299237 @default.
• W3201309889 creator A5037778807 @default.
• W3201309889 creator A5042976402 @default.
• W3201309889 creator A5046127777 @default.
• W3201309889 creator A5050822501 @default.
• W3201309889 creator A5051156718 @default.
• W3201309889 date "2021-09-13" @default.
• W3201309889 modified "2023-10-01" @default.
• W3201309889 title "Identification of the Role and Clinical Prognostic Value of Target Genes of m6A RNA Methylation Regulators in Glioma" @default.
• W3201309889 cites W1577845700 @default.
• W3201309889 cites W2036044314 @default.
• W3201309889 cites W2040827479 @default.
• W3201309889 cites W2085106808 @default.
• W3201309889 cites W2103196126 @default.
• W3201309889 cites W2115862526 @default.
• W3201309889 cites W2117977572 @default.
• W3201309889 cites W2146512944 @default.
• W3201309889 cites W2169353806 @default.
• W3201309889 cites W2560493566 @default.
• W3201309889 cites W2600862208 @default.
• W3201309889 cites W2750357431 @default.
• W3201309889 cites W2755269699 @default.
• W3201309889 cites W2758836682 @default.
• W3201309889 cites W2761676504 @default.
• W3201309889 cites W2769528818 @default.
• W3201309889 cites W2804658429 @default.
• W3201309889 cites W2885250628 @default.
• W3201309889 cites W2904212208 @default.
• W3201309889 cites W2911411569 @default.
• W3201309889 cites W2922969171 @default.
• W3201309889 cites W2923030053 @default.
• W3201309889 cites W2939559050 @default.
• W3201309889 cites W2946313525 @default.
• W3201309889 cites W2953695321 @default.
• W3201309889 cites W2970534831 @default.
• W3201309889 cites W2972178290 @default.
• W3201309889 cites W2974616751 @default.
• W3201309889 cites W2994295367 @default.
• W3201309889 cites W2994478215 @default.
• W3201309889 cites W3003715948 @default.
• W3201309889 cites W3009078723 @default.
• W3201309889 cites W3010608842 @default.
• W3201309889 cites W3023127603 @default.
• W3201309889 cites W3040759642 @default.
• W3201309889 cites W3087889869 @default.
• W3201309889 cites W3090577314 @default.
• W3201309889 cites W3092369420 @default.
• W3201309889 cites W3118401914 @default.
• W3201309889 cites W3118962566 @default.
• W3201309889 cites W3123218478 @default.
• W3201309889 cites W3128850006 @default.
• W3201309889 cites W3138962944 @default.
• W3201309889 doi "https://doi.org/10.3389/fcell.2021.709022" @default.
• W3201309889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8473691" @default.
• W3201309889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34589481" @default.
• W3201309889 hasPublicationYear "2021" @default.
• W3201309889 type Work @default.
• W3201309889 sameAs 3201309889 @default.
• W3201309889 citedByCount "22" @default.
• W3201309889 countsByYear W32013098892022 @default.
• W3201309889 countsByYear W32013098892023 @default.
• W3201309889 crossrefType "journal-article" @default.
• W3201309889 hasAuthorship W3201309889A5000532423 @default.
• W3201309889 hasAuthorship W3201309889A5007504481 @default.
• W3201309889 hasAuthorship W3201309889A5010193269 @default.
• W3201309889 hasAuthorship W3201309889A5010444377 @default.
• W3201309889 hasAuthorship W3201309889A5013491886 @default.
• W3201309889 hasAuthorship W3201309889A5021432821 @default.
• W3201309889 hasAuthorship W3201309889A5026205879 @default.
• W3201309889 hasAuthorship W3201309889A5037299237 @default.
• W3201309889 hasAuthorship W3201309889A5037778807 @default.
• W3201309889 hasAuthorship W3201309889A5042976402 @default.
• W3201309889 hasAuthorship W3201309889A5046127777 @default.
• W3201309889 hasAuthorship W3201309889A5050822501 @default.
• W3201309889 hasAuthorship W3201309889A5051156718 @default.
• W3201309889 hasBestOaLocation W32013098891 @default.
• W3201309889 hasConcept C104317684 @default.
• W3201309889 hasConcept C150194340 @default.
• W3201309889 hasConcept C161879069 @default.
• W3201309889 hasConcept C190727270 @default.
• W3201309889 hasConcept C2778227246 @default.
• W3201309889 hasConcept C2780283210 @default.
• W3201309889 hasConcept C33288867 @default.
• W3201309889 hasConcept C502942594 @default.
• W3201309889 hasConcept C54355233 @default.
• W3201309889 hasConcept C86803240 @default.
• W3201309889 hasConceptScore W3201309889C104317684 @default.
• W3201309889 hasConceptScore W3201309889C150194340 @default.
• W3201309889 hasConceptScore W3201309889C161879069 @default.
• W3201309889 hasConceptScore W3201309889C190727270 @default.
• W3201309889 hasConceptScore W3201309889C2778227246 @default.

• next