FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201321372> ?p ?o ?g. }

• W3201321372 abstract "Abstract Alzheimer’s disease (AD) affects more than 1 in 9 people age 65 and older and becomes an urgent public health concern as the global population ages. In clinical practice, structural magnetic resonance imaging (sMRI) is the most accessible and widely used diagnostic imaging modality. Additionally, genome-wide association studies (GWAS) and transcriptomics – the study of gene expression – also play an important role in understanding AD etiology and progression. Sophisticated imaging genetics systems have been developed to discover genetic factors that consistently affect brain function and structure. However, most studies to date focused on the relationships between brain sMRI and GWAS or brain sMRI and transcriptomics. To our knowledge, few methods have been developed to discover and infer multimodal relationships among sMRI, GWAS, and transcriptomics. To address this, we propose a novel federated model, Genotype-Expression-Imaging Data Integration (GEIDI), to identify genetic and transcriptomic influences on brain sMRI measures. The relationships between brain imaging measures and gene expression are allowed to depend on a person’s genotype at the single-nucleotide polymorphism (SNP) level, making the inferences adaptive and personalized. We performed extensive experiments on publicly available Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Experimental results demonstrated our proposed method outperformed state-of-the-art expression quantitative trait loci (eQTL) methods for detecting genetic and transcriptomic factors related to AD and has stable performance when data are integrated from multiple sites. Our GEIDI approach may offer novel insights into the relationship among image biomarkers, genotypes, and gene expression and help discover novel genetic targets for potential AD drug treatments." @default.
• W3201321372 created "2021-09-27" @default.
• W3201321372 creator A5003523497 @default.
• W3201321372 creator A5016131945 @default.
• W3201321372 creator A5051082404 @default.
• W3201321372 creator A5062600928 @default.
• W3201321372 creator A5069168079 @default.
• W3201321372 creator A5074086871 @default.
• W3201321372 creator A5080585531 @default.
• W3201321372 date "2021-09-16" @default.
• W3201321372 modified "2023-10-16" @default.
• W3201321372 title "Integrating Transcriptomics, Genomics, and Imaging in Alzheimer’s Disease: A Federated Model" @default.
• W3201321372 cites W1901948746 @default.
• W3201321372 cites W1983721404 @default.
• W3201321372 cites W1984536024 @default.
• W3201321372 cites W1984760904 @default.
• W3201321372 cites W1993616000 @default.
• W3201321372 cites W2024363942 @default.
• W3201321372 cites W2039627167 @default.
• W3201321372 cites W2040912377 @default.
• W3201321372 cites W2069089843 @default.
• W3201321372 cites W2086632167 @default.
• W3201321372 cites W2100697281 @default.
• W3201321372 cites W2110496823 @default.
• W3201321372 cites W2112957305 @default.
• W3201321372 cites W2113319997 @default.
• W3201321372 cites W2115779804 @default.
• W3201321372 cites W2121957784 @default.
• W3201321372 cites W2124999415 @default.
• W3201321372 cites W2140054173 @default.
• W3201321372 cites W2142367912 @default.
• W3201321372 cites W2144570481 @default.
• W3201321372 cites W2146249493 @default.
• W3201321372 cites W2161633633 @default.
• W3201321372 cites W2226495311 @default.
• W3201321372 cites W2460724252 @default.
• W3201321372 cites W2504196632 @default.
• W3201321372 cites W2591226121 @default.
• W3201321372 cites W2605310688 @default.
• W3201321372 cites W2610795807 @default.
• W3201321372 cites W2614622258 @default.
• W3201321372 cites W2619410643 @default.
• W3201321372 cites W2735421894 @default.
• W3201321372 cites W2743859995 @default.
• W3201321372 cites W2755506013 @default.
• W3201321372 cites W2755897284 @default.
• W3201321372 cites W2758994358 @default.
• W3201321372 cites W2791285756 @default.
• W3201321372 cites W2795944109 @default.
• W3201321372 cites W2802923338 @default.
• W3201321372 cites W2803944211 @default.
• W3201321372 cites W2805677676 @default.
• W3201321372 cites W2811129245 @default.
• W3201321372 cites W2895486342 @default.
• W3201321372 cites W2895889273 @default.
• W3201321372 cites W2915118821 @default.
• W3201321372 cites W2919242678 @default.
• W3201321372 cites W2947761451 @default.
• W3201321372 cites W2950047891 @default.
• W3201321372 cites W2950796920 @default.
• W3201321372 cites W2982638646 @default.
• W3201321372 cites W2992456978 @default.
• W3201321372 cites W3004604554 @default.
• W3201321372 cites W3009441391 @default.
• W3201321372 cites W3045674654 @default.
• W3201321372 cites W3093983570 @default.
• W3201321372 cites W3099081599 @default.
• W3201321372 cites W3100885348 @default.
• W3201321372 cites W3104418050 @default.
• W3201321372 cites W3173024175 @default.
• W3201321372 cites W3194050383 @default.
• W3201321372 cites W4234698323 @default.
• W3201321372 cites W4236653706 @default.
• W3201321372 doi "https://doi.org/10.1101/2021.09.14.460367" @default.
• W3201321372 hasPublicationYear "2021" @default.
• W3201321372 type Work @default.
• W3201321372 sameAs 3201321372 @default.
• W3201321372 citedByCount "0" @default.
• W3201321372 crossrefType "posted-content" @default.
• W3201321372 hasAuthorship W3201321372A5003523497 @default.
• W3201321372 hasAuthorship W3201321372A5016131945 @default.
• W3201321372 hasAuthorship W3201321372A5051082404 @default.
• W3201321372 hasAuthorship W3201321372A5062600928 @default.
• W3201321372 hasAuthorship W3201321372A5069168079 @default.
• W3201321372 hasAuthorship W3201321372A5074086871 @default.
• W3201321372 hasAuthorship W3201321372A5080585531 @default.
• W3201321372 hasBestOaLocation W32013213721 @default.
• W3201321372 hasConcept C104317684 @default.
• W3201321372 hasConcept C106208931 @default.
• W3201321372 hasConcept C135763542 @default.
• W3201321372 hasConcept C141231307 @default.
• W3201321372 hasConcept C142724271 @default.
• W3201321372 hasConcept C150194340 @default.
• W3201321372 hasConcept C153209595 @default.
• W3201321372 hasConcept C162317418 @default.
• W3201321372 hasConcept C168393362 @default.
• W3201321372 hasConcept C169760540 @default.
• W3201321372 hasConcept C18183760 @default.
• W3201321372 hasConcept C186413461 @default.
• W3201321372 hasConcept C189206191 @default.

• next