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- W3201325144 endingPage "2484" @default.
- W3201325144 startingPage "2484" @default.
- W3201325144 abstract "With the nucleus as an exception, mitochondria are the only animal cell organelles containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte maturation, the mtDNA copy number dramatically increases and the distribution of mitochondria changes significantly. As oocyte maturation requires a large amount of ATP for continuous transcription and translation, the availability of the right number of functional mitochondria is crucial. There is a correlation between the quality of oocytes and both the amount of mtDNA and the amount of ATP. Suboptimal conditions of in vitro maturation (IVM) might lead to changes in the mitochondrial morphology as well as alternations in the expression of genes encoding proteins associated with mitochondrial function. Dysfunctional mitochondria have a lower ability to counteract reactive oxygen species (ROS) production which leads to oxidative stress. The mitochondrial function might be improved with the application of antioxidants and significant expectations are laid on the development of new IVM systems supplemented with mitochondria-targeted reagents. Different types of antioxidants have been tested already on animal models and human rescue IVM oocytes, showing promising results. This review focuses on the recent observations on oocytes' intracellular mitochondrial distribution and on mitochondrial genomes during their maturation, both in vivo and in vitro. Recent mitochondrial supplementation studies, aiming to improve oocyte developmental potential, are summarized." @default.
- W3201325144 created "2021-09-27" @default.
- W3201325144 creator A5020074944 @default.
- W3201325144 creator A5032613678 @default.
- W3201325144 creator A5038319290 @default.
- W3201325144 creator A5050882241 @default.
- W3201325144 date "2021-09-19" @default.
- W3201325144 modified "2023-10-18" @default.
- W3201325144 title "The Role of Mitochondria in Oocyte Maturation" @default.
- W3201325144 cites W1107208185 @default.
- W3201325144 cites W1512824421 @default.
- W3201325144 cites W1527674703 @default.
- W3201325144 cites W1966044281 @default.
- W3201325144 cites W1970857726 @default.
- W3201325144 cites W1979389283 @default.
- W3201325144 cites W1987710045 @default.
- W3201325144 cites W1988876420 @default.
- W3201325144 cites W1990527421 @default.
- W3201325144 cites W1994640446 @default.
- W3201325144 cites W1996943057 @default.
- W3201325144 cites W1999223830 @default.
- W3201325144 cites W2000454435 @default.
- W3201325144 cites W2011116207 @default.
- W3201325144 cites W2012025495 @default.
- W3201325144 cites W2013588487 @default.
- W3201325144 cites W2015638974 @default.
- W3201325144 cites W2016179972 @default.
- W3201325144 cites W2016511912 @default.
- W3201325144 cites W2017692041 @default.
- W3201325144 cites W2020947215 @default.
- W3201325144 cites W2025779835 @default.
- W3201325144 cites W2025860531 @default.
- W3201325144 cites W2031054302 @default.
- W3201325144 cites W2031066055 @default.
- W3201325144 cites W2033275867 @default.
- W3201325144 cites W2037150857 @default.
- W3201325144 cites W2040151712 @default.
- W3201325144 cites W2044980068 @default.
- W3201325144 cites W2047199934 @default.
- W3201325144 cites W2047773874 @default.
- W3201325144 cites W2049385146 @default.
- W3201325144 cites W2053329186 @default.
- W3201325144 cites W2053829558 @default.
- W3201325144 cites W2053901293 @default.
- W3201325144 cites W2056425757 @default.
- W3201325144 cites W2057695252 @default.
- W3201325144 cites W2072902622 @default.
- W3201325144 cites W2078575160 @default.
- W3201325144 cites W2081459419 @default.
- W3201325144 cites W2084621494 @default.
- W3201325144 cites W2089469535 @default.
- W3201325144 cites W2091296592 @default.
- W3201325144 cites W2093006609 @default.
- W3201325144 cites W2097186411 @default.
- W3201325144 cites W2097395681 @default.
- W3201325144 cites W2101833075 @default.
- W3201325144 cites W2103443165 @default.
- W3201325144 cites W2108230430 @default.
- W3201325144 cites W2109291482 @default.
- W3201325144 cites W2112157313 @default.
- W3201325144 cites W2113729748 @default.
- W3201325144 cites W2115021528 @default.
- W3201325144 cites W2115359101 @default.
- W3201325144 cites W2126868334 @default.
- W3201325144 cites W2143558309 @default.
- W3201325144 cites W2144458575 @default.
- W3201325144 cites W2144534399 @default.
- W3201325144 cites W2144600435 @default.
- W3201325144 cites W2151877403 @default.
- W3201325144 cites W2158662747 @default.
- W3201325144 cites W2165971246 @default.
- W3201325144 cites W2168754435 @default.
- W3201325144 cites W2197191620 @default.
- W3201325144 cites W2317744299 @default.
- W3201325144 cites W2329563304 @default.
- W3201325144 cites W2344732231 @default.
- W3201325144 cites W2614953275 @default.
- W3201325144 cites W2622160583 @default.
- W3201325144 cites W2624100714 @default.
- W3201325144 cites W2751304555 @default.
- W3201325144 cites W2754935915 @default.
- W3201325144 cites W2765119927 @default.
- W3201325144 cites W2774274736 @default.
- W3201325144 cites W2790446406 @default.
- W3201325144 cites W2800720120 @default.
- W3201325144 cites W2803306064 @default.
- W3201325144 cites W2803581370 @default.
- W3201325144 cites W2809281987 @default.
- W3201325144 cites W2890791114 @default.
- W3201325144 cites W2898534233 @default.
- W3201325144 cites W2912244588 @default.
- W3201325144 cites W2936995431 @default.
- W3201325144 cites W2944787598 @default.
- W3201325144 cites W2966718372 @default.
- W3201325144 cites W2968944381 @default.
- W3201325144 cites W2971100474 @default.
- W3201325144 cites W2972093186 @default.
- W3201325144 cites W2980622391 @default.