FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201327672> ?p ?o ?g. }

• W3201327672 endingPage "131511" @default.
• W3201327672 startingPage "131511" @default.
• W3201327672 abstract "We explored the anticancer activity of two synthetic flavonoid-based small molecules, HMDC and HMDF, with bioactive methylenedioxy functionality. HMDF inhibited the proliferation of the p53 wild-type (NCIH460 and A549), and p53 null (NCIH1299) non-small cell lung cancer and breast cancer (MCF-7) cells more potently than HMDC without significant cytotoxic effects on the normal lung-epithelial (L132) and macrophage (Raw 264.7) cells. HMDF mediated reduction of the cell proliferation occurred due to its attachment at the p53-binding domain of MDM2 (also evident from molecular docking analysis), which induced the disruption of the p53-MDM2 interactions. Ultimately, a higher expression of p53 in the NCIH460 cells was observed. The up-regulated p53 level instigated apoptosis of cancer cells. However, MDM2 expression level remained unaltered. The docking studies further indicate that HMDF can suppress the anti-apoptotic activity of Bcl-2 protein by blocking its BH3 domain." @default.
• W3201327672 created "2021-09-27" @default.
• W3201327672 creator A5014111355 @default.
• W3201327672 creator A5016534607 @default.
• W3201327672 creator A5021781105 @default.
• W3201327672 creator A5028636616 @default.
• W3201327672 creator A5053844408 @default.
• W3201327672 creator A5063065993 @default.
• W3201327672 creator A5081378779 @default.
• W3201327672 date "2022-01-01" @default.
• W3201327672 modified "2023-09-23" @default.
• W3201327672 title "Understanding the Role of Flavonoid Based Small Molecules in Modulating the Oncogenic Protein-Protein Interactions: A Quest for Therapeutic Arsenal" @default.
• W3201327672 cites W1567485746 @default.
• W3201327672 cites W1775749144 @default.
• W3201327672 cites W1967671116 @default.
• W3201327672 cites W1969350101 @default.
• W3201327672 cites W1970651334 @default.
• W3201327672 cites W1976261939 @default.
• W3201327672 cites W1991494214 @default.
• W3201327672 cites W1992006348 @default.
• W3201327672 cites W1993591356 @default.
• W3201327672 cites W1996884434 @default.
• W3201327672 cites W2000428769 @default.
• W3201327672 cites W2002272542 @default.
• W3201327672 cites W2003768436 @default.
• W3201327672 cites W2008887283 @default.
• W3201327672 cites W2019060471 @default.
• W3201327672 cites W2023486531 @default.
• W3201327672 cites W2026513042 @default.
• W3201327672 cites W2026873328 @default.
• W3201327672 cites W2052966836 @default.
• W3201327672 cites W2062612693 @default.
• W3201327672 cites W2066749591 @default.
• W3201327672 cites W2067305633 @default.
• W3201327672 cites W2071876908 @default.
• W3201327672 cites W2078166953 @default.
• W3201327672 cites W2084156461 @default.
• W3201327672 cites W2097933346 @default.
• W3201327672 cites W2099907467 @default.
• W3201327672 cites W2129896434 @default.
• W3201327672 cites W2145501898 @default.
• W3201327672 cites W2146346788 @default.
• W3201327672 cites W2158534713 @default.
• W3201327672 cites W2217340753 @default.
• W3201327672 cites W2261140985 @default.
• W3201327672 cites W2346382518 @default.
• W3201327672 cites W2605308265 @default.
• W3201327672 cites W2742755811 @default.
• W3201327672 cites W2748053146 @default.
• W3201327672 cites W2760412909 @default.
• W3201327672 cites W2886975788 @default.
• W3201327672 cites W2923099100 @default.
• W3201327672 cites W3005533031 @default.
• W3201327672 doi "https://doi.org/10.1016/j.molstruc.2021.131511" @default.
• W3201327672 hasPublicationYear "2022" @default.
• W3201327672 type Work @default.
• W3201327672 sameAs 3201327672 @default.
• W3201327672 citedByCount "0" @default.
• W3201327672 crossrefType "journal-article" @default.
• W3201327672 hasAuthorship W3201327672A5014111355 @default.
• W3201327672 hasAuthorship W3201327672A5016534607 @default.
• W3201327672 hasAuthorship W3201327672A5021781105 @default.
• W3201327672 hasAuthorship W3201327672A5028636616 @default.
• W3201327672 hasAuthorship W3201327672A5053844408 @default.
• W3201327672 hasAuthorship W3201327672A5063065993 @default.
• W3201327672 hasAuthorship W3201327672A5081378779 @default.
• W3201327672 hasConcept C109316439 @default.
• W3201327672 hasConcept C121608353 @default.
• W3201327672 hasConcept C154317977 @default.
• W3201327672 hasConcept C159110408 @default.
• W3201327672 hasConcept C185592680 @default.
• W3201327672 hasConcept C190283241 @default.
• W3201327672 hasConcept C202751555 @default.
• W3201327672 hasConcept C2776192174 @default.
• W3201327672 hasConcept C2778004101 @default.
• W3201327672 hasConcept C2779054382 @default.
• W3201327672 hasConcept C41685203 @default.
• W3201327672 hasConcept C502942594 @default.
• W3201327672 hasConcept C54355233 @default.
• W3201327672 hasConcept C55493867 @default.
• W3201327672 hasConcept C62112901 @default.
• W3201327672 hasConcept C71924100 @default.
• W3201327672 hasConcept C81729549 @default.
• W3201327672 hasConcept C86803240 @default.
• W3201327672 hasConcept C95444343 @default.
• W3201327672 hasConcept C96232424 @default.
• W3201327672 hasConceptScore W3201327672C109316439 @default.
• W3201327672 hasConceptScore W3201327672C121608353 @default.
• W3201327672 hasConceptScore W3201327672C154317977 @default.
• W3201327672 hasConceptScore W3201327672C159110408 @default.
• W3201327672 hasConceptScore W3201327672C185592680 @default.
• W3201327672 hasConceptScore W3201327672C190283241 @default.
• W3201327672 hasConceptScore W3201327672C202751555 @default.
• W3201327672 hasConceptScore W3201327672C2776192174 @default.
• W3201327672 hasConceptScore W3201327672C2778004101 @default.
• W3201327672 hasConceptScore W3201327672C2779054382 @default.
• W3201327672 hasConceptScore W3201327672C41685203 @default.
• W3201327672 hasConceptScore W3201327672C502942594 @default.

• next